ID B4R0N8_DROSI Unreviewed; 1932 AA.
AC B4R0N8;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=GD20972 {ECO:0000313|EMBL:EDX13961.1};
GN Name=Dsim\GD20972 {ECO:0000313|EMBL:EDX13961.1};
GN ORFNames=Dsim_GD20972 {ECO:0000313|EMBL:EDX13961.1};
OS Drosophila simulans (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7240 {ECO:0000313|EMBL:EDX13961.1, ECO:0000313|Proteomes:UP000000304};
RN [1] {ECO:0000313|EMBL:EDX13961.1, ECO:0000313|Proteomes:UP000000304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=mosaic {ECO:0000313|Proteomes:UP000000304};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
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DR EMBL; CM000364; EDX13961.1; -; Genomic_DNA.
DR STRING; 7240.B4R0N8; -.
DR EnsemblMetazoa; FBtr0358410; FBpp0322412; FBgn0192428.
DR HOGENOM; CLU_001991_1_0_1; -.
DR OMA; THWADIA; -.
DR PhylomeDB; B4R0N8; -.
DR Proteomes; UP000000304; Chromosome 3r.
DR Bgee; FBgn0192428; Expressed in embryo and 3 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:EnsemblMetazoa.
DR GO; GO:0005819; C:spindle; IEA:EnsemblMetazoa.
DR GO; GO:0050811; F:GABA receptor binding; IEA:EnsemblMetazoa.
DR GO; GO:0055059; P:asymmetric neuroblast division; IEA:EnsemblMetazoa.
DR GO; GO:0098722; P:asymmetric stem cell division; IEA:EnsemblMetazoa.
DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:EnsemblMetazoa.
DR GO; GO:0045938; P:positive regulation of circadian sleep/wake cycle, sleep; IEA:EnsemblMetazoa.
DR GO; GO:0061172; P:regulation of establishment of bipolar cell polarity; IEA:EnsemblMetazoa.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00063; FN3; 1.
DR CDD; cd17117; RA_ANKFN1_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR039269; ANKFN1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000159; RA_dom.
DR PANTHER; PTHR21437; UNCHARACTERIZED; 1.
DR PANTHER; PTHR21437:SF1; WIDE AWAKE; 1.
DR Pfam; PF00788; RA; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50200; RA; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000000304}.
FT REPEAT 503..528
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 620..723
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1816..1917
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1551..1590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1779..1808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..299
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..321
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..427
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..457
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1551..1578
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1785..1808
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1932 AA; 214152 MW; 82DBE0E7084F5554 CRC64;
MERRKALSSY AKFKDQQEAA AAVTPQKNNE SEDSLPALRR SHSVRSSLRR LKNKLHSPAL
SMQSPFKLRT QLHMRNRSSR GSATLDKSKA AKALRMLGDL DAVAVLTTKV KGKNEFVPLK
RAMNSDSCDH DELGIERLMS SLPVGAKLPR KACKLLQIPE SYCRQTELAP KATLDSDLEK
TFSGEESSAV LADITRHAQQ GIYGTTRMRT ATIRKPMPYL NSRRCYHSDS TKLPNMPQKL
PMSSCLRSPA VFVRQKSFHT LNELTRFCQL KVSPHRATGT ATSTSSSSPS SSPAAAQQQR
RHSHYAIDDN ILPQDKRDGD IDSVRLREKV VNPSGGNNNN QDNYPTYYPA PLLSTSRWSE
QLTQHAAVAK IRTAISCHSQ DLKEMEFLLP HSRTDSQSNS QSQLCISRHS QPKNAKLRDD
HDETGSSELD SPPLGDENAS ANGQLSVHRQ PVQLRSKIPG NTPHPRASKM SKKQLKLAQA
QLDKLTQNNL HLHVSLSLFI NNDGLSALDL AVLSNNRSMT RMLLQHGAVE GSQFSVDTIG
TKLNGLLKDA ESRIHDLSGP EGLCPPVFAS RPSISSIIIG NSSASVTGCT GSEVEKQIGI
WERRVKGLRR LQLGWDQARP PDAPASVVVD VTGDNSISVQ ILEPFEGAIG TKFKVQWSTR
ADFNNVVGES ELLEWISFHG TMGAQCHISG LTQGRRYFLR AACGNVKGWG TYRTSVPASV
VPSTWRDLDN REDRFVGRHR ILDNLFTAVR LARPADVSEL TLDPASAQRR NPKKKTTIKQ
LFSVTTKFQK TLRRGIYFSC IIHCDDKVLV TSEDFPPVIE VDESYPSALH MDYYWLMKVA
CTWEDVKSLR SDMERNLTSA VHFRTKLLSA VCQMQSALGI TDLGQLYYKP LRDAQGTVVL
TCVQSVKSQK AVSILNSRWV PVSKLQKKLG ALHEDYTINE LLISSIGDQL HYQQAALQRL
EPGLYLGYLK MQCSMDQIQV VVPVKTPNVL PHCKVRENSH ITAEEWQGRR YFLRAACGNV
KGWGTYRTSV PASVVPSTWR DLDNREDRFV GRHRILDNLF TAVRLARPAD VSELTLDPAS
AQRRNPKKKT TIKQLFSVTT KFQKTLRRGI YFSCIIHCDD KVLVTSEDFP PVIEVDESYP
SALHMDYYWL MKVACTWEDV KSLRSDMERN LTSAVHFRTK LLSAVCQMQS ALGITDLGQL
YYKPLRDAQG TVVLTCVQSV KSQKAVSILN SRWVPVSKLQ KKLGALHEDY TINELLISSI
GDQLHYQQAA LQRLEPGLYL GYLKMQCSMD QIQVVVPVKT PNVLPHCKVR ENSHITAEEW
QVLHRCSSDP LRLPLDFSAQ GGDAASGGTA TTEVQRLFLY DLTNAMHKLF ASMNIKIADA
TTHRLYDVEV IEHSPDISFL VVCPSAESSC AVPGQSELLL QRDDLASLSI QAFEMIHLRT
YQPAIIQKYA RLSCILELDT ALATHSLREA FSSSELQAAK ERLATLQELS ASLTIVWKSV
RWLMDVVAYA RNKNAQPSLA MREILDFAQQ RQDESVATSA GGSANKQLLQ LPIRESKFSK
TGQGRGSWPG PGTSEDQSQN KPEHSKSEQN LELSAITPVE PATNQVPTQQ QQPQQQSQQQ
QLLQVSNISE YAGSICSEVS FRKNSGDSMS STYTSRSFYS AVDSASDGNS TNSVFAIPPS
RSDDTLADAL RHSQAVAAQR KRTSSNIASH TNPLITVHSS SSAPYLAGSS VSLRSGNGAF
ATDLEHKPLK PATKAASSAN LREGGPYLKS TLAELRAVGG EEPVASTSKA SSMKSLSRQS
SEEDSASCSS LNAEQTSGII QVYTAYSTGL ASGTSLKIHV TPKTTAREVI NLVVKQLNMA
VVLKGNNGPI YGPEMLENFC LVAVIGARER CLRDDFKPLQ LQNPWKKGRL YVRKKHELLA
AIEHSNRKSH LI
//
