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Database: UniProt
Entry: B4N3A9_DROWI
LinkDB: B4N3A9_DROWI
Original site: B4N3A9_DROWI 
ID   B4N3A9_DROWI            Unreviewed;      2119 AA.
AC   B4N3A9;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 2.
DT   05-JUN-2019, entry version 71.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDW78848.2};
GN   Name=Dwil\GK12671 {ECO:0000313|EMBL:EDW78848.2};
GN   ORFNames=Dwil_GK12671 {ECO:0000313|EMBL:EDW78848.2};
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260 {ECO:0000313|EMBL:EDW78848.2, ECO:0000313|Proteomes:UP000007798};
RN   [1] {ECO:0000313|EMBL:EDW78848.2, ECO:0000313|Proteomes:UP000007798}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24 {ECO:0000313|Proteomes:UP000007798};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- COFACTOR:
CC       Name=[3Fe-4S] cluster; Xref=ChEBI:CHEBI:21137;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000187-2};
CC       Note=Binds 1 [3Fe-4S] cluster. {ECO:0000256|PIRSR:PIRSR000187-2};
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DR   EMBL; CH964062; EDW78848.2; -; Genomic_DNA.
DR   RefSeq; XP_002067862.2; XM_002067826.2.
DR   STRING; 7260.FBpp0241814; -.
DR   EnsemblMetazoa; FBtr0417410; FBpp0375575; FBgn0214680.
DR   GeneID; 6645095; -.
DR   KEGG; dwi:6645095; -.
DR   eggNOG; KOG0399; Eukaryota.
DR   eggNOG; COG0067; LUCA.
DR   eggNOG; COG0069; LUCA.
DR   eggNOG; COG0070; LUCA.
DR   eggNOG; COG0493; LUCA.
DR   InParanoid; B4N3A9; -.
DR   KO; K00264; -.
DR   OrthoDB; 126283at2759; -.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   GO; GO:0051538; F:3 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   GO; GO:0016040; F:glutamate synthase (NADH) activity; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0006537; P:glutamate biosynthetic process; IEA:InterPro.
DR   CDD; cd00982; gltB_C; 1.
DR   CDD; cd02808; GltS_FMN; 1.
DR   Gene3D; 1.10.1060.10; -; 1.
DR   Gene3D; 2.160.20.60; -; 1.
DR   Gene3D; 3.20.20.70; -; 2.
DR   Gene3D; 3.50.50.60; -; 2.
DR   Gene3D; 3.60.20.10; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR028261; DPD_II.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   InterPro; IPR017932; GATase_2_dom.
DR   InterPro; IPR002489; Glu_synth_asu_C.
DR   InterPro; IPR036485; Glu_synth_asu_C_sf.
DR   InterPro; IPR006982; Glu_synth_centr_N.
DR   InterPro; IPR012220; Glu_synth_euk.
DR   InterPro; IPR002932; Glu_synthdom.
DR   InterPro; IPR006005; Glut_synth_ssu1.
DR   InterPro; IPR009051; Helical_ferredxn.
DR   InterPro; IPR029055; Ntn_hydrolases_N.
DR   Pfam; PF14691; Fer4_20; 1.
DR   Pfam; PF00310; GATase_2; 1.
DR   Pfam; PF04898; Glu_syn_central; 1.
DR   Pfam; PF01645; Glu_synthase; 1.
DR   Pfam; PF01493; GXGXG; 1.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   PIRSF; PIRSF000187; GOGAT; 1.
DR   SUPFAM; SSF46548; SSF46548; 1.
DR   SUPFAM; SSF56235; SSF56235; 1.
DR   SUPFAM; SSF69336; SSF69336; 1.
DR   TIGRFAMs; TIGR01317; GOGAT_sm_gam; 1.
DR   PROSITE; PS51278; GATASE_TYPE_2; 1.
PE   4: Predicted;
KW   3Fe-4S {ECO:0000256|PIRSR:PIRSR000187-2};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007798};
KW   Iron {ECO:0000256|PIRSR:PIRSR000187-2};
KW   Iron-sulfur {ECO:0000256|PIRSR:PIRSR000187-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000187-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007798}.
FT   DOMAIN       93    486       Glutamine amidotransferase type-2.
FT                                {ECO:0000259|PROSITE:PS51278}.
FT   REGION       21     48       Disordered. {ECO:0000256|MobiDB-lite:
FT                                B4N3A9}.
FT   REGION      982   1007       Disordered. {ECO:0000256|MobiDB-lite:
FT                                B4N3A9}.
FT   ACT_SITE     93     93       For GATase activity. {ECO:0000256|PIRSR:
FT                                PIRSR000187-1}.
FT   METAL      1207   1207       Iron-sulfur (3Fe-4S). {ECO:0000256|PIRSR:
FT                                PIRSR000187-2}.
FT   METAL      1213   1213       Iron-sulfur (3Fe-4S). {ECO:0000256|PIRSR:
FT                                PIRSR000187-2}.
FT   METAL      1218   1218       Iron-sulfur (3Fe-4S). {ECO:0000256|PIRSR:
FT                                PIRSR000187-2}.
