ID B4N680_DROWI Unreviewed; 2675 AA.
AC B4N680;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=CAP-Gly domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=Dwil\GK17791 {ECO:0000313|EMBL:EDW79869.2};
GN ORFNames=Dwil_GK17791 {ECO:0000313|EMBL:EDW79869.2};
OS Drosophila willistoni (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7260 {ECO:0000313|EMBL:EDW79869.2, ECO:0000313|Proteomes:UP000007798};
RN [1] {ECO:0000313|EMBL:EDW79869.2, ECO:0000313|Proteomes:UP000007798}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14030-0811.24 {ECO:0000313|Proteomes:UP000007798};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
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DR EMBL; CH964154; EDW79869.2; -; Genomic_DNA.
DR RefSeq; XP_002068883.2; XM_002068847.2.
DR SMR; B4N680; -.
DR STRING; 7260.B4N680; -.
DR EnsemblMetazoa; FBtr0419552; FBpp0377681; FBgn0219790.
DR eggNOG; KOG4225; Eukaryota.
DR HOGENOM; CLU_000247_0_0_1; -.
DR InParanoid; B4N680; -.
DR Proteomes; UP000007798; Unassembled WGS sequence.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd11781; SH3_Sorbs_1; 1.
DR CDD; cd11782; SH3_Sorbs_2; 1.
DR CDD; cd11780; SH3_Sorbs_3; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR003127; SoHo_dom.
DR PANTHER; PTHR14167:SF114; CAP, ISOFORM AC; 1.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF14604; SH3_9; 2.
DR SMART; SM00326; SH3; 3.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50002; SH3; 3.
DR PROSITE; PS50831; SOHO; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Reference proteome {ECO:0000313|Proteomes:UP000007798};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 778..841
FT /note="SoHo"
FT /evidence="ECO:0000259|PROSITE:PS50831"
FT DOMAIN 2417..2476
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 2486..2545
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 2616..2675
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 579..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 638..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 713..733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 901..933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1025..1163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1282..1308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1329..1357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1372..1416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1491..1570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2221..2314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 462..489
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1687..1721
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2342..2369
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..445
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..611
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..664
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 901..918
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1044..1065
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1066..1101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1110..1163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1340..1357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1399..1416
