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Database: UniProt
Entry: B4N201_DROWI
LinkDB: B4N201_DROWI
Original site: B4N201_DROWI 
ID   B4N201_DROWI            Unreviewed;      1629 AA.
AC   B4N201;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 2.
DT   16-OCT-2019, entry version 62.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDW78390.2};
GN   Name=Dwil\GK16205 {ECO:0000313|EMBL:EDW78390.2};
GN   ORFNames=Dwil_GK16205 {ECO:0000313|EMBL:EDW78390.2};
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260 {ECO:0000313|EMBL:EDW78390.2, ECO:0000313|Proteomes:UP000007798};
RN   [1] {ECO:0000313|EMBL:EDW78390.2, ECO:0000313|Proteomes:UP000007798}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24 {ECO:0000313|Proteomes:UP000007798};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
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DR   EMBL; CH963925; EDW78390.2; -; Genomic_DNA.
DR   RefSeq; XP_002067404.2; XM_002067368.2.
DR   SMR; B4N201; -.
DR   EnsemblMetazoa; FBtr0421840; FBpp0379930; FBgn0218207.
DR   eggNOG; KOG4271; Eukaryota.
DR   eggNOG; ENOG410XR4E; LUCA.
DR   InParanoid; B4N201; -.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.10.440; -; 2.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR002713; FF_domain.
DR   InterPro; IPR036517; FF_domain_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039007; pG1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR032835; RhoGAP-FF1.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR039006; RhoGAP_pG2.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF00071; Ras; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF16512; RhoGAP-FF1; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51676; FF; 4.
DR   PROSITE; PS51852; PG1; 1.
DR   PROSITE; PS51853; PG2; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007798};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007798}.
FT   DOMAIN      252    320       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      365    419       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      426    480       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      482    547       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      591    764       PG1 pseudoGTPase. {ECO:0000259|PROSITE:
FT                                PS51852}.
FT   DOMAIN      765    925       PG2 pseudoGTPase. {ECO:0000259|PROSITE:
FT                                PS51853}.
FT   DOMAIN     1416   1620       Rho-GAP. {ECO:0000259|PROSITE:PS50238}.
FT   COILED     1370   1408       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1629 AA;  186154 MW;  5BCB161D0B59B83D CRC64;
     MRQFNISVIG LSGTEKDRGQ VGVGKSCLCN RFMRPMADDY FIDHISVLSQ SDFSGRIVNN
     DHFLYWGEVR KTTEEGVEYN FNIIEQTEFM DDSTFQAFKV GKMDPYLKRC TSTKVFSAEK
     LMYICKNQLG IEKEYEQKVM PDGRLSIDGF VVVFDVSPVP NRSVEKQVEF VQNVIATIIK
     NKKPLVLVTT KNDDAYELYV REAEKISQRK DYKSTVQLIE TSAHESINID LAFLMLAQMI
     DKVKNRVKII SYQESAKSRK ELLDTRSEAV TRLIRNQITD YHILWSQGSK MLSQYREWNE
     FLNIFGNEAG QKLFRRHMKK LRDDHLNKKL HQYLDKFALA LEYMLPDISA LNISDDDAWE
     CARNYLQNHI EFEQYFFECP QASWTELIDM DEAEDETRIP FDVLETSESE TVFRNYLNSV
     QQDKKKIGWK QQFKMLLEES GFVTPGKQLS EVRVLFMGRE CFEALSEHDC QQIYDIHQDE
     IIEKSKQNFV ELLLEHAQYF LQFKNVDIIT QEDVRQITDV IQEDSRYKML DRLDQERRVI
     LLQHLRFIHC PIREHCPFFN NCVDSLIEEV LSDKSASNHK SQGGGWKTTG NGSDRTLNLL
     IVGSEHLASD LLNDIRICTG SKGEYIYENQ TYYLNYRIAN GDMEAFKAID VSSSGLICVY
     SNQQSFETLK DNLERTLLCN LELEDKFENL PIVLVYQPQD LKENEVEYLR SEGMRLSEML
     HCDFIDHTQN HQKYVYDILN IVILSLKLTE MKSYEPYPSN HTDLRILCCI FCGDQYDIEN
     IVQPLVAESM MVKANEHSII IDVFIGDAKR RVEFILSSYH GTNQYRDELI HGYIYFYSAK
     RRSSLANLSI LAAQNANIPL QIIAVTESGG VNAFFNSDIC QFLITEGNAL ADRFKGSFMT
     FSADQYVKFA FYNPFLKTAW DNKYEVENLH VEESITLDSG EGTLENSVNQ MPRPPPRHES
     YMLSNTLGTD GSGSENYEML PTRSLNSLNE ERDISLDEIY DDNNEKPKHL HQRFQIFPPP
     TTPPEPAPPD HQLITCTYKS QFVSASESSL EEITSDVSGS KDSLATHDAE WLEDKSDARR
     NMNKNSIWNN FSGSATNTHA YTTGRRHIDS NLNRIRPKGP SQTLKVGEAP SRNCPAMSSS
     TFTLPTQQPG KLNMKNFQLV SDAVAKMNFT GSGSGSMAES YLGGCDVGGV TAGVGVGGGP
     IPIDKDAKRY DHAQLDGEDE DSEELAEYEQ IYENEDCTES DSCASSTERR VRQQNAYYKA
     NKKAATTKKN KKKKVAIPVQ TPRVPPFGSY VSPPEIPLHY QRMAGAGGVG VNVIGGPIGA
     EKSEAGVSEF MKSDKSPEYS MVPELANAGI FGAENLPEFN MNAKCLKDFE KLEKRRIKEE
     TARLRKLQEK EKEQEKKLKR KLKQQNAKGI TETTEAQFGK LMICSEKDDN IPIFLIKCVE
     FIEKEGLDSE GIYRVPGSRA HVDMLFQRFE EDPNTVIDVL DIPVNAVATA LKDFFSKRLP
     PLFSKDIIKE LEEIAGSRGV GSSKLNVEVK TDRSCRLIAL KSLLQKLPPI NFAILKYIFQ
     HFVHVSDNSK LNSMDSKNLA ICWWPTLIPI DFTDMGHFEQ LRPYLEDIVQ TMIDQFPYLF
     CGKDAFVMV
//
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