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Database: UniProt
Entry: B4N2Z1_DROWI
LinkDB: B4N2Z1_DROWI
Original site: B4N2Z1_DROWI 
ID   B4N2Z1_DROWI            Unreviewed;      1050 AA.
AC   B4N2Z1;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 2.
DT   20-JUN-2018, entry version 59.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDW78730.2};
GN   Name=Dwil\GK12546 {ECO:0000313|EMBL:EDW78730.2};
GN   ORFNames=Dwil_GK12546 {ECO:0000313|EMBL:EDW78730.2}, GK12546
GN   {ECO:0000313|FlyBase:FBgn0214556};
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260 {ECO:0000313|EMBL:EDW78730.2, ECO:0000313|Proteomes:UP000007798};
RN   [1] {ECO:0000313|EMBL:EDW78730.2, ECO:0000313|Proteomes:UP000007798}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24 {ECO:0000313|Proteomes:UP000007798};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
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DR   EMBL; CH964062; EDW78730.2; -; Genomic_DNA.
DR   RefSeq; XP_002067744.2; XM_002067708.2.
DR   STRING; 7260.FBpp0241689; -.
DR   EnsemblMetazoa; FBtr0418820; FBpp0376962; FBgn0214556.
DR   KEGG; dwi:Dwil_GK12546; -.
DR   FlyBase; FBgn0214556; Dwil\GK12546.
DR   eggNOG; KOG3703; Eukaryota.
DR   eggNOG; ENOG410XQN4; LUCA.
DR   InParanoid; B4N2Z1; -.
DR   KO; K02577; -.
DR   OrthoDB; EOG091G02CP; -.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblMetazoa.
DR   GO; GO:0000137; C:Golgi cis cisterna; IEA:EnsemblMetazoa.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0015016; F:[heparan sulfate]-glucosamine N-sulfotransferase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   GO; GO:0007427; P:epithelial cell migration, open tracheal system; IEA:EnsemblMetazoa.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:EnsemblMetazoa.
DR   GO; GO:0006024; P:glycosaminoglycan biosynthetic process; IEA:EnsemblMetazoa.
DR   GO; GO:0015014; P:heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; IEA:EnsemblMetazoa.
DR   GO; GO:0008587; P:imaginal disc-derived wing margin morphogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0007474; P:imaginal disc-derived wing vein specification; IEA:EnsemblMetazoa.
DR   GO; GO:0048312; P:intracellular distribution of mitochondria; IEA:EnsemblMetazoa.
DR   GO; GO:0007509; P:mesoderm migration involved in gastrulation; IEA:EnsemblMetazoa.
DR   GO; GO:0045570; P:regulation of imaginal disc growth; IEA:EnsemblMetazoa.
DR   GO; GO:0007367; P:segment polarity determination; IEA:EnsemblMetazoa.
DR   GO; GO:0007283; P:spermatogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0006790; P:sulfur compound metabolic process; IEA:EnsemblMetazoa.
DR   GO; GO:0048488; P:synaptic vesicle endocytosis; IEA:EnsemblMetazoa.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:EnsemblMetazoa.
DR   InterPro; IPR021930; Heparan_SO4_deacetylase.
DR   InterPro; IPR037359; NST/OST.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000863; Sulfotransferase_dom.
DR   PANTHER; PTHR10605; PTHR10605; 1.
DR   Pfam; PF12062; HSNSD; 1.
DR   Pfam; PF00685; Sulfotransfer_1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007798};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007798};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    164    182       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      171    663       HSNSD. {ECO:0000259|Pfam:PF12062}.
FT   DOMAIN      753   1020       Sulfotransfer_1. {ECO:0000259|Pfam:
FT                                PF00685}.
SQ   SEQUENCE   1050 AA;  118530 MW;  CB1F277C51FB5268 CRC64;
     MTISLAATAA ANNANRYEKL IRQPNMATVT SGTGTQTNME AEAAIHHHLQ QHGQTTTFTD
     RTILLPAMLH GGNGDSLSNS TNIVTYKAKA NGSCSSLSTS SSSPSSPASF ASCSSTSSSS
     PIASGSSSHL VGGAVGGGGL PGGWFCHCCN LIARRCFGIN VRRCVLALFA ITVVSIFYYT
     HYVDTGVFVG LIQRDTHPAP IINCRLINSA GNHIRREASP APDHRSEARL RIDPKVLVFV
     ETTYSGLGRD IAELLVYNRI KYKIEVAGKS LPVLTNLDKG RYGVIVFENL DKYLNMDKWN
     RELLDKYCRE YSVGIVGFVS PSEETLVGAQ LRDFPLYVNT NLRLRDASLN PESSVLRLTR
     AGETAWGVLP GDDWAVFQHN HTTYEPVEWA QRNTQEYPAD MDVGGQVQLP LSTVVQDRGH
     FDGIQRVLFG SSLRFWLHRL LFLDALSYLS HGHLSLNLER MILVDIDDIF VGEKGTRLRP
     DDVRALIATQ KNIGAMVPGF RFNLGFSGKY YHHGTREENL GDDFLLQNVE EFNWFSHMWK
     HQQPHLYDNL TLLMAEMQMN HAFAKEHNIP TDSGYSISPH HSGVYPAHEL LYMAWKKVWQ
     VKVTSTEEYP HLRPARLRRG FIHRNIMVLP RQTCGLFTHT MYIDRYPGGR DKLDESIQGG
     ELFQTIVYNP INIFMTHMSN YGSDRLALYT FQSVIKFLQC WTNLKLASAP PIQLAEMYFQ
     LHPEEVDPVW GNPCDDARHK KIWSKTKNCE SLPKFLVIGP QKTGTTALYT FLAMHGSIAS
     NIPSPDTFEE VQFFNGNNYY RGLDWYMDFF PSESLPNLTS ISSSSSSMPP TATQSSSRYM
     FEKSATYFDG EAVPKRAHTL LPHAKIVTIL ISPAKRAYSW YQHQKAHGDV IANNYSFYQV
     ITASDSAPKA LKDLRNRCLN PGKYAQHLEH WLAYYPAQQM HIIDGEQLRL NPIDVMNELQ
     RFLKIQPLLD YSNHLRYDVK KGFYCQAVSE KRTKCLGKSK GRQYPTMDER SAKLLQRYFL
     NHNTALVKLL KKLGSRPIPQ WLKDDLSTGT
//
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