GenomeNet

Database: UniProt
Entry: B4M357
LinkDB: B4M357
Original site: B4M357 
ID   UBA5_DROVI              Reviewed;         400 AA.
AC   B4M357;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   16-JAN-2019, entry version 56.
DE   RecName: Full=Ubiquitin-like modifier-activating enzyme 5;
DE            Short=Ubiquitin-activating enzyme 5;
GN   ORFNames=GJ19153;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: E1-like enzyme which activates UFM1. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family. UBA5
CC       subfamily. {ECO:0000305}.
DR   EMBL; CH940651; EDW65232.1; -; Genomic_DNA.
DR   RefSeq; XP_002055031.1; XM_002054995.2.
DR   SMR; B4M357; -.
DR   STRING; 7244.FBpp0233570; -.
DR   PRIDE; B4M357; -.
DR   EnsemblMetazoa; FBtr0235078; FBpp0233570; FBgn0206298.
DR   GeneID; 6631874; -.
DR   KEGG; dvi:Dvir_GJ19153; -.
DR   FlyBase; FBgn0206298; Dvir\GJ19153.
DR   eggNOG; KOG2336; Eukaryota.
DR   eggNOG; COG0476; LUCA.
DR   InParanoid; B4M357; -.
DR   KO; K12164; -.
DR   OMA; ETHNYNI; -.
DR   OrthoDB; 1092362at2759; -.
DR   PhylomeDB; B4M357; -.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   Bgee; FBgn0206298; Expressed in 1 organ(s), highest expression level in adult organism.
DR   GO; GO:0019008; C:molybdopterin synthase complex; IEA:EnsemblMetazoa.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR   GO; GO:0050905; P:neuromuscular process; IEA:EnsemblMetazoa.
DR   InterPro; IPR029752; D-isomer_DH_CS1.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   Pfam; PF00899; ThiF; 1.
DR   SUPFAM; SSF69572; SSF69572; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding;
KW   Reference proteome; Ubl conjugation pathway; Zinc.
FT   CHAIN         1    400       Ubiquitin-like modifier-activating enzyme
FT                                5.
FT                                /FTId=PRO_0000391950.
FT   ACT_SITE    243    243       Glycyl thioester intermediate.
FT                                {ECO:0000250}.
FT   METAL       219    219       Zinc. {ECO:0000250}.
FT   METAL       222    222       Zinc. {ECO:0000250}.
FT   METAL       296    296       Zinc. {ECO:0000250}.
FT   METAL       301    301       Zinc. {ECO:0000250}.
FT   BINDING      76     76       ATP; via amide nitrogen. {ECO:0000250}.
FT   BINDING      97     97       ATP. {ECO:0000250}.
FT   BINDING     120    120       ATP. {ECO:0000250}.
FT   BINDING     143    143       ATP. {ECO:0000250}.
FT   BINDING     177    177       ATP. {ECO:0000250}.
SQ   SEQUENCE   400 AA;  43994 MW;  F54C7F3150C94B95 CRC64;
     MSNAIDELQA IIAELKSELE EQKTCTRNAR ERIERMSAEV VDSNPYSRLM ALQRMNIVKD
     YERIRDKAVA IVGVGGVGSV TADMLTRCGI GKLILFDYDK VELANMNRLF FTPDQAGLSK
     VEAAARTLSF INPDVRIETH NYNITTVDNF DKFLSTISES GMQQGQPVDL VLSCVDNFEA
     RMAINAACNE NNLNWFESGV SENAVSGHIQ FIRPGDTACF ACAPPLVVAE NIDERTLKRE
     GVCAASLPTT MGITAGLLVQ NALKYLLNFG EVSDYLGYNA LNDFFPKMTL KPNTQCDDRH
     CLQRQKEFQE RPKPVLQQVE EVSDEPLHAS NDWGIELVAD DAPVAEQAPK ATDTANVASG
     LRLAYEAPEK EAVDQAGHAA AGDGMPETSL EDLMAQMKSM
//
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