ID B4M9E6_DROVI Unreviewed; 1397 AA.
AC B4M9E6;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=PLAT domain-containing protein {ECO:0000259|PROSITE:PS50095};
GN Name=Dvir\GJ17927 {ECO:0000313|EMBL:EDW57822.1};
GN ORFNames=Dvir_GJ17927 {ECO:0000313|EMBL:EDW57822.1};
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244 {ECO:0000313|EMBL:EDW57822.1, ECO:0000313|Proteomes:UP000008792};
RN [1] {ECO:0000313|EMBL:EDW57822.1, ECO:0000313|Proteomes:UP000008792}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR EMBL; CH940654; EDW57822.1; -; Genomic_DNA.
DR RefSeq; XP_002057749.1; XM_002057713.2.
DR STRING; 7244.B4M9E6; -.
DR EnsemblMetazoa; FBtr0233852; FBpp0232344; FBgn0205094.
DR GeneID; 6634282; -.
DR KEGG; dvi:6634282; -.
DR eggNOG; ENOG502QUWX; Eukaryota.
DR HOGENOM; CLU_003575_0_0_1; -.
DR InParanoid; B4M9E6; -.
DR OMA; LGTYTNY; -.
DR OrthoDB; 52189at2759; -.
DR PhylomeDB; B4M9E6; -.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR PANTHER; PTHR46730:SF1; PLAT DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46730; POLYCYSTIN-1; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF02010; REJ; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50095; PLAT; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1397
FT /note="PLAT domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002817510"
FT TRANSMEM 1111..1134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1365..1383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1159..1276
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
SQ SEQUENCE 1397 AA; 160134 MW; F64F6BE1EC15FB9B CRC64;
MDLSRHTFMV LVLVLLIHIR NTRAVDEDAL SECQLMLYAN SEVTFGVETK LLVTLAEYPK
TTVVLRVSTA RYLVAYWEIG RGAKPMRPSF TYSRKIGNDL KRRNIEPSVP VSYQTGFYAE
LKATFFESAN ITLKLEGTAP LKKDVEPVQV VLSVFINTSS NCTPELSVMH CSNPAFPQQV
IITRSILFRA FFFRSCGLSD TMLTWSVMDV LGKETLKSYP DEDLAFNLKS YELRYSMQFE
LWRNLYMLYV EGIFNGEKYG ARCYLKAQQE KLEVIISGGT SREAFRGSKI TLDGSLSRDY
AKRPKETQFK VYNWDCFSYD DYYNTACRPD VSRVKKFGIA AYSLTLGCRY IFSLKLMSDY
DSDLKAVATQ TITAVDTESL HIVIVCISNC YHNMYNPMNK VLLAGKCLNC QKVQTRYDWY
LDEHNVHTSK KLSMIITTDK TMASIKLVVR TNDGRSGSEV KSLTQSVPPL GGTCSVTPFK
GIEAITQFLV CCTNFQARNN PIEFFYYAER VLLNRCQDCG CSIHLPHNLN FIKVLICDSL
FTCVRRLVRV TVTPLMHMPG DSPEALRAFI TRPPNDVVNL ATQGHMLRFL QTIQSLAAGV
TNAESGMILI DAFNNINLES LSALGKLANL THTLAVHLTP IDENEQVVLI RSLTILNKIF
QSVHNNDMNR MLVEEPFVNV TVACVTVYNI MNRLNSQIPR PPQGIYDKYY AALKKHKLDQ
SVVDRLMATI SGYNNEDAKQ RSMAWLNSTW ETERLYRFLF FARKHGMQPD YGGTNVDGLS
LEVKCFNITP GRTYTIETTD HMHKVYFSPE LLQEVKKPHK NEICIKVIST IRELNWWYPE
EKQPSAVLLS VRIYHERDDF KVERLLHHSK LSFRTIIGKY KPAMDRPNVV AGKKPVGSKI
IGTARFQTKA IDEDESEDFI AETGKYINCL TDGKLESMQK VLIYRVNVDE TSMVAVRFTQ
TTHKLQVLLI FGDLPKHLRE SIAKSGCIVP ANSQNTTMLL RNNCMQSHRV YVAVQVYGGS
EYEAKFSTPV PNGPAFFSFV FQLRSCDYWM YSLSGDSQRW GHTYCQPGME YPKKGSMNCM
CTVLGTYTSY VYHVPAIAVP STGYLPVMTH WYIVVAYFIL FVVVTLWLAI LFLYHNERPS
KTVVCDMAGL EDEAHRDVHD VLVFLKTGGR NNALTTATVR LIFQTTNRNE LQFTLMQDPE
RPELTRNSTY ILWLRTRDIR IPTRVAVVHN NGGRYPSWFL RRIEVMDVQA QLTQVFIVQR
WVHQKFLILS SSMVLRPGDD TVTESWRERF NTEFERQWIN WGLWQPVAGK WRESAAFDSL
TRAERVCIFL NKMMVTYCVC ACYMGPTTPE TVYADRRNLI QYRDLLSMFL ICSVLTNLIH
YVLEKLVLRK HKNSMLS
//
