ID B4LYP8_DROVI Unreviewed; 1367 AA.
AC B4LYP8;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Exocyst complex component Sec8 {ECO:0000256|RuleBase:RU367079};
GN Name=Dvir\GJ23889 {ECO:0000313|EMBL:EDW66975.2};
GN ORFNames=Dvir_GJ23889 {ECO:0000313|EMBL:EDW66975.2};
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244 {ECO:0000313|EMBL:EDW66975.2, ECO:0000313|Proteomes:UP000008792};
RN [1] {ECO:0000313|EMBL:EDW66975.2, ECO:0000313|Proteomes:UP000008792}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC exocytic vesicles with fusion sites on the plasma membrane.
CC {ECO:0000256|RuleBase:RU367079}.
CC -!- SIMILARITY: Belongs to the NDRG family.
CC {ECO:0000256|ARBA:ARBA00005598}.
CC -!- SIMILARITY: Belongs to the SEC8 family. {ECO:0000256|ARBA:ARBA00010470,
CC ECO:0000256|RuleBase:RU367079}.
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DR EMBL; CH940650; EDW66975.2; -; Genomic_DNA.
DR RefSeq; XP_002053455.2; XM_002053419.2.
DR SMR; B4LYP8; -.
DR ESTHER; drome-GH02439; Ndr_family.
DR EnsemblMetazoa; FBtr0239814; FBpp0238306; FBgn0210984.
DR GeneID; 6630511; -.
DR KEGG; dvi:6630511; -.
DR eggNOG; KOG3691; Eukaryota.
DR HOGENOM; CLU_012416_0_0_1; -.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0000145; C:exocyst; IEA:UniProtKB-UniRule.
DR GO; GO:0006893; P:Golgi to plasma membrane transport; IEA:UniProtKB-UniRule.
DR GO; GO:0006612; P:protein targeting to membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
DR GO; GO:0090522; P:vesicle tethering involved in exocytosis; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR004142; NDRG.
DR InterPro; IPR039682; Sec8/EXOC4.
DR InterPro; IPR007191; Sec8_exocyst_N.
DR InterPro; IPR048630; Sec8_M.
DR PANTHER; PTHR14146; EXOCYST COMPLEX COMPONENT 4; 1.
DR PANTHER; PTHR14146:SF0; EXOCYST COMPLEX COMPONENT 4; 1.
DR Pfam; PF03096; Ndr; 1.
DR Pfam; PF20652; Sec8_C; 1.
DR Pfam; PF04048; Sec8_N; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483, ECO:0000256|RuleBase:RU367079};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|RuleBase:RU367079};
KW Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367079}.
FT DOMAIN 408..518
FT /note="Exocyst complex component Sec8 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04048"
FT DOMAIN 644..819
FT /note="Exocyst complex component Sec8 middle helical
FT bundle"
FT /evidence="ECO:0000259|Pfam:PF20652"
FT REGION 811..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1052..1075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 812..826
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1367 AA; 153898 MW; D25BAB6B3696CE50 CRC64;
MSAIAADKRA SFARRAESLV ERVRVLKTIY EKYNISTEKC GDLTVIVQGD LSQQEKRAVF
ITVHDLGCNH NSFQEFVSSP CMTEIKERSC FIHVDVPGHA DNAEALSDGF PFPSLQALGE
DLVTVLDYLH VKYVIGLGEG AGANVLARFG LAHPSRALGL ILINATGSAA SVLQSFRNKF
ISWKSDEVAH SAESFLMYHK FGHQIVGENP DKDKIVAEYQ KRLHRSLNSK NVGLYVKAFM
NRKDLTLKGC KVDVILITGM LSPYASMVEK LHRDVEKERV TILKIERAGD VLADAPSKVA
QSILLFCKGQ GLLTSIVMPG VDRGRSYSTA SSGSFERRLS RGISMEDYDK PNIRRLSIMN
IKKTFSDNFN FKRICMDAPP PTKPPRGVKY GKDESASCGF LVNVIKSLGF SETTEERQKE
KQKIEQEFKR SDLRLNELVS RHDQQLTQVL PLFSQVSTEV TASRERIHAV KENLGACKRL
LQCRRDELKK MWTDAVQHKY VLEMLEQIQE LRKVPQRVVS YTAKRQYLHA SKALTDALAT
LNGPLAGVEG LSDLRTDLQT RRQQLYHRLH EELVTQVYKN SANEAFQRSN SSRLNSSFTR
GIGARRSTDR IEANARVRKA LSEMAQGFEL DKAEIIEDAD LIDPELSMNY FIAIIVECFG
MLQKVPDSLE TLRVQIQTEL LNVVRQTTHQ LASGGTLQAS AGANNPLLTL LEIIFKQFKA
IAKTHTLLLK NYLAVGQKYA VVGPQSYDLT DFWAQAQSVL QLLLTDYLDI QNASADESSQ
TGFVEPINNI NSYFLRRKVP STKKAMFKFD KSSHGNVNSS SNSNSTHEPF KEHRRNASDA
SVDDNLVVNL LGSSKGSLTG LLPHEKKQRE KLLICTPDQN VITKVYLPIM GYIQEIENFM
KCKPGQPCSL HDFVDNYIKD TFLSKGHNRN LQLTIESLSK NQDAWRAIIT PEEMKSLNLS
RPLLQSTVMV ERRLVETKNL IEDLPCYSEE LLKMVCALLK AYREICQAAY RGIVQPDSED
KRIYSVAWLK DEDISRFLKT LPNWTDLKTS SQRARHTRKL QRGNFEPSEE ESPLQVQQRN
IREAEMLTSN LGEGGITQQE ILADISVLKE LAILQESMEW FSCRVSEFAN ELRRPLVNGL
NAAAADCAAN VAIKDGTIKV MTNLALEFDE LANTCLLVLH LEVRVQCFHY LRSKSSVKTN
SYVGSKDDIL EPDRQVLVLT KRLSEMDEAF SATLHPRKTR YIFEGLAHLA ARILIQASNY
LENIDQITVQ RMCRNSIALQ QTLSNITASR EIALDQAKHF YELLCMEPDE ILNALLERGT
QFSEMQLLNA LQLSCKACGI TDVNLLASYQ QKLSDILGAK PSKGVVV
//
