ID B4MDC5_DROVI Unreviewed; 5209 AA.
AC B4MDC5;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 27-MAR-2024, entry version 112.
DE RecName: Full=Cadherin-related tumor suppressor {ECO:0008006|Google:ProtNLM};
GN Name=Dvir\GJ16197 {ECO:0000313|EMBL:EDW71186.2};
GN ORFNames=Dvir_GJ16197 {ECO:0000313|EMBL:EDW71186.2};
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244 {ECO:0000313|EMBL:EDW71186.2, ECO:0000313|Proteomes:UP000008792};
RN [1] {ECO:0000313|EMBL:EDW71186.2, ECO:0000313|Proteomes:UP000008792}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; CH940661; EDW71186.2; -; Genomic_DNA.
DR RefSeq; XP_002059128.2; XM_002059092.2.
DR SMR; B4MDC5; -.
DR STRING; 7244.B4MDC5; -.
DR EnsemblMetazoa; FBtr0442478; FBpp0398946; FBgn0203382.
DR GeneID; 6635660; -.
DR KEGG; dvi:6635660; -.
DR eggNOG; KOG1219; Eukaryota.
DR HOGENOM; CLU_000042_1_0_1; -.
DR InParanoid; B4MDC5; -.
DR OrthoDB; 2961370at2759; -.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0016327; C:apicolateral plasma membrane; IEA:EnsemblMetazoa.
DR GO; GO:0045296; F:cadherin binding; IEA:EnsemblMetazoa.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016339; P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; IEA:EnsemblMetazoa.
DR GO; GO:0044331; P:cell-cell adhesion mediated by cadherin; IEA:EnsemblMetazoa.
DR GO; GO:0045317; P:equator specification; IEA:EnsemblMetazoa.
DR GO; GO:0048105; P:establishment of body hair planar orientation; IEA:EnsemblMetazoa.
DR GO; GO:0001737; P:establishment of imaginal disc-derived wing hair orientation; IEA:EnsemblMetazoa.
DR GO; GO:0016336; P:establishment or maintenance of polarity of larval imaginal disc epithelium; IEA:EnsemblMetazoa.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IEA:EnsemblMetazoa.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0007446; P:imaginal disc growth; IEA:EnsemblMetazoa.
DR GO; GO:0007447; P:imaginal disc pattern formation; IEA:EnsemblMetazoa.
DR GO; GO:0090176; P:microtubule cytoskeleton organization involved in establishment of planar polarity; IEA:EnsemblMetazoa.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:EnsemblMetazoa.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:EnsemblMetazoa.
DR GO; GO:0045571; P:negative regulation of imaginal disc growth; IEA:EnsemblMetazoa.
DR GO; GO:0046621; P:negative regulation of organ growth; IEA:EnsemblMetazoa.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:EnsemblMetazoa.
DR GO; GO:0035332; P:positive regulation of hippo signaling; IEA:EnsemblMetazoa.
DR GO; GO:0090251; P:protein localization involved in establishment of planar polarity; IEA:EnsemblMetazoa.
DR GO; GO:0035209; P:pupal development; IEA:EnsemblMetazoa.
DR GO; GO:0090175; P:regulation of establishment of planar polarity; IEA:EnsemblMetazoa.
DR GO; GO:0032880; P:regulation of protein localization; IEA:EnsemblMetazoa.
DR GO; GO:0035159; P:regulation of tube length, open tracheal system; IEA:EnsemblMetazoa.
DR CDD; cd11304; Cadherin_repeat; 34.
DR CDD; cd00054; EGF_CA; 4.
DR CDD; cd00110; LamG; 2.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 2.60.40.60; Cadherins; 34.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF445; CADHERIN-87A; 1.
DR Pfam; PF00028; Cadherin; 33.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF00054; Laminin_G_1; 1.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 34.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00282; LamG; 2.
DR SUPFAM; SSF49313; Cadherin-like; 34.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR PROSITE; PS00232; CADHERIN_1; 17.
