GenomeNet

Database: UniProt
Entry: B4NDE5
LinkDB: B4NDE5
Original site: B4NDE5 
ID   UBA5_DROWI              Reviewed;         406 AA.
AC   B4NDE5;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   13-FEB-2019, entry version 54.
DE   RecName: Full=Ubiquitin-like modifier-activating enzyme 5;
DE            Short=Ubiquitin-activating enzyme 5;
GN   ORFNames=GK10218;
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: E1-like enzyme which activates UFM1. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family. UBA5
CC       subfamily. {ECO:0000305}.
DR   EMBL; CH964239; EDW82851.1; -; Genomic_DNA.
DR   RefSeq; XP_002071865.1; XM_002071829.2.
DR   SMR; B4NDE5; -.
DR   STRING; 7260.FBpp0239361; -.
DR   PRIDE; B4NDE5; -.
DR   EnsemblMetazoa; FBtr0240869; FBpp0239361; FBgn0212233.
DR   GeneID; 6648687; -.
DR   KEGG; dwi:6648687; -.
DR   FlyBase; FBgn0212233; Dwil\GK10218.
DR   eggNOG; KOG2336; Eukaryota.
DR   eggNOG; COG0476; LUCA.
DR   InParanoid; B4NDE5; -.
DR   KO; K12164; -.
DR   OMA; ETHNYNI; -.
DR   OrthoDB; 1092362at2759; -.
DR   PhylomeDB; B4NDE5; -.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   GO; GO:0019008; C:molybdopterin synthase complex; IEA:EnsemblMetazoa.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR   GO; GO:0050905; P:neuromuscular process; IEA:EnsemblMetazoa.
DR   InterPro; IPR029752; D-isomer_DH_CS1.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   Pfam; PF00899; ThiF; 1.
DR   SUPFAM; SSF69572; SSF69572; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding;
KW   Reference proteome; Ubl conjugation pathway; Zinc.
FT   CHAIN         1    406       Ubiquitin-like modifier-activating enzyme
FT                                5.
FT                                /FTId=PRO_0000391951.
FT   ACT_SITE    249    249       Glycyl thioester intermediate.
FT                                {ECO:0000250}.
FT   METAL       225    225       Zinc. {ECO:0000250}.
FT   METAL       228    228       Zinc. {ECO:0000250}.
FT   METAL       302    302       Zinc. {ECO:0000250}.
FT   METAL       307    307       Zinc. {ECO:0000250}.
FT   BINDING      82     82       ATP; via amide nitrogen. {ECO:0000250}.
FT   BINDING     103    103       ATP. {ECO:0000250}.
FT   BINDING     126    126       ATP. {ECO:0000250}.
FT   BINDING     149    149       ATP. {ECO:0000250}.
FT   BINDING     183    183       ATP. {ECO:0000250}.
SQ   SEQUENCE   406 AA;  44758 MW;  59E20F3190505818 CRC64;
     MSAIDELQAL IVELKSELEA QKTETRQQQA QAQQARQRID RMSAEVVDSN PYSRLMALQR
     MNIVKDYERI REKTVAVVGV GGVGSVTADM LTRCGIGKLI LFDYDKVELA NMNRLFFTPD
     QAGLSKVEAA ARTLTFINPD VKIETHNYNI TTVDNFDNFL TTISQSGTEP GTPVDLILSC
     VDNFEARMAI NAACNEHSLN WFESGVSENA VSGHIQFIRP GDTACFACAP PLVVAENIDE
     RTLKREGVCA ASLPTTMGIT AGFLVQNALK YLLNFGEVSD YLGYNALNDF FPKMTLKPNP
     QCDDRHCLLR QKEFQTKPKP VKKEVEIVAE EPLHATNEWG IELVAEDAPA TEDADEPKPI
     VSDIGEGLRL AYEAPSKSTE TTSEATTTTT GDETSLDDLM AQMKSM
//
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