GenomeNet

Database: UniProt
Entry: B4PYA4
LinkDB: B4PYA4
Original site: B4PYA4 
ID   UBA5_DROYA              Reviewed;         403 AA.
AC   B4PYA4;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   16-JAN-2019, entry version 51.
DE   RecName: Full=Ubiquitin-like modifier-activating enzyme 5;
DE            Short=Ubiquitin-activating enzyme 5;
GN   ORFNames=GE15940;
OS   Drosophila yakuba (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tai18E2 / Tucson 14021-0261.01;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: E1-like enzyme which activates UFM1. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family. UBA5
CC       subfamily. {ECO:0000305}.
DR   EMBL; CM000162; EDX01966.1; -; Genomic_DNA.
DR   RefSeq; XP_002100858.1; XM_002100822.2.
DR   SMR; B4PYA4; -.
DR   STRING; 7245.FBpp0260950; -.
DR   PRIDE; B4PYA4; -.
DR   EnsemblMetazoa; FBtr0262458; FBpp0260950; FBgn0233497.
DR   GeneID; 6525019; -.
DR   KEGG; dya:Dyak_GE15940; -.
DR   FlyBase; FBgn0233497; Dyak\GE15940.
DR   eggNOG; KOG2336; Eukaryota.
DR   eggNOG; COG0476; LUCA.
DR   KO; K12164; -.
DR   OMA; ETHNYNI; -.
DR   OrthoDB; 1092362at2759; -.
DR   PhylomeDB; B4PYA4; -.
DR   Proteomes; UP000002282; Chromosome X.
DR   Proteomes; UP000002282; Unassembled WGS sequence.
DR   Bgee; FBgn0233497; Expressed in 1 organ(s), highest expression level in adult organism.
DR   GO; GO:0019008; C:molybdopterin synthase complex; IEA:EnsemblMetazoa.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR   GO; GO:0050905; P:neuromuscular process; IEA:EnsemblMetazoa.
DR   InterPro; IPR029752; D-isomer_DH_CS1.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   Pfam; PF00899; ThiF; 1.
DR   SUPFAM; SSF69572; SSF69572; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding;
KW   Ubl conjugation pathway; Zinc.
FT   CHAIN         1    403       Ubiquitin-like modifier-activating enzyme
FT                                5.
FT                                /FTId=PRO_0000391952.
FT   ACT_SITE    249    249       Glycyl thioester intermediate.
FT                                {ECO:0000250}.
FT   METAL       225    225       Zinc. {ECO:0000250}.
FT   METAL       228    228       Zinc. {ECO:0000250}.
FT   METAL       302    302       Zinc. {ECO:0000250}.
FT   METAL       307    307       Zinc. {ECO:0000250}.
FT   BINDING      82     82       ATP; via amide nitrogen. {ECO:0000250}.
FT   BINDING     103    103       ATP. {ECO:0000250}.
FT   BINDING     126    126       ATP. {ECO:0000250}.
FT   BINDING     149    149       ATP. {ECO:0000250}.
FT   BINDING     183    183       ATP. {ECO:0000250}.
SQ   SEQUENCE   403 AA;  44120 MW;  95B66CDDD7944702 CRC64;
     MSHAIDELQA IIAELKTELE EPKATGGVAT NSRLARDRID RMSAEVVDSN PYSRLMALQR
     MNIVKDYERI RDKAVAIVGV GGVGSVTADM LTRCGIGKLI LFDYDKVELA NMNRLFFTPD
     QAGLSKVEAA AATLSFINPD VEIETHNYNI TTVENFDRFL DTISQGGRIA GQPVDLVLSC
     VDNFEARMAI NAACNERNLN WFESGVSENA VSGHIQFIRP GDTACFACAP PLVVAENIDE
     KTLKREGVCA ASLPTTMGIT AGFLVQNALK YLLNFGEVSD YLGYNALSDF FPKMTLKPNP
     QCDDRNCIVR QKEFQARPKP VVIEEKAVSE EPLHATNEWG IELVAEDAPE SNPTPTEAPV
     VGEGLRLAYE APERSSETSE ETVTTAPADE TSLEDLMAQM KSM
//
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