GenomeNet

Database: UniProt
Entry: B4R345
LinkDB: B4R345
Original site: B4R345 
ID   UBA5_DROSI              Reviewed;         404 AA.
AC   B4R345; B4F5T5;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 2.
DT   16-JAN-2019, entry version 49.
DE   RecName: Full=Ubiquitin-like modifier-activating enzyme 5;
DE            Short=Ubiquitin-activating enzyme 5;
GN   ORFNames=GD17028;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ALA-111.
RC   STRAIN=S1;
RX   PubMed=18477586; DOI=10.1093/molbev/msn111;
RA   Baines J.F., Sawyer S.A., Hartl D.L., Parsch J.;
RT   "Effects of X-linkage and sex-biased gene expression on the rate of
RT   adaptive protein evolution in Drosophila.";
RL   Mol. Biol. Evol. 25:1639-1650(2008).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: E1-like enzyme which activates UFM1. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family. UBA5
CC       subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDX17647.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
DR   EMBL; AM999171; CAQ53533.1; -; Genomic_DNA.
DR   EMBL; CM000366; EDX17647.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_016038940.1; XM_016173754.1.
DR   SMR; B4R345; -.
DR   PRIDE; B4R345; -.
DR   GeneID; 6725682; -.
DR   KEGG; dsi:Dsimw501_GD17028; -.
DR   FlyBase; FBgn0188603; Dsim\GD17028.
DR   KO; K12164; -.
DR   Proteomes; UP000000304; Chromosome X.
DR   Proteomes; UP000000304; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR   InterPro; IPR029752; D-isomer_DH_CS1.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   Pfam; PF00899; ThiF; 1.
DR   SUPFAM; SSF69572; SSF69572; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding;
KW   Reference proteome; Ubl conjugation pathway; Zinc.
FT   CHAIN         1    404       Ubiquitin-like modifier-activating enzyme
FT                                5.
FT                                /FTId=PRO_0000391949.
FT   ACT_SITE    250    250       Glycyl thioester intermediate.
FT                                {ECO:0000250}.
FT   METAL       226    226       Zinc. {ECO:0000250}.
FT   METAL       229    229       Zinc. {ECO:0000250}.
FT   METAL       303    303       Zinc. {ECO:0000250}.
FT   METAL       308    308       Zinc. {ECO:0000250}.
FT   BINDING      83     83       ATP; via amide nitrogen. {ECO:0000250}.
FT   BINDING     104    104       ATP. {ECO:0000250}.
FT   BINDING     127    127       ATP. {ECO:0000250}.
FT   BINDING     150    150       ATP. {ECO:0000250}.
FT   BINDING     184    184       ATP. {ECO:0000250}.
FT   VARIANT     111    111       D -> A (in strain: S1).
FT                                {ECO:0000269|PubMed:18477586}.
SQ   SEQUENCE   404 AA;  44200 MW;  48FC21AD03557EA9 CRC64;
     MSHAIDELQA IIADLKTELE TEPKSSVGVA SNSRLARDRI DRMSAEVVDS NPYSRLMALQ
     RMNIVKDYER IRDKAVAIVG VGGVGSVTAD MLTRCGIGKL ILFDYDKVEL DNMNRLFFTP
     DQAGLSKVAA AAATLSFINP DVEIETHNYN ITTVENFDRF LDTISQGGRI AGQPVDLVLS
     CVDNFEARMA INAACNERNL NWFESGVSEN AVSGHIQFIR PGDTACFACA PPLVVAENID
     EKTLKREGVC AASLPTTMGI TAGFLVQNAL KYLLNFGEVS DYLGYNALSD FFPKMTLKPN
     PQCDDRNCIV RQKEFQARPK PVVIEEKAVS EEPLHATNEW GIELVAEDAP QSNPTPAETP
     VMGEGLRLAY EAPEKSSETS EETVTAATAD ETSLEDLMAQ MKSM
//
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