ID ARMET_DROVI Reviewed; 173 AA.
AC B4LX78;
DT 19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 70.
DE RecName: Full=Mesencephalic astrocyte-derived neurotrophic factor homolog;
DE AltName: Full=MANF/CDNF-like protein;
DE Flags: Precursor;
GN Name=Manf {ECO:0000250|UniProtKB:Q9XZ63}; ORFNames=GJ23764;
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244;
RN [1] {ECO:0000312|EMBL:EDW66730.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87 {ECO:0000312|EMBL:EDW66730.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Required during the maturation of the embryonic nervous
CC system for maintenance of neuronal and cuticular connectivity.
CC Essential for maintenance of dopaminergic neurons and dopamine levels
CC (By similarity). {ECO:0000250|UniProtKB:Q9XZ63}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9XZ63}.
CC -!- SIMILARITY: Belongs to the ARMET family. {ECO:0000255}.
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DR EMBL; CH940650; EDW66730.1; -; Genomic_DNA.
DR RefSeq; XP_002053210.1; XM_002053174.2.
DR AlphaFoldDB; B4LX78; -.
DR SMR; B4LX78; -.
DR STRING; 7244.B4LX78; -.
DR EnsemblMetazoa; FBtr0239689; FBpp0238181; FBgn0210861.
DR GeneID; 6630749; -.
DR KEGG; dvi:6630749; -.
DR eggNOG; KOG4154; Eukaryota.
DR HOGENOM; CLU_099080_1_0_1; -.
DR InParanoid; B4LX78; -.
DR OMA; WSMPADK; -.
DR OrthoDB; 49731at2759; -.
DR PhylomeDB; B4LX78; -.
DR ChiTaRS; Manf; fly.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblMetazoa.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0042417; P:dopamine metabolic process; IEA:EnsemblMetazoa.
DR GO; GO:0070050; P:neuron cellular homeostasis; IEA:EnsemblMetazoa.
DR GO; GO:0031175; P:neuron projection development; IEA:EnsemblMetazoa.
DR GO; GO:0001963; P:synaptic transmission, dopaminergic; IEA:EnsemblMetazoa.
DR Gene3D; 1.10.720.30; SAP domain; 1.
DR Gene3D; 1.10.225.10; Saposin-like; 1.
DR InterPro; IPR045333; ARMET-like.
DR InterPro; IPR019345; ARMET_C.
DR InterPro; IPR045332; ARMET_N.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR036361; SAP_dom_sf.
DR PANTHER; PTHR12990; ARMET-LIKE PROTEIN; 1.
DR PANTHER; PTHR12990:SF5; MESENCEPHALIC ASTROCYTE-DERIVED NEUROTROPHIC FACTOR HOMOLOG; 1.
DR Pfam; PF10208; ARMET_C; 1.
DR Pfam; PF20145; ARMET_N; 1.
DR SUPFAM; SSF68906; SAP domain; 1.
PE 3: Inferred from homology;
KW Developmental protein; Disulfide bond; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..173
FT /note="Mesencephalic astrocyte-derived neurotrophic factor
FT homolog"
FT /id="PRO_0000390946"
FT DISULFID 28..114
FT /evidence="ECO:0000250|UniProtKB:P55145"
FT DISULFID 31..103
FT /evidence="ECO:0000250|UniProtKB:P55145"
FT DISULFID 61..72
FT /evidence="ECO:0000250|UniProtKB:P55145"
FT DISULFID 148..151
FT /evidence="ECO:0000250|UniProtKB:P55145"
SQ SEQUENCE 173 AA; 20041 MW; 7540A6DD06A62933 CRC64;
MNTSHIVLMI CFIVGVGQTA LALKEDDCEV CVKTVKRFAD TLDDATKKDY KLIETAFKKY
CKTQKNKEHR FCYYLGGLEE SATGILNELS KPLSWSMPAE KVCEKLKKKD AQICDLRYEK
QIDLNSVDLK KLKVRDLKKI LNDWDESCDG CLEKSDFIKR IEELKPKYSR NEL
//
