ID SCC4_DROYA Reviewed; 632 AA.
AC B4PS83;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 67.
DE RecName: Full=MAU2 chromatid cohesion factor homolog;
DE AltName: Full=Cohesin loading complex subunit SCC4 homolog;
GN ORFNames=GE24275;
OS Drosophila yakuba (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tai18E2 / Tucson 14021-0261.01;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Required for association of the cohesin complex with
CC chromatin during interphase. Plays a role in sister chromatid cohesion
CC and normal progression through prometaphase (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with Nipped-B to form the cohesin loading complex.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Note=Binds to
CC chromatin from the end of mitosis until prophase. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SCC4/mau-2 family. {ECO:0000305}.
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DR EMBL; CM000160; EDW97503.1; -; Genomic_DNA.
DR RefSeq; XP_002097791.1; XM_002097755.2.
DR AlphaFoldDB; B4PS83; -.
DR EnsemblMetazoa; FBtr0270793; FBpp0269285; FBgn0241404.
DR GeneID; 6537233; -.
DR KEGG; dya:Dyak_GE24275; -.
DR eggNOG; KOG2300; Eukaryota.
DR HOGENOM; CLU_030238_0_0_1; -.
DR OMA; QDAWYLS; -.
DR OrthoDB; 5360149at2759; -.
DR PhylomeDB; B4PS83; -.
DR Proteomes; UP000002282; Chromosome 3R.
DR GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0032116; C:SMC loading complex; ISS:UniProtKB.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:0034088; P:maintenance of mitotic sister chromatid cohesion; ISS:UniProtKB.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR019440; MAU2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR21394:SF0; MAU2 CHROMATID COHESION FACTOR HOMOLOG; 1.
DR PANTHER; PTHR21394; UNCHARACTERIZED; 1.
DR Pfam; PF10345; Cohesin_load; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Chromosome partition; Mitosis; Nucleus; Repeat;
KW TPR repeat.
FT CHAIN 1..632
FT /note="MAU2 chromatid cohesion factor homolog"
FT /id="PRO_0000382740"
FT REPEAT 453..486
FT /note="TPR 1"
FT REPEAT 493..526
FT /note="TPR 2"
SQ SEQUENCE 632 AA; 71219 MW; 4DB75F56F7E01AA4 CRC64;
MSASTSTSTA ASQDACYISL LGLAEYFRTS QPPNIKKCIQ CLQALFTFMP PSKVEARTHL
QMGQILMAYT KNIDLARQHL EKAWSISEPL PNFDVKFDTA SLLAQLHLQT DKNSHQAKAM
LRRAVELSQN NVYWHCKLLL QLAQIHASDR EYSLASELLA VGAESADEAS ATYLKVLFLL
SRAMILMIER KTNDVLALLN SAGQIIDNNI PNPHQKEYLK VFFLVLQVCY YLALGQVKTV
KPSLKQLQMS IQTIMAPNWP SDEAIFGANQ LEMFVWLPKE QLYVLVYLVT VSHSMMAGYM
DKAQKYTEKA LTQIEKLKQQ EDKPILSVFK VILLEHIVMC RMVMGNRELA IREIAAARDV
CMAAPQRTLL RRHSAQLHCL IGLYSMSTNL FEHAERQFVV CVSETSERDL KLFANLNLAI
IYLRTKRDTD LKQILDAVST ENTHTYSSQA LMGGFYYVQG LHAFHKNSFH EAKRFLRETL
KMANAEDLNR LTSCSLVLLS HVFLSIGNSK ESMNMVTPAM QLASKIPDIH VQLWGSAILK
DLHRMSKDVQ HEKDAYANHV KYSENLIADQ RKCVQSAHHE LVNWFQGDPP VTSGPPATPV
LLMPESSVTS SVPVIASTSA AMQPAGQYGQ FY
//
