ID B4SEV7_PELPB Unreviewed; 264 AA.
AC B4SEV7;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=CRISPR-associated endoribonuclease {ECO:0000256|PIRNR:PIRNR005054};
GN OrderedLocusNames=Ppha_2448 {ECO:0000313|EMBL:ACF44633.1};
OS Pelodictyon phaeoclathratiforme (strain DSM 5477 / BU-1).
OC Bacteria; Chlorobiota; Chlorobiia; Chlorobiales; Chlorobiaceae;
OC Chlorobium/Pelodictyon group; Pelodictyon.
OX NCBI_TaxID=324925 {ECO:0000313|EMBL:ACF44633.1, ECO:0000313|Proteomes:UP000002724};
RN [1] {ECO:0000313|EMBL:ACF44633.1, ECO:0000313|Proteomes:UP000002724}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 5477 / BU-1 {ECO:0000313|Proteomes:UP000002724};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Mikhailova N., Liu Z., Li T., Zhao F., Overmann J.,
RA Bryant D.A., Richardson P.;
RT "Complete sequence of Pelodictyon phaeoclathratiforme BU-1.";
RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC repeat), is an adaptive immune system that provides protection against
CC mobile genetic elements (viruses, transposable elements and conjugative
CC plasmids). CRISPR clusters contain sequences complementary to
CC antecedent mobile elements and target invading nucleic acids. CRISPR
CC clusters are transcribed and processed into CRISPR RNA (crRNA).
CC {ECO:0000256|PIRNR:PIRNR005054}.
CC -!- SIMILARITY: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE
CC family. {ECO:0000256|ARBA:ARBA00005937, ECO:0000256|PIRNR:PIRNR005054}.
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DR EMBL; CP001110; ACF44633.1; -; Genomic_DNA.
DR RefSeq; WP_012509107.1; NC_011060.1.
DR AlphaFoldDB; B4SEV7; -.
DR STRING; 324925.Ppha_2448; -.
DR KEGG; pph:Ppha_2448; -.
DR eggNOG; COG1583; Bacteria.
DR HOGENOM; CLU_089858_0_0_10; -.
DR OrthoDB; 9797488at2; -.
DR Proteomes; UP000002724; Chromosome.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd21140; Cas6_I-like; 1.
DR Gene3D; 3.30.70.1890; -; 1.
DR Gene3D; 3.30.70.1900; -; 1.
DR InterPro; IPR049435; Cas_Cas6_C.
DR InterPro; IPR010156; CRISPR-assoc_prot_Cas6.
DR InterPro; IPR045747; CRISPR-assoc_prot_Cas6_N_sf.
DR NCBIfam; TIGR01877; cas_cas6; 1.
DR PANTHER; PTHR36984; CRISPR-ASSOCIATED ENDORIBONUCLEASE CAS6 1; 1.
DR PANTHER; PTHR36984:SF1; CRISPR-ASSOCIATED ENDORIBONUCLEASE CAS6 1; 1.
DR Pfam; PF21350; Cas6_I-A; 1.
DR Pfam; PF01881; Cas_Cas6_C; 1.
DR PIRSF; PIRSF005054; PF1131; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW Reference proteome {ECO:0000313|Proteomes:UP000002724};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 127..261
FT /note="CRISPR associated protein Cas6 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01881"
FT ACT_SITE 29
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005054-50"
FT ACT_SITE 44
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005054-50"
FT SITE 56
FT /note="Transition state stabilizer"
FT /evidence="ECO:0000256|PIRSR:PIRSR005054-1"
SQ SEQUENCE 264 AA; 30386 MW; 638F4D3DCC666497 CRC64;
MRITLELSHR KRTVTLPINN SHLISSLIYN IVDKSSSEYA ERLHDQGYRL QNRAFKLFTF
SPLYPGNRHK WVMHENGTMS TADALLHVTI SSPKEEFVEH LVIGLLQEPY VWVGNERFRV
ETVRKLDQPE LSDDMEFVML SPLVCTTKGE ADHYPQYLYP GDPEFERVLL ENLCRKYQVL
HGRSFVCESG QFGFAIDEAY VERMQGKVQK LITLKEGRSD ETKIKGTLAP FRLRAPRELM
EVGYACGFGE KNSMGFGMVK VDEA
//
