GenomeNet

Database: UniProt
Entry: B4LXF6_DROVI
LinkDB: B4LXF6_DROVI
Original site: B4LXF6_DROVI 
ID   B4LXF6_DROVI            Unreviewed;      2259 AA.
AC   B4LXF6;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   24-JAN-2024, entry version 91.
DE   RecName: Full=DNA polymerase epsilon catalytic subunit {ECO:0000256|RuleBase:RU365029};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU365029};
GN   Name=Dvir\GJ24376 {ECO:0000313|EMBL:EDW67834.1};
GN   ORFNames=Dvir_GJ24376 {ECO:0000313|EMBL:EDW67834.1};
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244 {ECO:0000313|EMBL:EDW67834.1, ECO:0000313|Proteomes:UP000008792};
RN   [1] {ECO:0000313|EMBL:EDW67834.1, ECO:0000313|Proteomes:UP000008792}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA   Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA   Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA   Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA   Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA   Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA   Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA   David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA   Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA   Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA   Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA   Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA   Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA   Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA   Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA   Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA   Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA   Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA   Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA   Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA   McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA   Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA   Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA   Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA   Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA   Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA   Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA   Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA   Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA   Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA   Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA   Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA   Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA   Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA   Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA   Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA   Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA   Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA   Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA   Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA   D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA   Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA   Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA   Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA   Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA   Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA   Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA   Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA   Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA   Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA   Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA   Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA   Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA   Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA   Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA   Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA   Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: DNA polymerase II participates in chromosomal DNA
CC       replication. {ECO:0000256|RuleBase:RU365029}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU365029};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU365029};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU365029}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU365029}.
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DR   EMBL; CH940650; EDW67834.1; -; Genomic_DNA.
DR   RefSeq; XP_002054314.1; XM_002054278.2.
DR   SMR; B4LXF6; -.
DR   STRING; 7244.B4LXF6; -.
DR   EnsemblMetazoa; FBtr0240301; FBpp0238793; FBgn0211456.
DR   eggNOG; KOG1798; Eukaryota.
DR   HOGENOM; CLU_000556_0_0_1; -.
DR   InParanoid; B4LXF6; -.
DR   OMA; MLDQCRY; -.
DR   OrthoDB; 5475218at2759; -.
DR   PhylomeDB; B4LXF6; -.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:0008622; C:epsilon DNA polymerase complex; IEA:EnsemblMetazoa.
DR   GO; GO:0008296; F:3'-5'-DNA exonuclease activity; IEA:EnsemblMetazoa.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045004; P:DNA replication proofreading; IEA:EnsemblMetazoa.
DR   GO; GO:0090592; P:DNA synthesis involved in DNA replication; IEA:EnsemblMetazoa.
DR   GO; GO:0007113; P:endomitotic cell cycle; IEA:EnsemblMetazoa.
DR   CDD; cd05779; DNA_polB_epsilon_exo; 1.
DR   CDD; cd05535; POLBc_epsilon; 1.
DR   Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR   Gene3D; 3.30.342.10; DNA Polymerase, chain B, domain 1; 1.
DR   Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR013697; DNA_pol_e_suA_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR029703; POL2.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR10670; DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A; 1.
DR   PANTHER; PTHR10670:SF0; DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A; 1.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF08490; DUF1744; 1.
DR   SMART; SM01159; DUF1744; 1.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485, ECO:0000256|RuleBase:RU365029};
KW   DNA replication {ECO:0000256|RuleBase:RU365029};
KW   DNA-binding {ECO:0000256|RuleBase:RU365029};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW   ECO:0000256|RuleBase:RU365029};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU365029};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|RuleBase:RU365029};
KW   Metal-binding {ECO:0000256|RuleBase:RU365029};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW   ECO:0000256|RuleBase:RU365029};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365029};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365029};
KW   Zinc {ECO:0000256|RuleBase:RU365029};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU365029}.