DR PROSITE; PS50268; CADHERIN_2; 34.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 2.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 4642..4665
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 118..183
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 184..297
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 298..415
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 421..527
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 528..632
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 633..741
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 742..888
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 865..968
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 972..1075
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1076..1179
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1180..1304
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1305..1410
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1411..1515
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1516..1627
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1649..1744
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1746..1865
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1866..1966
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1967..2071
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2072..2213
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2213..2326
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2327..2432
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2433..2539
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2540..2644
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2645..2751
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2753..2858
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2859..2961
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2961..3061
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3062..3172
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3173..3278
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3279..3383
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3384..3488
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3489..3594
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3595..3700
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3709..3808
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 4059..4095
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4098..4136
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4138..4174
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4175..4366
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 4445..4624
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 4742..4764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4776..4803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4846..4915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4936..4988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5010..5056
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5086..5111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5179..5209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4848..4867
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4885..4915
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5036..5056
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5179..5198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 4085..4094
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4107..4124
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4126..4135
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4164..4173
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 5209 AA; 571456 MW; 1A43C1BDF9FA85D0 CRC64;
MLMDDNLRIP SSLFRFIEKM HSLLSVHGQR RGNILHLIVV TTFVLFQATE AASTLQLSAP
RGRSYATTYE QYAAFPRRRS SSPAGEMQSR AVDTSADFEV LEGQPRGTLV GFIPTKPKFT
YRFNEPPREF TLDQITGEVK TNVVLDREGM RSHYDLVVLS SQPTYPIEVR IKVLDINDNA
PEFPEPSIAV SFSESAVAGT RLLLDAATDA DIGDNGVTDH YEIVAGNLDN KFRLVTTTNP
SGDTSYLHLE TTGNLDRESR GSYQLNISAS DGGSPPRLGF LQVNVTILDV NDNPPIFDHS
DYSVTLNETV MPGSPVLQVM ASDNDLGDNS KLTYYLAETE HQFTVDPETG VISTTVRLNC
PQQTSQQPRE PIGKGHIQKS CVFTVFARDH GSPRQDGRTY VTVNLLDTND HDPIIRFQYF
PPTGRVATVD ENASNGTVVA AVSVIDSDDG LNGETTTRIV SGNELHHFRL EKTPLFHIVR
VNGVLDREEI SKYNLTVVAI DKGTPERKAI AYLIIDVNDV NDHEPVFEKS EYTAVLSELA
PTGTFVTSIV ATDEDTGVNA QVFYEILTGN ELKWFNIDTT TGLIVTTGPL DREVQASVEL
SISARDGGPN PKFAYTQLKV TILDENDEAP HFGQQELNVS LSEGVSPPTI VALLSATDND
QGTNGSVTFS LAPSVERLYP QQFAIDSITG QLMTRKALDR ETMANYEIFV IARDQGAPAP
QSATATVCLS ISDINDNSPE FYPKHYIYTL KEEADVAPNS MRTLLNVTAT DRDVGDNALI
TYNLESGGDN VFHVDSRTGA VIFAVRGDDA LKQLKKPYYK LRISARDSGE KRSLQDAVVE
IVMESKSTTL DFDAHNGYDF QVVEDPDQKM TKLGRDVGRV QVKRQPIFAD AAIEYVIIYG
DRAEYFAIDQ HSGRITTARR IDREAQAQYQ LVVMARSVNR SSSMSGFAYG KCNVHIAILD
LNDNAPNFAQ DRDTEASIWL PEDTAVGQEI YLSRARDRDA GVNSRIRYNF TYNPDQQFRI
NPATGVVYLQ KPVRADPGTV FYVEIIATDG GTPSLSSRLS LPVNIADVND HTPVFDHTSY
ETSLLETTKV NTRFFALAAS DSDLGPNGRI AYEIIDGNSD RKFGVFPDGF LFVRAPLDRE
ERDYYALTIS CSDAGTPSRS SVVPVVIHVI DENDNPPQFT NSTFTFNIPE NAPANTFVGK
LTAVDRDIGR NAELSFSVLS QSQDFKIDTH NGFIKTLRPF DREALVRSTG NSASVGDEER
NISSGGSNYI LLEAIVTDNG IPPLHDKVKV KVIITDVNDN APEFLRTPYQ VTISEDAPEG
THIMHIFTKD ADEGLNGDVY YTLVAGNEAN LFGLDSATGL LILAHRLDRE SQEIHRLTVV
ARDAAIKNSL TSSVNITITV LDDNDNAPEF TQSSSEISVL ETSPSGTELM RFRASDADQG
MNSQVVFSIT AGNRRDTFHI DSVSGSLYLH KPLDYEDITN YTLNITASDC GIPPLSTTVL
YNVVVVDDND NPPIFPSTAI VRQIKEGIAL KTPIVTVTAD DPDSGVNGKV TYVISRQEPE
TAGGRHFGIN TQTGVIYTLR EIDREAIDNF RLTVVATDQA QPSDRQLATE KLVTVIVEDV
NDNAPIFVSM NAAILPTLLN GSIPPGSIGG YVMQVLARDA DSSSNGLVTY EFAGGQQELF
HLHRNTGVIT LGSQGSQPQT KPNVRYQLTL RATDEASGER KSTETYITII TLGTSDGEGD
RPIFENHNAL FGSVYENEPI GTSILTVSAQ LEGTEIEYYV TNVTTSTSSI FGHASSSEMR
VQVDRLFDID AKLGILSTAV ELDREAGPSN YEIEVHAIAL GGKPRTARTK VQVTVLDKND
SPPKVLDTPL IYTVSEDLAI GHTIATIRAT DPDPDIMSSM VFTLINGHDG KFILEPSTGK
LQLRDSLDRE AKDKYNMRIR VSDGVQYTET DIIIQVDDTN DNPPVFEESV YSFDIPENAP
RGYQVGEIVA KDADLAQNAQ VSYAVVSDWA NDVFSLNPQT GALTLTAKLD YEDVQHYILL
VQAQDNGQPS LSTTITVYCN VLDLNDNTPL FDPMSYSSEI LENVLVGKEV VTVSAKDIDS
GNNGLIEFSI TAGDEDGDFW INSNGTISTR RQLDREHRSA YTLTVTARDC ADEMAIFSEL
KESQLKLKYR SPRRYNKKHQ QDQFLSHQKQ ERLSSTVQVT ILIKDVNDEA PVFVSANETT
VMENVAINTV VFTVKAIDND EGRNGYIDYY LDDKSRLSDD NGSAEPLPFT LNPTDGILRV
ADLLDRELRL NYVLNITARD RGDPPLATQS QLTIKILDVN DNIPVFDPKQ YSASVAENAS
IGAMVLQVSA TDMDEGDNGR VRYSIVSGDQ NRDFSISEDT GIVRVAKNLN YERKARYILT
