GenomeNet

Database: UniProt
Entry: B4L1K2
LinkDB: B4L1K2
Original site: B4L1K2 
ID   UBA5_DROMO              Reviewed;         399 AA.
AC   B4L1K2;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   16-JAN-2019, entry version 50.
DE   RecName: Full=Ubiquitin-like modifier-activating enzyme 5;
DE            Short=Ubiquitin-activating enzyme 5;
GN   ORFNames=GI14749;
OS   Drosophila mojavensis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15081-1352.22;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: E1-like enzyme which activates UFM1. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family. UBA5
CC       subfamily. {ECO:0000305}.
DR   EMBL; CH933810; EDW07638.1; -; Genomic_DNA.
DR   RefSeq; XP_002010321.1; XM_002010285.2.
DR   SMR; B4L1K2; -.
DR   PRIDE; B4L1K2; -.
DR   EnsemblMetazoa; FBtr0165474; FBpp0163966; FBgn0137500.
DR   GeneID; 6584677; -.
DR   KEGG; dmo:Dmoj_GI14749; -.
DR   FlyBase; FBgn0137500; Dmoj\GI14749.
DR   InParanoid; B4L1K2; -.
DR   KO; K12164; -.
DR   OMA; ETHNYNI; -.
DR   OrthoDB; 1092362at2759; -.
DR   PhylomeDB; B4L1K2; -.
DR   Proteomes; UP000009192; Unassembled WGS sequence.
DR   Bgee; FBgn0137500; Expressed in 2 organ(s), highest expression level in adult organism.
DR   GO; GO:0019008; C:molybdopterin synthase complex; IEA:EnsemblMetazoa.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR   GO; GO:0050905; P:neuromuscular process; IEA:EnsemblMetazoa.
DR   InterPro; IPR029752; D-isomer_DH_CS1.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   Pfam; PF00899; ThiF; 1.
DR   SUPFAM; SSF69572; SSF69572; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding;
KW   Reference proteome; Ubl conjugation pathway; Zinc.
FT   CHAIN         1    399       Ubiquitin-like modifier-activating enzyme
FT                                5.
FT                                /FTId=PRO_0000391945.
FT   ACT_SITE    243    243       Glycyl thioester intermediate.
FT                                {ECO:0000250}.
FT   METAL       219    219       Zinc. {ECO:0000250}.
FT   METAL       222    222       Zinc. {ECO:0000250}.
FT   METAL       296    296       Zinc. {ECO:0000250}.
FT   METAL       301    301       Zinc. {ECO:0000250}.
FT   BINDING      76     76       ATP; via amide nitrogen. {ECO:0000250}.
FT   BINDING      97     97       ATP. {ECO:0000250}.
FT   BINDING     120    120       ATP. {ECO:0000250}.
FT   BINDING     143    143       ATP. {ECO:0000250}.
FT   BINDING     177    177       ATP. {ECO:0000250}.
SQ   SEQUENCE   399 AA;  44006 MW;  7338F52518526000 CRC64;
     MSTAIDELQA IIAELKTELE EQKTSTRIAR ERIERMSAEV VDSNPYSRLM ALQRMNIVKD
     YERIRDKAVA IVGVGGVGSV TADMLTRCGI GKLILFDYDK VELANMNRLF FTPDQAGLSK
     VEAAARTLSF INPDVVIETH NYNITTVENF DKFLTTISES GLQKGQPVDL VLSCVDNFEA
     RMAINAACNE NNLNWFESGV SENAVSGHIQ FIRPGETACF ACAPPLVVAE NIDERTLKRE
     GVCAASLPTT MGITAGLLVQ NALKYLLNFG EVSDYLGYNA LNDFFPKMTL KPNAECDDRY
     CLQRQKEFQA RPQPKEQQID EVVSNEPLHA SNDWGIELVA EDAPVEQQTT NTTNVASGLR
     LAYEAPDKVD VNQSESAAVV NAGLPETSLD DLMAQMKSM
//
DBGET integrated database retrieval system