ID B4MF19_DROVI Unreviewed; 2069 AA.
AC B4MF19;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 118.
DE RecName: Full=Sema domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=Dvir\GJ14688 {ECO:0000313|EMBL:EDW71120.1};
GN ORFNames=DVIR88_6g0024 {ECO:0000313|EMBL:ACY70487.1}, Dvir_GJ14688
GN {ECO:0000313|EMBL:EDW71120.1};
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244 {ECO:0000313|EMBL:EDW71120.1, ECO:0000313|Proteomes:UP000008792};
RN [1] {ECO:0000313|EMBL:EDW71120.1, ECO:0000313|Proteomes:UP000008792}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSC#15010-1051.87 {ECO:0000313|EMBL:EDW71120.1}, and Tucson
RC 15010-1051.87 {ECO:0000313|Proteomes:UP000008792};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
RN [2] {ECO:0000313|EMBL:EDW71120.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TSC#15010-1051.87 {ECO:0000313|EMBL:EDW71120.1};
RX PubMed=18057021; DOI=10.1093/bioinformatics/btm542;
RA Zimin A.V., Smith D.R., Sutton G., Yorke J.A.;
RT "Assembly reconciliation.";
RL Bioinformatics 24:42-45(2008).
RN [3] {ECO:0000313|EMBL:EDW71120.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TSC#15010-1051.87 {ECO:0000313|EMBL:EDW71120.1};
RG FlyBase;
RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:ACY70487.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=15010-1051.88 {ECO:0000313|EMBL:ACY70487.1};
RX PubMed=20479145; DOI=10.1534/genetics.110.116129;
RA Leung W., Shaffer C.D., Cordonnier T., Wong J., Itano M.S.,
RA Slawson Tempel E.E., Kellmann E., Desruisseau D.M., Cain C.,
RA Carrasquillo R., Chusak T.M., Falkowska K., Grim K.D., Guan R.,
RA Honeybourne J., Khan S., Lo L., McGaha R., Plunkett J., Richner J.M.,
RA Richt R., Sabin L., Shah A., Sharma A., Singhal S., Song F., Swope C.,
RA Wilen C.B., Buhler J., Mardis E.R., Elgin S.C.;
RT "Evolution of a distinct genomic domain in Drosophila: comparative analysis
RT of the dot chromosome in Drosophila melanogaster and Drosophila virilis.";
RL Genetics 185:1519-1534(2010).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; CM000831; ACY70487.1; -; Genomic_DNA.
DR EMBL; CH940665; EDW71120.1; -; Genomic_DNA.
DR RefSeq; XP_002059722.1; XM_002059686.2.
DR SMR; B4MF19; -.
DR STRING; 7244.B4MF19; -.
DR EnsemblMetazoa; FBtr0230613; FBpp0229105; FBgn0201895.
DR GeneID; 6636253; -.
DR KEGG; dvi:6636253; -.
DR eggNOG; KOG3610; Eukaryota.
DR HOGENOM; CLU_001436_2_0_1; -.
DR InParanoid; B4MF19; -.
DR OMA; TPYFYET; -.
DR OrthoDB; 1387371at2759; -.
DR Proteomes; UP000008792; Chromosome 6.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd12205; RasGAP_plexin; 1.