VRAEDCAPKE SASDIAELII SIIDINDNRP TFLDSPYIAR VMENTLPPNG GYLLTVTAFD
ADTPPLNNQV RYFLKEGNAD LFRINASTGD IVLLGTLDRE LQNEYILTLV AMDTGSPPLS
NTGIVRVEVQ DINDNGPVFE LQYYHASIQE NLPVGSLVLK PVATDKDTGL NGKLRFDLLG
EHMSHFHIDT DTGEITTAAV LDRESIAVYQ LTLMAQDSSI IEPRATSVNL TIKVGDTNDN
VPKFEANNFN IVVPNNIRAG EFVFGARATD LDEGENAMVV YNINGKDQHI FEVHPSTGVI
RTKMELAQKY KPNVDIIYNI NIQATDQGYM SQISTAELTV QLRPVELFPV FSYMPITQFN
LPEDVQPGKM IAKLAASSPK KGSIANIRYK IAGGNMGNTA IVDSTTGVLS VGQDGLDYEL
AHQYEIWVAA ADSDRPSLRT VMKLTINVTD ANDNPPVMEK LIYNAEIMEE ETPPQLIVAI
KAKDRDSGEN GEVSYRLKND YNGTFEIVDS GEIYTTMRLD REEFSDYALV VEAVDQGVPQ
LTGTASVLLH LLDKNDNPPK FTRLYSLNVT ENAEIGSFVI CVTSSDLDLG ENANATYSFS
ENPGKKFKID SQSGNITVAG QIDREQQDEY ILKVVASDGA WRAETPITIT IQDQNDNAPE
FEHSFYSFNF PELQHAVAFV GQIIATDRDK QGPNSVISYS LQSPSPIFSV DPATGEIFSK
TQIQYKHSQY ISSPENMFAL TILATDNGKP PLYTECLVNI NIVDANNNPP KFEHTEYLSP
LPEQAGAGQR VVRVHANDDC DVGVNAEIDY SLISSNLSAY FTINKHDGWV TLIKQIKLPA
NSRFELNVRA TDRGVPPLSD QTRVIVVVTD ENRHAPEFNP RSYQVIVPEN EPIGTTIITV
SATDKDTGPN GMLHYAISGG NERNYFNVNE RTGAIIIMQP LDYDLMQEYH LNISVKDLGY
KALTALAMLT IILTDVNDNP PVFNQSEYHG YIAENKPVGT AVFQAHATDK DSPKNAIIHY
SFLARGTDHH FFSINVSNGT ILSTASFDYE ERRSYTLHIK AKNPDSSMES YAVLYVHVLG
VNEFYPQFVQ SAFHFDVSET SSVGTAVGSV QATDKDIGED GRIYYLLVGS SNDKGFGINT
NTGLIYVTRN LDRETQNRVV LMVMAKNYGS IRGNDTAEAQ VTISIQDGND PPEFVKRYYS
STILESVPPG TMVTTVKAID KDVRPQNNQF TYSIINGNIK QSFKIDAETG EISTAVLLDR
EDIAYYNLVI GAIDTGLPPQ TGTATVRIDL DDINDNGPTF SSDGLLGYIS ENEPAGTSII
TLAASDPDLP HNGAPFSYKI VGGKHKAWFT IDKYTGLVRS TASYDREATP LLEAIIEVED
SGSPKQQSQH KLVIKVLDQN DNPSTPRTVH VAVSIFNGDL PANTKLADVR PNDVDIVGDY
RCRLQGSGQL IIKSSCDLYT TSLTTPMSYL YDVTGNDGKH GDVSYKVTVD FQSFNNNTLA
NTLPLLLRNM SATQFLAHYY RQALEMLQSR FGPGDEILLY SLIEIDTNNA SNIDLEALFV
VRMSNLTYHQ PHQIVERLRE KRSSLSDLLH TDIVIGYEPC STPNVCANGG VCSATIRLLD
TSHFSIIDSP SLVLSGPRII HDYTCQCAKG YAGEQCARRQ DPCLPSPCQG QAQCRRMGND
YQCECPANRE GKECQKERSD VCWSKPCHNG GSCQRSPDGA SYFCLCRPGY RGSQCESITD
SCRPNPCLHG GLCVSLKPSY KCSCPSGRYG RHCERFSYGF EPLSFMSFPS LDPTTNDISI
VFATSKPTAL LVYNYGLQNG GRSDFLAIEL VKGQAVFSSG GSRTAISTVV AGLNLADGSW
HKVTATRNGR VMSLSIAKCT ESGEVCSECI PGDSSCYADD VVPMGTLNFN KQPLFIGGLQ
SADPVLERPG QIHSDDLVGC IHSVSINGRA LNLSSPIQQH GILPGCNRQA CQPALAAERC
SSYAGQCIDR WSTSLCQCGG ELLSPDCGDS LEPVKISSGG FVEFKISEQY RRMQLLDNLY
NGNNAWSSFG SRTKRLSLYN ASAVTTSFYD PPKVLSFLFR TYKSHGLIFY AATNQMYTTL
SLLNGKLVYY SKQHLSINMT VPEPAALNDG KWHNISLRSQ SHILHLLIDG HQVGEELDVA
GVHDFLDPYL STLCVGGASN VLINEEPFTG CIANFTINNE LQPLNGSGSI FHEVKQHGVV
ELGCKGTDIG VDAAQVADPL SIGITLVIVF FVILVVAIFG SYVIYRFRGK QEKIGSLSCG
VPGFKIKHPA PATQSQTADH VNSRSIHASD SPAPIVCNND HMRPPNHHLA GPELITKKFK
ERGDLPPTAD HSQPQQRPQR PDIIEREVVG KSPPIREEHH LSIPPPNPLH PLDHGSSVDL
GSEYPEHYDL ENASSIAPSD IDIVYHYKGY REAGGMRKYK ATTPPVASYT HHKHQSTAAQ
QQHRHSPRHA VSGPFVPRVP NQNNQPPPST SASRTHQTTP LARLSPSSEL SSQQPRILTL
HDISGKPLQS ALLATTSSSG GVGKDALHSN SERSLNSPVM SQLSGQSSSA SRQKPVAPPK
APTQTSMGLT AEEIERLNAR PRTCSLVSTL DLSSSSEAPT PRVPGGALHL SLGGDVDAHS
STSTDESGND SFTCSEIEYD NNSLSGDGKY STSKSMLDSR SPVARAISGE PSRNQNVSKT
PPIPPHAYDG FESSFRGSLS TLVASDDDLA NHLSGIYRKA NGNASPSATT LGWEYLLNWG
PSYENLMGVF KDIAELPDTT SSLQQQQQPA QPVSTLRIPN VQKPPEEYV
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