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Database: UniProt
Entry: B4Q510_DROSI
LinkDB: B4Q510_DROSI
Original site: B4Q510_DROSI 
ID   B4Q510_DROSI            Unreviewed;       859 AA.
AC   B4Q510;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   24-JAN-2024, entry version 76.
DE   SubName: Full=GD22547 {ECO:0000313|EMBL:EDX04002.1};
GN   Name=Dsim\GD22547 {ECO:0000313|EMBL:EDX04002.1};
GN   ORFNames=Dsim_GD22547 {ECO:0000313|EMBL:EDX04002.1};
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240 {ECO:0000313|EMBL:EDX04002.1, ECO:0000313|Proteomes:UP000000304};
RN   [1] {ECO:0000313|EMBL:EDX04002.1, ECO:0000313|Proteomes:UP000000304}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=mosaic {ECO:0000313|Proteomes:UP000000304};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA   Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA   Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA   Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA   Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA   Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA   Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA   David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA   Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA   Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA   Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA   Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA   Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA   Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA   Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA   Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA   Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA   Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA   Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA   Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA   McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA   Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA   Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA   Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA   Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA   Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA   Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA   Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA   Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA   Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA   Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA   Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA   Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA   Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA   Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA   Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA   Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA   Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA   Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA   Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA   D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA   Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA   Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA   Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA   Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA   Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA   Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA   Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA   Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA   Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA   Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA   Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA   Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA   Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA   Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA   Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA   Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Postsynaptic density {ECO:0000256|ARBA:ARBA00034105}. Synapse
CC       {ECO:0000256|ARBA:ARBA00034103}.
CC   -!- SIMILARITY: Belongs to the Homer family.
CC       {ECO:0000256|ARBA:ARBA00023606}.
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DR   EMBL; CM000361; EDX04002.1; -; Genomic_DNA.
DR   AlphaFoldDB; B4Q510; -.
DR   SMR; B4Q510; -.
DR   STRING; 7240.B4Q510; -.
DR   EnsemblMetazoa; FBtr0354659; FBpp0319019; FBgn0193948.
DR   HOGENOM; CLU_332965_0_0_1; -.
DR   Proteomes; UP000000304; Chromosome 2l.
DR   Bgee; FBgn0193948; Expressed in embryo and 3 other cell types or tissues.
DR   GO; GO:0030425; C:dendrite; IEA:EnsemblMetazoa.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblMetazoa.
DR   GO; GO:0015630; C:microtubule cytoskeleton; IEA:EnsemblMetazoa.
DR   GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR   GO; GO:0035256; F:G protein-coupled glutamate receptor binding; IEA:InterPro.
DR   GO; GO:0070737; F:protein-glycine ligase activity, elongating; IEA:EnsemblMetazoa.
DR   GO; GO:0070736; F:protein-glycine ligase activity, initiating; IEA:EnsemblMetazoa.
DR   GO; GO:0048149; P:behavioral response to ethanol; IEA:EnsemblMetazoa.
DR   GO; GO:0007216; P:G protein-coupled glutamate receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0045938; P:positive regulation of circadian sleep/wake cycle, sleep; IEA:EnsemblMetazoa.
DR   GO; GO:0018094; P:protein polyglycylation; IEA:EnsemblMetazoa.
DR   GO; GO:0040012; P:regulation of locomotion; IEA:EnsemblMetazoa.
DR   CDD; cd01206; EVH1_Homer_Vesl; 1.
DR   Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR045027; Homer.
DR   InterPro; IPR044100; Homer_EVH1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR004344; TTL/TTLL_fam.
DR   InterPro; IPR000697; WH1/EVH1_dom.
DR   PANTHER; PTHR10918; HOMER; 1.
DR   PANTHER; PTHR10918:SF5; HOMER, ISOFORM E; 1.
DR   Pfam; PF03133; TTL; 1.
DR   Pfam; PF00568; WH1; 1.
DR   SMART; SM00461; WH1; 1.
DR   SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS51221; TTL; 1.
DR   PROSITE; PS50229; WH1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000304};
KW   Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT   DOMAIN          463..575
FT                   /note="WH1"
FT                   /evidence="ECO:0000259|PROSITE:PS50229"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          581..643
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          706..822
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        7..25
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   859 AA;  96612 MW;  915DD164AC9C2C66 CRC64;
     MQTRPSSEPH RSRDQVTDGD RNRDQPQKCA SATLAKKPKC ERNIMSRFLE HMPVDFLWTN
     RKEKCDYIDQ AKNPGMTINK FHRAPFTSKE GLCSQLRDFH WFFEEGTAEM YFPRCYNVWS
     PEELGEFIEN FKLTACVAFL RAMLCKYHKQ GSDAVFSCSG KIPYSAIDFA YKRLVEFIDS
     CQHNDIDFED PPKIWEHEWD AFLFQHQQLV NEDGRIQHDG GQRLEPMVKS CLSLVDKMKV
     HWPQYSLDGY QNLWIVKPAN KCRGRGIILM DNLKKILGVV NPSIASKSRY VVQKYIERPL
     ILFQTKFDIR QWFLITNTQP LVVWFYRESY LRFSSQEYSL SNHHESVHLT NYAHQKSTPM
     ESGTAPAQRE HVGLLLLPGV PPSNWQVQHV VGAYISRNAQ GHRWLYAGLP GEHGPTAQHL
     RVFRRGLHDL REFLSLAHRD QLQSGSRSHH ECDGAHVSPV FGGCCQGEQP IFTCQAHVFH
     IDPKTKRTWI TASMKAVNVS FFYDSSRNLY RIISVEGTKA VINSTITPNM TFTQTSQKFG
     QWSDVRANTV YGLGFASEAE LTKFVEKFQE VKEATKNAMK SANGSNAVTP TTSANTSPIS
     GRAVGSMQND NTAIDPHTVE PPNMSNTNTQ NANPDSPSHK LLNTSDVKAD IGSATPSPQP
     TSGVTGGGGV TISSGGSIVG MHTGPGAGAT AEQQLKYENE RLKMALAQSC ANAKKWEIEL
     ATLKNNNIRL TSALQESTAN VDEWKRQLHT YKEENIRLKR DMEQLCVGGG GVAAAGGGAT
     EDELRREVAT LKARTEQLQK ELMQQELELK SANISLREKS NDQTLAKLSE VNGVFAKHLS
     ELYGVQKDME SIIQLAKCT
//
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