GenomeNet

Database: UniProt
Entry: B4MRV0_DROWI
LinkDB: B4MRV0_DROWI
Original site: B4MRV0_DROWI 
ID   B4MRV0_DROWI            Unreviewed;      1441 AA.
AC   B4MRV0;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   24-JAN-2024, entry version 97.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN   Name=Dwil\GK15893 {ECO:0000313|EMBL:EDW74839.1};
GN   ORFNames=Dwil_GK15893 {ECO:0000313|EMBL:EDW74839.1};
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260 {ECO:0000313|EMBL:EDW74839.1, ECO:0000313|Proteomes:UP000007798};
RN   [1] {ECO:0000313|EMBL:EDW74839.1, ECO:0000313|Proteomes:UP000007798}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24 {ECO:0000313|Proteomes:UP000007798};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA   Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA   Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA   Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA   Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA   Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA   Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA   David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA   Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA   Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA   Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA   Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA   Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA   Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA   Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA   Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA   Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA   Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA   Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA   Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA   McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA   Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA   Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA   Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA   Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA   Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA   Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA   Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA   Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA   Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA   Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA   Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA   Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA   Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA   Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA   Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA   Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA   Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA   Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA   Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA   D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA   Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA   Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA   Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA   Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA   Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA   Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA   Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA   Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA   Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA   Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA   Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA   Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA   Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA   Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA   Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA   Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC       {ECO:0000256|ARBA:ARBA00009634}.
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DR   EMBL; CH963850; EDW74839.1; -; Genomic_DNA.
DR   RefSeq; XP_002063853.1; XM_002063817.2.
DR   STRING; 7260.B4MRV0; -.
DR   EnsemblMetazoa; FBtr0246544; FBpp0245036; FBgn0217896.
DR   GeneID; 6640882; -.
DR   KEGG; dwi:6640882; -.
DR   eggNOG; KOG4641; Eukaryota.
DR   HOGENOM; CLU_004280_0_0_1; -.
DR   InParanoid; B4MRV0; -.
DR   OMA; NHVFIGR; -.
DR   OrthoDB; 927694at2759; -.
DR   PhylomeDB; B4MRV0; -.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   GO; GO:0009897; C:external side of plasma membrane; IEA:EnsemblMetazoa.
DR   GO; GO:0005030; F:neurotrophin receptor activity; IEA:EnsemblMetazoa.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:EnsemblMetazoa.
DR   GO; GO:0046790; F:virion binding; IEA:EnsemblMetazoa.
DR   GO; GO:0007411; P:axon guidance; IEA:EnsemblMetazoa.
DR   GO; GO:0051607; P:defense response to virus; IEA:EnsemblMetazoa.
DR   GO; GO:0009597; P:detection of virus; IEA:EnsemblMetazoa.
DR   GO; GO:0045087; P:innate immune response; IEA:EnsemblMetazoa.
DR   GO; GO:0040011; P:locomotion; IEA:UniProt.
DR   GO; GO:0002225; P:positive regulation of antimicrobial peptide production; IEA:EnsemblMetazoa.
DR   GO; GO:0010508; P:positive regulation of autophagy; IEA:EnsemblMetazoa.
DR   GO; GO:0050688; P:regulation of defense response to virus; IEA:EnsemblMetazoa.
DR   GO; GO:0008063; P:Toll signaling pathway; IEA:EnsemblMetazoa.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 6.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR24369; ANTIGEN BSP, PUTATIVE-RELATED; 1.
DR   Pfam; PF00560; LRR_1; 1.
DR   Pfam; PF13855; LRR_8; 5.
DR   Pfam; PF01582; TIR; 1.
DR   PRINTS; PR01537; INTRLKN1R1F.
DR   SMART; SM00364; LRR_BAC; 8.
DR   SMART; SM00365; LRR_SD22; 5.
DR   SMART; SM00369; LRR_TYP; 19.
DR   SMART; SM00082; LRRCT; 1.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 3.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS51450; LRR; 8.
DR   PROSITE; PS50104; TIR; 1.