SQ   SEQUENCE   2119 AA;  233044 MW;  4D60752FD71B0FED CRC64;
     MAPINTDNCE FECATVDTSV SNNFESNTNN ISNSSSSTSS SSNNNIINNN EESNEVHLSD
     NDQHQDDDVQ EQMPWEAPGK QGLYDPQNEH EACGVGFIVA IDGKRSHKIL RDAQTLSERM
     NHRGACACDN DTGDGAGVLA SIPHGLYAKA LASQGVTLPE LGNYATGIFY LDEAQHSAAE
     TEFNALAKSL GLDVITWRTV PAKQEAIGVV ARKSEPLSRQ VFVRRPEGSD EKTFERQVFV
     LRKRASHELT KPGRRFYICS LSDRTVVYKG LFTSDQLWDY YTDLKNPEFE TYLALVHTRF
     STNTFPSWER AHPLRVLAHN GEINTLRGNV NLMKAREGVM QSELFGDQLK KLYPVVEPNL
     SDSGSFDCVL EFITMASERS LPESVMTMVP EAWQNDKTMP QEKRDFYQWA ACVMEPWDGP
     ALISFTDGRF IGAVLDRNGL RPSRFYVTKD NVLVMASEVG VYDVDPSQVS LKSRLKPGRM
     LLVDTKEKKL IQDIELKSQI AKSRPHSEWL QQKMITLDEI RNANVLNAPV EEQPKLPASQ
     RGIFDPRLPL FGYTTETVNM LLIPMFKNKK EALGSMGNDA PLACLSAFQP IPYEYFKQLF
     AQVTNPPIDP FREKVVMSMQ CPIGPEANLL EPSAQQVHRI WLPNPILSIP DTQLLKRNTH
     RGWKTKVLDI TFQFNDGVQG YLDCIDRVCR EGANAAQAGY QILVISDREA GAKGRLAVSA
     LLALGALHHH LIETLQRMKV GIVVETAEAR EVHHICVLLG YGADAICPYL AFELAQALRD
     DGVIGPEVTN KQIYNAYAQA IDTGIAKVMA KMGISTLQSY KSAQIFEAVG LGNDLVNKCF
     RGTQSRIGGV TLEIMAKEGL DRYQLTYCKV SPDTRILRNP GQYHWRHGGE AHINEPSSIG
     SLQEAAVNKN LGAFEQFKKT TLDSVKKCAL RGQLEFVTDR QKIDISEVEP ASEIVKRFAT
     GAMSFGSISL EAHQTLSITM NRIGGKSNTG EGGEDSDRYL NQDPNNSRRS AIKQVASGRF
     GVTASYLANA DDLQIKMAQG AKPGEGGELP GYKVTKDIAK TRKSVPGVGL ISPPPHHDIY
     SIEDLAELIY DLKCSNPNAR ISVKLVSEVG VGVVASGVAK GKAEHIVISG HDGGTGASSW
     TGIKNAGLPW ELGVAETHQV LVLNNLRSRV VVQADGQLRT GFDVVVAALL GADEFGFSTA
     PLIVMGCTMM RKCHLNTCPV GIATQDPVLR KKFTGKPEHV INFFFMLAED IRQIMANLGI
     RKFQDLIGRT DLLRVASQRE SKASHLDLKL LLQPALDLRP GTNIVGGSIK QDFQLEKRSD
     NELIIKAQQI FNGSADNVTV KMRIHNEERA FGSTLSYHIA CKYGEAGLPL DKSIDIFLEG
     SAGQSFCAFL ARGVNVTLKG DANDYVGKGL CGGNVVITPP DTATFESHLN VIAGNVCLYG
     ATEGTAYFRG IAAERFCVRN SGVTAVVEGV GDHGCEYMTG GLVLILGLTG RNFAAGMSGG
     IAYVYDIDGT FKPKVNPESV ELLPLELSED VALVKKLLVD FIEKTGSKVA KQLLDNWAEA
     QTKFVKVFPY EYQKALKDLA EQEAVEQPLK TPALENGNGK HEPHIKDIEE AIQDVALEQK
     RADRVLDKTR GFVKYKRETA PYRDAAERQQ DWNEVYNFPH VRKNLKVQAA RCMECGVPFC
     QSNSTGCPLG NIIPKWNDLV FHGEWQEALR QLLQTNNFPE FTGRVCPAPC EGSCVLGISE
     PAVTIKNIEC AIIDHAFEQG WIKAEIPEVR TGKRVAIVGS GPSGLAASQQ LNRAGHFVTV
     FERNDRVGGL LQYGIPTMKL SKEVVKRRVD LMADEGIEFR TNVHVGKDLK AEQLLQEYDA
     VLLTTGSTWP RDLPLANRDL KGIHFAMEFL EAQQKKQLGG KQDIISAAGK DVIIIGGGDT
     GCDCIATSLR QGAKSITSFE ILPEPPQKRA EDNPWPQWPK VFRVDYGHEE VKLNTGKDPR
     QYCTTTKEFV GENGHIKGVN TVQVEWTKTE TGQWRMQEVA GSEKYFAADL ILLAMGFLGP
     EKTVPGELGL ELDPRGNIKA CNGQYGTSNA KVFAAGDCRR GQSLVVWAIT EGRQAARQVD
     SYLTGKSSGL PGPGGVIRT
//
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