ID B4R815_PHEZH Unreviewed; 358 AA.
AC B4R815;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
GN OrderedLocusNames=PHZ_c1134 {ECO:0000313|EMBL:ACG77548.1};
OS Phenylobacterium zucineum (strain HLK1).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Phenylobacterium.
OX NCBI_TaxID=450851 {ECO:0000313|EMBL:ACG77548.1, ECO:0000313|Proteomes:UP000001868};
RN [1] {ECO:0000313|EMBL:ACG77548.1, ECO:0000313|Proteomes:UP000001868}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HLK1 {ECO:0000313|EMBL:ACG77548.1,
RC ECO:0000313|Proteomes:UP000001868};
RX PubMed=18700039; DOI=10.1186/1471-2164-9-386;
RA Luo Y., Xu X., Ding Z., Liu Z., Zhang B., Yan Z., Sun J., Hu S., Hu X.;
RT "Complete genome of Phenylobacterium zucineum - a novel facultative
RT intracellular bacterium isolated from human erythroleukemia cell line
RT K562.";
RL BMC Genomics 9:386-386(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IB topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00006645}.
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DR EMBL; CP000747; ACG77548.1; -; Genomic_DNA.
DR AlphaFoldDB; B4R815; -.
DR STRING; 450851.PHZ_c1134; -.
DR KEGG; pzu:PHZ_c1134; -.
DR eggNOG; COG3569; Bacteria.
DR HOGENOM; CLU_046978_1_1_5; -.
DR OrthoDB; 9778962at2; -.
DR Proteomes; UP000001868; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:InterPro.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR Gene3D; 1.10.132.120; -; 1.
DR Gene3D; 3.30.66.10; DNA topoisomerase I domain; 1.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR035447; DNA_topo_I_N_sf.
DR InterPro; IPR049331; Top1B_N_bact.
DR InterPro; IPR001631; TopoI.
DR InterPro; IPR014711; TopoI_cat_a-hlx-sub_euk.
DR InterPro; IPR013500; TopoI_cat_euk.
DR Pfam; PF21338; Top1B_N_bact; 1.
DR Pfam; PF01028; Topoisom_I; 1.
DR PRINTS; PR00416; EUTPISMRASEI.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR SUPFAM; SSF55869; DNA topoisomerase I domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:ACG77548.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001868};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 35..83
FT /note="DNA topoisomerase IB N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21338"
FT DOMAIN 95..320
FT /note="DNA topoisomerase I catalytic core eukaryotic-type"
FT /evidence="ECO:0000259|Pfam:PF01028"
SQ SEQUENCE 358 AA; 39646 MW; 476E63E8294B5CFA CRC64;
MPNDVAAAEH IEEAGLRYVS DGDPGIARKP ARGHGFNYLA PNGEPVTDEK TLDRIRALAI
PPAWTDVWIC PRANGHIQAV GRDQKGRKQY RYHARWREVR DSHKYDRVLA FGRALPRLRR
RVEEDLKRPG LPREKVLAAV IRVMETTLIR VGNEEYAKQN RSFGLTTLRD RHVKVGRAGA
VFEFRGKSGK VHKTGLNDRR LARIVKACQD LPGQRLFQYV GDDGLQHAVE SADVNAYLRD
ALGEDFSAKD FRTWAGTVMA ARALMETPAC ASAAEAKRNV STCVKAVAGV LGNTAAVARS
AYIHPAVLEA YQDGALEVKA SGSDERAFEL AVLRFLEGVR DDDPQKKTAA AREMARKA
//
