ID PESC_DROYA Reviewed; 628 AA.
AC B4NY70;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028};
GN ORFNames=GE10391;
OS Drosophila yakuba (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tai18E2 / Tucson 14021-0261.01;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03028}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03028}.
CC -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000255|HAMAP-
CC Rule:MF_03028}.
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DR EMBL; CM000157; EDW88672.1; -; Genomic_DNA.
DR RefSeq; XP_002088960.1; XM_002088924.2.
DR AlphaFoldDB; B4NY70; -.
DR SMR; B4NY70; -.
DR EnsemblMetazoa; FBtr0256909; FBpp0255401; FBgn0228257.
DR GeneID; 6527888; -.
DR KEGG; dya:Dyak_GE10391; -.
DR eggNOG; KOG2481; Eukaryota.
DR HOGENOM; CLU_019619_0_0_1; -.
DR OMA; QKVTWIV; -.
DR OrthoDB; 169151at2759; -.
DR PhylomeDB; B4NY70; -.
DR Proteomes; UP000002282; Chromosome 2L.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR CDD; cd17709; BRCT_pescadillo_like; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR HAMAP; MF_03028; Pescadillo; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR010613; PES.
DR PANTHER; PTHR12221; PESCADILLO - RELATED; 1.
DR PANTHER; PTHR12221:SF6; PESCADILLO HOMOLOG; 1.
DR Pfam; PF16589; BRCT_2; 1.
DR Pfam; PF06732; Pescadillo_N; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 3: Inferred from homology;
KW Coiled coil; Nucleus; Phosphoprotein; Ribosome biogenesis; rRNA processing.
FT CHAIN 1..628
FT /note="Pescadillo homolog"
FT /id="PRO_0000370463"
FT DOMAIN 321..414
FT /note="BRCT"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT REGION 438..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 593..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 590..626
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT COMPBIAS 453..470
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..521
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 522..538
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..563
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..618
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 453
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 457
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 628 AA; 74029 MW; 96167BA2D1EA52DA CRC64;
MRRPKKYESG EATQYISRRA ALRKLQLSLN DFRRLCILKG VYPREPKHRR RAQKGSSEIK
VLYHTKDIRF LLHESIVWTL RDYKIFAKKS NRDRAIKDFR NLKRRLALFP EIKLDHIVKE
RYPTFIDALK DLDDCLTLLF LFSTFPSLHL IPREQSNLCR RLTIEFLHYV IASKSLRKVF
ISIKGYYFQA EIKGQKVTWI VPHYYPFKPQ SRQEVDFKVM SIFVEFYTIM LGFTNFRLFH
GLNLAYPPQF PSSVLQDSEE SLKDEASFVS DRIAALNFEL LRTDKVQEDE EELDIDMELL
EQDGDSKRII KMKQEAQEVS RLRTLFKGLK FFINREVPRE PLVILIRSFG GKVSWDSSIF
AGSTYDEADE TITHQIVDRP SISTQYISRD YIQPQWVFDC VNQRQLLPTN KYFIGETLPP
HLSPFVDSKR DSYIPPEEKA LLDPSLIETH AQSDDDSEDE AEKEEEEAVD QELLDAQLQL
AYQQETAEYK KYGGPDGVNE DEEDPEDDDE DDDEEEEEEE LDEKTKRLQE EKQKMSVQSG
KVHKVNKRQL HKAEVDEHRL QARMVKPRHR NLFRKLIREK QTKEKEEWLL RKKRRTHEAN
EKEARKTAKR EARKEAAAAA AKASKLGK
//