PE   3: Inferred from homology;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007798};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..1441
FT                   /note="TIR domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002818602"
FT   TRANSMEM        1047..1070
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1096..1233
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
FT   REGION          1294..1325
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1360..1441
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1371..1394
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1403..1435
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1441 AA;  161220 MW;  5C429FD7659E9AFF CRC64;
     MEQTVLLLLL LPLMVVMMSG SRAALVPKER GNSDNSASAM LGGGAGAATV SLSSDYSSLL
     SAAVPVASSP APVHSGPNNQ CSWTYNGTSA VHCALRLIER QPGLDLQGAD GSSQLTIKCS
     DLYMFESTLP VAVFARLQTL ESLRLESCKL LQLPNNAFEG LTTLKSLRLS TRNGEWGPSK
     ALELYPDSLN GLKQLTELDL SENNLRALPA GFLCPVGNLQ SLNLTRNRIR TAEQLGFADM
     NCSGGSELQL LDASHNELRS ITESWGISRL RRLQHLNLQH NNISELSGEA LAGLSSLRIV
     NLSNNHMETL PEGLFAGSKE LREIHLQHNE LYELPKGLFH RLEQLLVVDL SGNQLTSNHV
     DNTTFAGLIR LIVLNLAHNA LTRIDYRTFK ELYFLQILNL RNNSIGHIED NAFLPLYNLH
     TLNLAENRLH TLDDKLFNGL YVLSKLTLNN NLISVVEPAV FKNCSDLKEL DLSSNQLNEV
     PRALQDLAML RTLDLGENQI RTFDNQSFKN LHQLTGLRLI DNQIGNITVG MFADLPRLSV
     LNLAKNRIQS IERGSFDKNF ELEAIRLDRN FLSDINGVFA TLVSLLWLNL SENHLVWFDY
     AFIPSNLKWL DIHGNYIEAL GNYYKLQEEI RVKTLDASHN RITEIGPMSI PNTIELLFIN
     NNLIGNVQPN AFVDKANLAR VDLYANQLSK LQLQQLRVAP VLAPKPLPEF YLGGNPFECD
     CTMDWLQRIN NLTTRQHPRV MDMPNIECVM PHARGAAVRP LSSLRPQDFL CRYESHCFAL
     CHCCDFDACD CEMTCPHNCT CYHDQIWSTN VVDCGGQQTM ELPRRVPMDS SIVYLDGNNF
     PVLKNHAFIG RKNLKALYVN GSQVAGIQNR TFASLASLQL LQLADNRLQV LHGYEFEQLS
     SLRELYLQNN QLTTIENATL APLVSLEVLR IDGNRLVTLP IWQMHATHFG KRLRSISLGR
     NQWSCRCQFL QALTSYVSDN AIIVQDAQDI YCMAASNSAN YDVDAYDANG SQGTLQKREL
     DFNSTGAACT DYYSGGSMLQ HGIPESYIPL LAAALALVFL LVVIIIVFVF RESLRIWLFA
     HYGVRVFGPR CEESEKLYDA VLLHSAKDSE FVCQHLASEL ETGRPPLRVC LQHRDLAHDA
     THYQLLEATR VSRRVVILLT RNFLQTEWAR CELRRSVHDA LRGRPQKLVI IEEPEVAFEA
     ESDIELLPYL KTSAVHRIRR TDRHFWEKLR YALPVDYPTY RGNNYTLDHN HERIKQPASP
     GLLYRQAPPP AYCGPAEGGP AAAAAAAAAV EQNYSTATTA TPSPRPQRRG DHQGGGGSGS
     SSHGHHLHAQ YYQHHGMRPP SEHIYSSIDS DYSTLDNEQH MLMMPNGPPS MEGQRAQTWR
     PKQQQQQQQP PNAMGHAGTL GPSSNLAKAT SQQQQQQQQQ QQQQPTGSGQ QQGPHVQAYL
     V
//
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