ID B4LPA2_DROVI Unreviewed; 1718 AA.
AC B4LPA2;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDW60211.1};
DE EC=2.7.10.1 {ECO:0000313|EMBL:EDW60211.1};
GN Name=Dvir\GJ21359 {ECO:0000313|EMBL:EDW60211.1};
GN ORFNames=Dvir_GJ21359 {ECO:0000313|EMBL:EDW60211.1};
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244 {ECO:0000313|EMBL:EDW60211.1, ECO:0000313|Proteomes:UP000008792};
RN [1] {ECO:0000313|EMBL:EDW60211.1, ECO:0000313|Proteomes:UP000008792}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; CH940648; EDW60211.1; -; Genomic_DNA.
DR RefSeq; XP_002049018.1; XM_002048982.2.
DR SMR; B4LPA2; -.
DR STRING; 7244.B4LPA2; -.
DR EnsemblMetazoa; FBtr0237284; FBpp0235776; FBgn0208487.
DR eggNOG; KOG1095; Eukaryota.
DR HOGENOM; CLU_001878_1_0_1; -.
DR InParanoid; B4LPA2; -.
DR OMA; NTACERQ; -.
DR PhylomeDB; B4LPA2; -.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0031594; C:neuromuscular junction; IEA:EnsemblMetazoa.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098794; C:postsynapse; IEA:EnsemblMetazoa.
DR GO; GO:0071212; C:subsynaptic reticulum; IEA:EnsemblMetazoa.
DR GO; GO:0061176; C:type Ib terminal bouton; IEA:EnsemblMetazoa.
DR GO; GO:0061177; C:type Is terminal bouton; IEA:EnsemblMetazoa.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0007411; P:axon guidance; IEA:EnsemblMetazoa.
DR GO; GO:0042051; P:compound eye photoreceptor development; IEA:EnsemblMetazoa.
DR GO; GO:0048565; P:digestive tract development; IEA:EnsemblMetazoa.
DR GO; GO:0007498; P:mesoderm development; IEA:EnsemblMetazoa.
DR GO; GO:0045792; P:negative regulation of cell size; IEA:EnsemblMetazoa.
DR GO; GO:1900074; P:negative regulation of neuromuscular synaptic transmission; IEA:EnsemblMetazoa.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:EnsemblMetazoa.
DR GO; GO:0040008; P:regulation of growth; IEA:EnsemblMetazoa.
DR GO; GO:0090328; P:regulation of olfactory learning; IEA:EnsemblMetazoa.
DR GO; GO:0099540; P:trans-synaptic signaling by neuropeptide; IEA:EnsemblMetazoa.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:EnsemblMetazoa.
DR GO; GO:0007522; P:visceral muscle development; IEA:EnsemblMetazoa.
DR CDD; cd00112; LDLa; 1.
DR CDD; cd06263; MAM; 2.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR002011; Tyr_kinase_rcpt_2_CS.
DR PANTHER; PTHR24416:SF604; RECEPTOR PROTEIN-TYROSINE KINASE; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF12810; Gly_rich; 1.
DR Pfam; PF00629; MAM; 2.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS50060; MAM_2; 2.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000313|EMBL:EDW60211.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1718
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002812924"
FT TRANSMEM 1123..1147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 304..469
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 522..710
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 1141..1410
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 37..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 89..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 1175
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1718 AA; 185692 MW; 2DC74BC82D9C6A7C CRC64;
MPRPLVLMLS LVLVLLSGPV WAQRPLLNHT FNSLPMSQHQ SNSYNNYNYQ GPGKQLRNGR
LHEQPQPLPL PTLPGLAQPV HVYDDYEGEA SAGTFGSRPP PGSRRDTRRR LNLSHVGAGG
APRPERGNGQ RGIESLRKEL MKPSVGGPGG GISGSSAGYA SYSATSSIGK IDGLGGIGSA
DRYGERLRQP TGAAAMTAGP ATGPYSTRFP PLYAGLDSQP IRTYPRKNSI SELLKLKKSF
NQADEPAGGV THGNMEGDTD ADVDQIDPIQ QIKERIRDTA PKPNTYSPHT ESTPSTEIED
LLGVKCNFET PCAWIWTENL SDGFQVLSGT ELAKKNMTGL LPGPVADSID DANGHFLYAR
VQPTTKQLNL TSPSFSTTLE KCYLEVYMHQ SDMSHGLSRV VVEPLHPQES SWVPAEIQGD
NFRSWTHKIF RLGRISRDFR IVFEIVPELK QGQKAHVALD NLRMVNCFPE GTKSEKCSTS
QVKCMMNKVP VCIPLPRICD ITRDCDDAED ELQSCDKIPY GGRCDFEDDW CGWRDSGRTT
LIWSRHTGSS PTHDTGPDGD HTQQHLLNTT GGYYMLVNMN QHINNTEKSS IIGFASNAIM
LSKNFNPPPS VHGNPDSPYR NSCVVRFYIH QFGKNPGSIN LSVVEMKEKE NITTTLWWSS
KNQGSDWLRA EYVLPNITSK YYLQFEARMG MRIFSDVAVD DFSLSPECFG LNIPEEHLNG
YNYWDVRQNL KSPTHHDFDH TNYLELTTCD TRGMIGPTQT QCESAYKEQN QSHVLREVHV
VEDQSTYKGM QKWKVPNEGH YTIIAKGASG GLGSGGVGSS RGSVAVAVLE LLKNEELYFL
VGQQGENACI KSMGVHKEAG CGTEHDLDLG QYSFRSKQDM VKNIYIENGA GGGGGGSFVF
LLNQAKNEAV PLLVAGGGGG LGIGQYIDED FQHGQKAKPL QAPESGQIHG EQLNKKTAGP
GGGWRAKEDQ ALSPTYGAAL LQGGRGGHSC YVELADNGTT VHRHGQGGFG GGGGGCNTGG
GGGGYAGGDV YLNESNGEGG SSYISNSRSL RDASEIYAGA SSGSGAIIII PAIEGCGCDY
RCVALDEFRS KVRCICPDGW SLKRDNNTAC ERQEEAGKSS FQYLVSILMV SLAVLFICIA
ALIFIALGKG AFGEVYLALY RHRDGDAVEM PVAVKTLRED PKREKEEDFL KEAAIMAKFN
HPNMVHLIGV CFDRQPYYIV LELLAGGDLQ KFLRENRNTP ERPSLLTMKD LLFCALDVAK
GCRYMESKRF IHRDIAARNC LLSSKGPGRV VKIADFGMSR DIYRSDYYRK GGKAMLPIKW
MPPEAFLDGI FTSKTDVWSF GILLWEVFSL GRSPYPGQHN TQVMELVVRG GRLGSPTECP
VSIYKIMADC WNPTPEDRPT FTSLLEHLTA CTQDASIMNA PLPNILGPTA SERDETVIRP
PNGDEFCLAV PDYLVPLPGN GMPHAPGGVG GSYAPTVQRQ QNTCTPPAVT SPAAPKPPPM
PEHLEGAAAL NGGGSDCWET SFILPNSKSD QPLLSAGAIT TMASGDSQRN LQAAAAVASM
AASATATPIL RSPTHSDEAK LISLDTPQPT PTTIQPPLSF ASQLDGITLD PAALTKSLTN
GGAHNGATGP TGGAAVGVAL GVAANGIAKQ SYANVQVQLK GEQERECSKL NGSLPTGNGA
IINGETAAGG ASANDSPFTI QGYAERYKDN NNHSEISC
//