ID B4LMZ8_DROVI Unreviewed; 1422 AA.
AC B4LMZ8;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Apple domain-containing protein {ECO:0000259|PROSITE:PS50948};
GN Name=Dvir\GJ19935 {ECO:0000313|EMBL:EDW62113.2};
GN ORFNames=Dvir_GJ19935 {ECO:0000313|EMBL:EDW62113.2};
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244 {ECO:0000313|EMBL:EDW62113.2, ECO:0000313|Proteomes:UP000008792};
RN [1] {ECO:0000313|EMBL:EDW62113.2, ECO:0000313|Proteomes:UP000008792}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
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DR EMBL; CH940648; EDW62113.2; -; Genomic_DNA.
DR RefSeq; XP_002050920.2; XM_002050884.2.
DR STRING; 7244.B4LMZ8; -.
DR EnsemblMetazoa; FBtr0442994; FBpp0399430; FBgn0207077.
DR eggNOG; ENOG502QTPZ; Eukaryota.
DR HOGENOM; CLU_005875_0_0_1; -.
DR InParanoid; B4LMZ8; -.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0019953; P:sexual reproduction; IEA:EnsemblMetazoa.
DR CDD; cd01099; PAN_AP_HGF; 3.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 3.
DR InterPro; IPR003609; Pan_app.
DR PANTHER; PTHR47327:SF13; APPLE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47327; FI18240P1-RELATED; 1.
DR SMART; SM00473; PAN_AP; 3.
DR SUPFAM; SSF57414; Hairpin loop containing domain-like; 2.
DR PROSITE; PS50948; PAN; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008792}.
FT DOMAIN 82..174
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 487..579
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 920..1004
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 1034..1121
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT REGION 281..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 601..827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 874..895
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1009..1028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1338..1382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..420
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..617
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..654
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..714
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..745
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 764..790
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1338..1353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1360..1381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1422 AA; 159580 MW; CC18627F4506DC06 CRC64;
MSSVEIRRIL AAAGAAAPAA GHARLTLPAA QLSRLKSRCR GADEEQPRPE LDDVSEHDKL
LLANLAAALT VDNQLVSARN DCFERIALEA MLPFEKTFRT EDTNSLKMCK EKCLQAGEKC
QAISFGVHRR GNGTCQLSSE QYGGGGGGGG GSSGRPGGVI FDPDFDLYAR KTNCFDLSDN
SIGAPSPIST GVTPVNLPNR PLDVGNTPVL VVNPTPHTNQ PEAPQPVPTP PGVGDRLYFS
HEIYPLYKYP TLYEHNYPAP NEEVYIPGGY AANVPEVDER YRPSYGPLDE ESIRPTPHGP
PRPIFGLGYG NGYSYGTPER YAPTTLRPAS GERPSYAPRP DYGSERPDYP QPSPARPFDS
STSPGYGPRP TSTYDGPGEP RPDYTNRPDP PPHTAHDSGY GPGPGSSARP PPYDRPPSPL
PPRDEYMRRN GSAMRPDGYY DDDKTIATYF NPEDYVHGNK KPPMPMPMPM PGDRDRDRYP
MDEMNACFRR VLAGKRIAPH WVRRSISCER VEDCMRECGH EKRFMCEGFN YRLDPSGHGQ
GDCELIELPL SQMDLYSSAN RRDSNMLRHP DYDYYERDRN APSSCRRSAC QDCSKGPISS
NPIYFKPSSS GGGSYPPGPS SSGGGGGYGG DRERDRDRER DRDRDRDRDH YRPPPPHSST
AVDHYRGPSG PSSSSYEHRP FSTDYHSSHS SSSASSSYEF SSHGSGTGSG YFGHTPPSSF
GDHSRPDYID RHDYARPEPP SRYRPDRWET LPSSSGYDSS AYRPPRPETD RIDKYRPSYR
PGHDYSPYRP HEPSRPAPAG PPATGLAHNY LDRDGPGSGP GPASVSYKKP SKFVPYLIGA
EEQLGNYGGG NSKHSFYESQ RRKDQHDFNY FELGSTHHRE PPRESNAVLR YPGSSYDQDY
PRLRNDYRQQ WTRRPGPDEC SAKTSEGFRL HKTAVKHAFN VPTLTECERL CSDQRPSFIC
HTFSYRYNQA GRDNCMLCDR PVNMLDYYVD IEPDRDYDIY SMADDMDVCR SPSPPPRRSD
GPSTALSDPR NAQCFFRAID ATRFFKSIVR DSLTVRSVGE CEMECIRSTK FTCRAFAFRY
GQQRHAGVID NCQLSDWPVR DMDKERHLIL DAAFDIFERA SYGHGCEIQP IMDEKHKKLC
YLGYGSPARL LPPAIKKVIS VPSEMACKKE CIRFRETTPF KCYAFSYGAQ ASSFNCEMSD
LDQTELKLDV HYTHTKERDY WLFAWNPFDW TCRDKVNTIG GSRVNNDRRM DIFREPGDVA
WRHYTVSGKP CRRSSPCEKN LITGFYSCET DGSEIGSWDY CCKTDHPCGY SRGFDYPWCF
VGDEADQWRK CSDRYYPGSN STKPSTHSNL GLPSGGKQKP KHHQQATAAS SEYTQHPPRP
GGLQSLSDFA AARLWPVTYL YSEGPPNATE FSNFVDCNKE TC
//