GenomeNet

Database: UniProt
Entry: B4MLE8
LinkDB: B4MLE8
Original site: B4MLE8 
ID   CUE_DROWI               Reviewed;         651 AA.
AC   B4MLE8;
DT   13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   10-APR-2019, entry version 60.
DE   RecName: Full=Protein cueball {ECO:0000250|UniProtKB:Q95RU0};
DE   Flags: Precursor;
GN   Name=cue {ECO:0000250|UniProtKB:Q95RU0}; ORFNames=GK17203;
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260;
RN   [1] {ECO:0000312|EMBL:EDW72804.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24 {ECO:0000312|EMBL:EDW72804.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Has a role in spermatogenesis and oogenesis.
CC       {ECO:0000250|UniProtKB:Q95RU0}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass
CC       type I membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cueball family. {ECO:0000305}.
DR   EMBL; CH963847; EDW72804.1; -; Genomic_DNA.
DR   RefSeq; XP_002061818.1; XM_002061782.2.
DR   ProteinModelPortal; B4MLE8; -.
DR   SMR; B4MLE8; -.
DR   STRING; 7260.FBpp0246346; -.
DR   EnsemblMetazoa; FBtr0247854; FBpp0246346; FBgn0219202.
DR   GeneID; 6638883; -.
DR   KEGG; dwi:6638883; -.
DR   eggNOG; ENOG410IPSX; Eukaryota.
DR   eggNOG; ENOG410XPMR; LUCA.
DR   InParanoid; B4MLE8; -.
DR   OMA; ETPCFDP; -.
DR   OrthoDB; 520442at2759; -.
DR   PhylomeDB; B4MLE8; -.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0045938; P:positive regulation of circadian sleep/wake cycle, sleep; IEA:EnsemblMetazoa.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0070328; P:triglyceride homeostasis; IEA:EnsemblMetazoa.
DR   Gene3D; 2.120.10.30; -; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000033; LDLR_classB_rpt.
DR   Pfam; PF00058; Ldl_recept_b; 1.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00135; LY; 3.
DR   PROSITE; PS00022; EGF_1; 3.
DR   PROSITE; PS01186; EGF_2; 2.
DR   PROSITE; PS50026; EGF_3; 3.
DR   PROSITE; PS51120; LDLRB; 3.
PE   3: Inferred from homology;
KW   Cell membrane; Complete proteome; Differentiation; Disulfide bond;
KW   EGF-like domain; Glycoprotein; Membrane; Oogenesis;
KW   Reference proteome; Repeat; Signal; Spermatogenesis; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL        1     21       {ECO:0000255}.
FT   CHAIN        22    651       Protein cueball. {ECO:0000255}.
FT                                /FTId=PRO_0000386579.
FT   TOPO_DOM     22    540       Extracellular. {ECO:0000255}.
FT   TRANSMEM    541    561       Helical. {ECO:0000255}.
FT   TOPO_DOM    562    651       Cytoplasmic. {ECO:0000255}.
FT   REPEAT      115    162       LDL-receptor class B 1. {ECO:0000255}.
FT   REPEAT      163    207       LDL-receptor class B 2. {ECO:0000255}.
FT   REPEAT      208    253       LDL-receptor class B 3. {ECO:0000255}.
FT   DOMAIN      374    408       EGF-like 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      409    440       EGF-like 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      443    480       EGF-like 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   COMPBIAS    275    289       Thr-rich. {ECO:0000255}.
FT   COMPBIAS    550    557       Poly-Leu. {ECO:0000255}.
FT   CARBOHYD     77     77       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    102    102       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    114    114       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    183    183       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    324    324       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    482    482       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    499    499       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    383    396       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    398    407       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    412    421       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    416    431       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    447    457       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    451    468       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    470    479       {ECO:0000255|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   651 AA;  73571 MW;  216C66517CD3EBC2 CRC64;
     MILRLFILLS IITVYLQLSV GIQQQFEFAI TLKSKILFVD EHWNVVNTAA HEFDELSALT
     FDESEERIYF NDGQHQNSSI FSLRKVGKSN HLAEQTIQRY GNESVGGIAY DPLNRTIYWS
     DLLQKKIFYA SIDTVATEMP KILVDLSEEN GTPYGVAIDI CGRKLYWTNS NINHPTVERI
     DLNGTGRLAI IDKNIDSPRG IVVDQGAKRI FWIDDLKGIF FAVMSAQLDG SDVKLVLKDK
     NHEPQNLAVT RNAIYWTDRT TKSVWSHLKE PEIATTTTTT TTSTTQIPTV EGEEGTGAMD
     DNDIWPVGDF ETTPKKSPLE RKINLTEEAR GIVARTGFYQ LQKDSQCSKV IQLVKQRLDE
     SQQNNRVLNV VDEQLDELQR EHCLGGGTYY PQQKFCVCVP GYKGTRCETN ECHNFCVHGT
     CQISEMGYPK CYCQPGYSGE RCEVKKCLNF CQNGGDCQLD ELTGEASCQC PSNFGGLRCE
     HNSTEICGLF CRLLKHDSNT SVPFGCHDIC EQLAKDSSDL IAIPEYKHLD VCLAPNAWTG
     SVLMPLMISL ILILLLLTIF IHGLRRLYKP KRPHIKKTFV VRKQARTNSS SDTPLTNRPL
     ATEQCEITIE NCCNMNICET PCFDPKLVEF AKSNCKDDKK ILIHNMEDDL Y
//
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