ID B4LGJ1_DROVI Unreviewed; 1229 AA.
AC B4LGJ1;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 78.
DE RecName: Full=Splicing factor 3B subunit 3 {ECO:0000256|ARBA:ARBA00040929};
GN Name=Dvir\GJ13230 {ECO:0000313|EMBL:EDW69429.1};
GN ORFNames=Dvir_GJ13230 {ECO:0000313|EMBL:EDW69429.1};
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244 {ECO:0000313|EMBL:EDW69429.1, ECO:0000313|Proteomes:UP000008792};
RN [1] {ECO:0000313|EMBL:EDW69429.1, ECO:0000313|Proteomes:UP000008792}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RSE1 family.
CC {ECO:0000256|ARBA:ARBA00038266}.
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DR EMBL; CH940647; EDW69429.1; -; Genomic_DNA.
DR RefSeq; XP_002047087.1; XM_002047051.2.
DR AlphaFoldDB; B4LGJ1; -.
DR SMR; B4LGJ1; -.
DR STRING; 7244.B4LGJ1; -.
DR EnsemblMetazoa; FBtr0229155; FBpp0227647; FBgn0200456.
DR GeneID; 6622999; -.
DR KEGG; dvi:6622999; -.
DR eggNOG; KOG1898; Eukaryota.
DR HOGENOM; CLU_003246_0_0_1; -.
DR InParanoid; B4LGJ1; -.
DR OMA; PRATGHW; -.
DR OrthoDB; 101343at2759; -.
DR PhylomeDB; B4LGJ1; -.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0000124; C:SAGA complex; IEA:EnsemblMetazoa.
DR GO; GO:0005686; C:U2 snRNP; IEA:EnsemblMetazoa.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR004871; Cleavage/polyA-sp_fac_asu_C.
DR InterPro; IPR018846; Cleavage/polyA-sp_fac_asu_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR10644; DNA REPAIR/RNA PROCESSING CPSF FAMILY; 1.
DR PANTHER; PTHR10644:SF1; SPLICING FACTOR 3B SUBUNIT 3; 1.
DR Pfam; PF03178; CPSF_A; 1.
DR Pfam; PF10433; MMS1_N; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008792}.
FT DOMAIN 76..592
FT /note="Cleavage/polyadenylation specificity factor A
FT subunit N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10433"
FT DOMAIN 874..1195
FT /note="Cleavage/polyadenylation specificity factor A
FT subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03178"
SQ SEQUENCE 1229 AA; 136680 MW; 48816F2B23B37FD9 CRC64;
MYLYNLTLQK GTGVTHAVHG NFSGGKQQEV LLSRGKSLEL LRPDPNTGKV HTLMSTEIFG
CIRALMAFRL TGGTKDYIVV GSDSGRIVIL EYIPSKNSLE KVHQETFGKS GCRRIVPGQY
FAIDPKGRAV MIGAVEKQKL AYIMNRDTQA RLTISSPLEA HKSNTLTYHM VGVDVGFDNP
MFACLEIDYE EADLDPSGDA AQRTQQTLTF YELDLGLNHV VRKYSEPLEE HANFLVSVPG
GNDGPSGVLI CSENYLTYKN LGDQHDIRCP IPRRRNDLDD PERGMIFICS ATHRTKSMYF
FLLQTEQGDI FKITLETDDD VVSEIKLKYF DTVPPATAMC VLKTGFLFVA SEFGNHYLYQ
IAHLGDDDDE PEFSSAMPLE EGETFFFAPR ALKNLVLVDE LPSFAPIITS QVADLANEDT
PQLYVLCGRG PRSTLRVLRH GLEVSEMAVS ELPGNPNAVW TVKKRIDDEF DAYIIVSFVN
ATLVLSIGET VEEVTDSGFL GTTPTLCCAA LGDDALVQVY PDGIRHIRSD KRVNEWKAPG
KKSITKCAVN QRQVVITLSG RELVYFEMDP TGELNEYTER SEMPAEIMCM ALGTVPEGEQ
RSWFLAVGLA DNTVRILSLD PNNCLSPCSM QALPSPAESL CLVEMGHTES TTNAGGADDD
VPAQRSGGSN KGTIYLNIGL SNGVLLRTVL DPVSGDLADT RTRYLGSRPV KLFRIKMQGA
EAVLAMSSRT WLSYYHQNRF HLTPLSYETL EYASGFSSEQ CSEGIVAIST NTLRILALEK
LGAVFNQVAF PLQFTPRAFV IHPDTGRMLI AETDHNAYTE DTKNTRKEQM AEEMRSAAGD
EERELAREMA NAFINEVLPE DVFSAPKAGL GLWASQIRCL DAMHGQTMFS VPLTQNEAIM
SMTLLKFSVA ADGRYYLAVG IAKDLQLNPR ISQGGCIDIY KIDPTCSALE FLHRTEIDEI
PGALCGFQGR LLAGCGRMLR IYDLGKKKML RKCENKHIPY QIVNIQAMGH RVYVSDVQES
VFFIRYRRAE NQLIIFADDT HPRWVTATTL LDYDTIAIAD KFGNLSIQRL PHSVTDDVDE
DPTGTKSLWD RGLLSGASQK SENICSFHVG EIIMSLQKAT LIPGGSEALI YATLSGTVGA
FVPFTSREDY DFFQHLEMHM RNENPPLCGR DHLSYRSSYY PVKNVLDGDL CEQYLSIDAV
KQKSIAGDMF RTPNQICKKL EDIRTRYAF
//