DR CDD; cd11236; Sema_plexin_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF44; PLEXIN-B; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 4.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000008792};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..2069
FT /note="Sema domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014299007"
FT TRANSMEM 1397..1419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 86..560
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 1802..1927
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
SQ SEQUENCE 2069 AA; 232090 MW; ACF4DD8AE24341F7 CRC64;
MLQQIFCQHG AVYILDAFFL LLQLHSAVDC IKVEHANTHP HSHLEVYNKQ FPSSDIVAQF
ALPPIAGGVA GGIFDTGGGG SSTSTSTEAN FGNRTNSANR LGIGANSQSK NYFTHLTFDY
THNVLYAGAT NKILKLNENL RVLSEAVTGP KHDAPQCHAG GCPEDVETVL VNNFNKILVV
SYAHNDGILI SCGSIRQGAC EIYNLLRFPA APQFVAVPLA ANDEYASTYA FVGPARYSWK
EEDILYVGTT FTNVGDYRHD VPAISSRRLD DLNYAEFSIQ QSIINIDVKY RDHFLVDYVY
GFNSSEYAYF VLVQKKSHLA EEAGYVTRLA RICITDPNYD SYTEITIQCT ATDDHTDYNI
LRDAKITHAS QKLAYQMGIK RDDHVLVTVF SPSKDISDQP ENKSAMCIYS LKDIEDVFIE
NIHMCFNGTI KDRNLGYISG TINDGRCPIV GSLGNIYNFC NVGLKISGVA PISAHALFHF
DNVSVTSVTA TTTTDQQHSL AFLGTEAGTV KKVLLSGQNP GEYEEIVVDA GSRILPNTMM
SPKKDFLYVL STRKITKLRI EHCSVYSNCS ACLESRDPFC GWCSLEKRCT VRSTCQRDTS
ASRWLSLGSG QQCIDFESIV PDKIPITELT QVQLVIRTLP EPFNAKYRCV FGNSTPIDAE
ILEHGLACAT PPIDQRPSIA ANMDHILVPL SVRSSETNKD FVSRSFAFFD CSHHANCQSC
VRSSWGCNWC IFDNKCVHKL EQCRNMENAI SAEGQCPHLK RNRQPILLPV RVPKEIRLEI
ENLPKPKSAH AGYLCTIQIE AAQMLLPAHI ESNKIVVCEK TPYFYETNTH EYEAKVEITW
NRQHYVDTAT VILYKCDVLG SHREHADCSL CVTRDPKYQC AWCGSSCVYN ETCAGSVGHG
YDTATLGSAL PLQNECPRPR IDIIKPLSGP IEGGTLVTIE GSNLGIREED VRGKISIGTV
PCDLVNYQIS VKIECRTGAA LHEMSAPIKV ANDAGYTESS VQFHFKDVQL TGLYPTVGPK
SGGTQLSLLG KYLNIGSSIR AFLDEYECHI NVTQASSSRL SCITSEATQP EPIRSLRLVV
DGANRTFTCK SPDFGQQQLI STSRSYYGAY YNMPPPPCSI FNYTQDPRIM QIKPLRSFVS
GGRILTVHGM YLDSIQNPEL EVFFDNERVN KTSCTVINSS QMECPSPPVN LKFELLKSAI
ETSSKSEQGK DKSKRKRNAL FNDSFNIYAT GSTASSYFAS NSMDVAAFVK VHETQLNLQL
SFVMDNVQLV RDLNKYFHDI RSTIVYLTDP KYLPFPNNGI KLYKGDTLVI EGELLNLAAD
EYDVNVTIGT AQCNITSLAL TQLLCIPPEQ QPSATDENGV DQSTDLPLVV VKVGRNLRFV
IGYLKYDLNK PYALSHAMLG IILTVVSLII VLIVVLIMFR RKSTQAEREY KRIQIQMITL
ESNVRSECKQ AFAELQTDMT DLTADLESSG IPTLDHVNYI MKVFFPGVSD HPILNSPKMR
GNSQHTNYDT AMMQFEQLVS NKYFLLTFIE TLEAQRSSFS IRDRVNVASL LMIVLMNKME
YATEILKCLL LRLIEKSLAS KHPQLMLRRT ESVVEKMLTN YLAICMYDYL KEYAGSSLFL
LFKAIKHQVE KGLVDAITHD ARYSLSEERL LHEQVTHSVV ILHILQDDLD EKVQCRVNDW
DTISQVKLKI LDAIFKNTPF SMRPSVHEVD LEWRHGRGGH LTLQDEDLTT KTINGWKRLN
TLSHYGVKES AVMSLIARQN DSYNMPYSKQ QAPYHNFYYI NNSQSHIIIN NDIESGLQQP
RLYHLVKPII PDHYMNIKNS AMSGVLAPAQ GGTHCIVNGS ERVNKTIPEV YLTRLLATKG
TIQKFVDDFF SIILTVNEEL PPAVKWLFDL LDEAARRHNI AETDILHAWK SNSLPLRFWV
NFIKNPDFIF DVNKTYSVDS CLSVIAQTFM DACSTAEHRL GKDSPSNKLL FAKDIPNYRT
MVKEFYRDVA RLPQISDQEM STAMQQLSVQ QNEEFDTISA LKELYIYITK YREQIMDALD
SDPNCKKMHL SSKLESVACT LDGEDTSNC
//