FT   DOMAIN          1542..1945
FT                   /note="DNA polymerase epsilon catalytic subunit A C-
FT                   terminal"
FT                   /evidence="ECO:0000259|SMART:SM01159"
FT   REGION          1210..1261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1285..1312
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1969..1988
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1210..1238
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1298..1312
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2259 AA;  258737 MW;  FE8FC9346DFB0A95 CRC64;
     MAEAGKTKVL QNTGKFVSET RAEGDDFFNE AGYRQSREND KIDSKYGFDR VKDSQERTGY
     LINMHTNEVL DDDRRLVAAL DLFFIQMDGS RFKCTVAYKP YLLIRPEVNM HLEVARFLGR
     KYSGQIASLE HINKEDLDLA NHLSGLQQHY LKLSFLNQTA MTKVRRELMA AVRRNTEREK
     SNTYYMQMLA NSLAQSASGS DDGSGKRQQD YMDCIMDIRE HDVPYHVRVS IDLRIFCGQW
     YNIRCRSGVE LPVITCRPDI LDRPEPVVLA FDIETTKLPL KFPDAQTDQI MMISYMIDGQ
     GYLITNREII SSNIEDFEYT PKPEFEGNFI IFNEENEMQL LQKFFDHIME VRPHIVVTYN
     GDFFDWPFVE TRAAVYDLDM KQEIGFSKMR DGIYLSRPSI HMDCLCWVKR DSYLPVGSQG
     LKAVAKAKLR YDPVELDPED MCRMAVEEPQ VLSNYSVSDA VATYYLYMKY VHPFIFALNT
     IIPMEPDEIL RKGSGTLCET LLMVQAYHAN IVFPNKHQSE LNKLSNEGHV LDSETYVGGH
     VEALESGVFR ADIPCRFRLD PNMVKQLMDQ VDAVLKHAIE VEESIPLQLV SNLDEVKQEI
     VQALQGLHDI PNRLEQPVIY HLDVGAMYPN IILTNRLQPS AMVTELDCAA CDFNKPGVRC
     KRSMDWLWRG EMLPASRNEF QRIQQQLETE KFPPLFPGGP ARAFHELSKE DQAAYEKKRL
     SDYCRKAYKK TKITKLETRN STICQKENSF YVDTVRAFRD RRYEYKGLTK TAKASVNAAI
     ASGDAAEIKA AKGREVLYDS LQLAHKCILN SFYGYVMRRG ARWHSMPMAG IVCLTGSNII
     TKAREIIERV GRPLELDTDG IWCILPGSFP QEFTVHTTHE KKKKINISYP NAVLNTMVKD
     HFTNDQYHEL RKAEKGEPPS YDIRDENSIF FEVDGPYLAM VLPAAKEEGK KLKKRYAVFN
     FDGTLAELKG FEVKRRGELQ LIKNFQSSVF EAFLAGSTLE ECYASVAKVA DYWLDVLYSR
     GSNLPDSELF ELIAENKSMS KKLEEYGAQK STSISTAKRL AEFLGEQMVK DAGLACKYII
     SKKPEGAPVT ERAVPLAIFQ SEPSVRRHHL RRWLKDNTMG DADIRDVLDW NYYIERLGGT
     IQKIITIPAA LQGLANPVPR VQHPDWLHKK MLEKNDVLKQ RRINEMFTSR PRPKPALATE
     DKQLELGDME DLAGKEDAEA SGRPIVTKRK RVHLDDDDEE GNAAESTPQP KTWRQALGAP
     PAIGETRKTI VEWVRFQKRK WAWQQEQRQR CRQQSKRQRN GTETAAGAAS AQAAARATTS
     AATLGGFLRR AQRTLLDQPW QILQLVPVND LGQFTVWALI GEELHRIKLT VPRIFYVNQR
     SAAPPEEGQL WRKVHRVLPR SRPVYNLYRY SVPEQLFRDN CLGMLADLAT PDIEGIYETQ
     MTLEFRALMD MGCICGVERE EARRLALLST RELENFSIEQ LEQRPQSHIR YLQHASSKLR
     KIYLYQHNIP TAKKEIWALF LLPSKKALVF ALDTVRANQM PNMKQLYVAE RLALIKNLQQ
     AAQIEKLPAE DFSFEVLIEV DVKQIYRHIQ RALSAYKQEQ SGPTMLCLQT AIEARKLSAA
     MPVLLEFPQA QIHISDDASL LSGLDWQRQG ARAVVRHFLN LNNVLELMLD QCRYFHVPIG
     NMPPDTVLFG ADLFFARLLQ KHNFVLWWSA STRPDLGGRE ADDSRLLAEF EESITVVQNR
     AGFYSDVCVE LALDSLAVSA LLQSNRIQEM EGASSAITFD VMPQASLEEM IGTVPAATLP
     SYDETALCSA AFRVMRSMVN GWLREVSINQ NIFSDFQIVH FYRWVRSSNA LLYDPALRRS
     LNNLMRKMFL RIIAEFKRLG ATIVYADFNR IIISSGKRNV PDALGYVDYI VQSLRNKEMF
     HSIQLSFEQC WNFMLWLDQS NFSGIRGRLP KGIDETVSAI AVGSTTLRQS QARNEQVHED
     DDDDNDDVQE VEAGLDEPLE EQEEEEEEEL SLELNWTIGE QLPEENECRE KFESLLTLFM
     QALAERKTTE QAIKDISHCA FDFVLKLHKN YGKGKPSPGL DLIRTIVKVL SVDKALADQI
     NELRRNMLRL VGVGEFSDLA DWTDPCDTYI INEVICKACN HCRDLDLCKD KHRAMKDGIP
     VWLCAQCYVA YDNEEIETRM IDALQRKMMS FVLQDLRCER CNEIKRENLA EFCTCAGNFL
     PLISGKEIET LLKTFSNVAG YHKMQLLQQT VQQAQKTPR
//
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