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1501..1539
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2242..2259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2261..2287
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2675 AA; 304280 MW; 7BA8EBDC76B34771 CRC64;
MSSTTTSSTT ATTNDGHNGI SNKFPSSMES ELARMFPSLQ QQGDIFAEQR KRFSNIESES
KNFPELKLNQ NQSKRYSNIE TKSYESKKRT ENGQVIYDIT NSSHEKQVEG DKDLSKADDE
VRPPPIPPPP MMSETKLNGN TQANTFIKDD VFIKNSQTKD ESKNAASTYE EFRQRAKAAV
DAIGQGQSGP GLDTDNVFKD FDRLSQQLNQ ELQSTREHRQ KSASLYDLSG LTRQTSCQSQ
QQLNQLKQQR HAHMQELEKE IERSAKSRME RMSSVEPKTY QIPIEMEANN RSRRSESLCN
LNEVPRRPHT SAGVYKEEDD WSRYASDLGY SENIARPFAR EVEICYQRQR PNHGGIRAPR
LLSASSNDLS SFTSYDSFNA YGGRRTHAPM LSEAPQQQQQ RPQYASCYSL IERNPNPTYI
STTSRRGTSP APPQVAPPPP PPAYDRQQRR SSLPRELHEQ QLKYILSKEE ELKLEVERLQ
HERRRLMEEM QRAPVINPSQ RRESYRPTPK LPTLSEDEVF RQQMAEEWMN KVAERDERRH
QKIIKISKIE DEPEHLTTEQ ANISDEFLNR VKERRHKLAM PADSDWESGA ESQPQGKAGQ
SGPESEPETS VHILEGQTEA NLRQLPRHLR EFAKFSTQEQ LPDGGQMEHH EQQEKREDFT
DNSHSSATKK SSIIKTYKVS RLPPSVQAHL PATTMNVKMR PRPQKQTRFL LNQQSNHHHH
HQQQQQKRRS WSESDLLKEI DNELQLAKGF LYANVYQVKH EYMSEPETEY DRPRKMAQLG
RRQYEGIGPV TNDGMPIILR SEVQEPHQHE WYKRLYQTIH KQKNGDDFVI RYKCPRARPS
YKSNGYVSEP EPNYDSDYST VRYRTQNPHR VQSVSSAVNV RNLNQDEKLY GTMPNPIKSA
QNSYKNQPGR IENYTTGHSS VSEKEKKENL EQSKLSPLYT EGNLSRALAK ESGYTSDSNL
VFRKKELSFG SPLSPVEQKQ AYKSLQAGGE PPLLGFRKPA PEKPKEIVEE FEFIQITPTL
TKIRVSTKEL KEESEEEEEE PVVPKPQPPP PPPPPPPPPL PPPQSSAATG KNQDKMFSNF
SKNLPSFIPL SKKQQQQQLD QPSNPPAPPS RKSSCTKSTV RVSTKSRHEQ CFQPPGGNGS
TITLRKVTSS SSSRREPICR SKSTGAVSTL LATLTATKET RNKDGCLTRV QHQHSRLRSV
SPSRRRPPAR ILLALRQSSR SPVAFGRSIS KERSFAEEKK RLENTLPANR TNFEASTNIL
RDPLLKSPQD VREAVRSYAT CKAQHTRSKS LPRLPRQTNS TVSTTTRHTM CFPQVRPQNL
LDCTRALKKT PKKGKNQPKR ASNDSLPRSN STYSIDSMVR EEEIISIAPP KTYVSKPKTS
PAPKCLMGPV PLQNSRSEGH VPRKQRQLAK KQPLSDTVRE KTNFWNDYNA KQAMSLPQQS
TSATSEYKFC SLEPEDVYDC VLPPNSGCIE DLVWKYENKN VGESQIKGIT DIARPVSPHP
DYETKSLDRR RFSPTREVRV PQREVRSPSR RRIDSLRSKE QVIARASSLS SADDRAKRGA
GAGSAAPTNG TIYQCGDLAH SATSLNQHLE RHSPSCRYRN NCERFTELNR FYSTLERVGQ
LERATSSSNF HPLRKDAELL DFDEWRKVRL HERAEKELQY LVGKLQMDQR ERDLHFRSKD
INDLKWRHEA DQALSAKKKS VEDLRENFEK WQILRQKQQQ QLEVEQPQQR QWRRNTVADL
ATTLEHESTV GSSSTPATTE RHLNNELVST LSKDQIKKIT QQLNEIYAGG NRGQKPAIDE
QYIVTVEKTS NQNQPPNTLK VRCNSSITKE QLLEPVLRKR DEQQPRATRS QSPVVIARET
RGAIAAKNAE LTLTKGAPDV PPRPKPIASS TVIPLTKVEQ AESREASENI NEKIQYFEER
QYDEPPKTIY HAREDSSPDE AEVMRLIEQN MQARRQQNQI QSHVELSNSL TDLSGIYGER
PAARVNFHLH SPPVRPPDDG EHELVSFENG SVEDPHHQSG SIELYDSYYR SRSLSPQSQV
SACSSSSYLQ RVYTGEVQKI KEKFESIQSE KLTNDFFGLS SLRKARSDPE FNAGSKDALA
SATETEPQRK TIIKQISHSP SPTLDASRGR RRQRASRLMP HIDIISKTAA LKKELPPPPP
KVVSPTRSLS SNSNYIERLK SRYESTSEAA TLHYLSTSHP DLRDVHESIS PHLSANWVAH
KHPHPERLAP PQPKKPQRLT PAATRAKSTS PPRPAKSSLH QQKKSLRDDI FANQKFDPQK
HRPKARYVPD GAPASAPAPA LAPKPATTPL RGSGVGTLER LKKAGMAVTF KDVNIHFKTP
VRHEYKQNIS EEELAIRQAE HMQKLYQEER RRKYLQELQD MNSRRHTDNF TPSQKSPIAL
NRYDDFPTDV TLKSLVGPKT VAKALYNFQG QTSKELSFRK GDTIYIRRQI DANWFEGEHN
AMIGLLPASY VEIVSRDGAR TPAKRPSEGQ ARAKYNFQAQ SGIELSLNKG ELVTLTRRVD
GNWFEGKIAN RKGIFPVSYV EILTDIGAED IAARTTTTVI NSQSTTNLRP NLDVLRTNIN
NEFNTITQNG AQPPNGILKD TRGLHKTDAL HVDTTSEPVA YRALYKYRPQ NSDELELLEG
DLVHVLEKCD DGWFVGTSQR TGCFGTFPGN YVERA
//
