ID B4U6L3_HYDS0 Unreviewed; 626 AA.
AC B4U6L3;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=acetate--CoA ligase {ECO:0000256|ARBA:ARBA00013275};
DE EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
GN ORFNames=HY04AAS1_0089 {ECO:0000313|EMBL:ACG56781.1};
OS Hydrogenobaculum sp. (strain Y04AAS1).
OC Bacteria; Aquificota; Aquificae; Aquificales; Aquificaceae;
OC Hydrogenobaculum.
OX NCBI_TaxID=380749 {ECO:0000313|EMBL:ACG56781.1};
RN [1] {ECO:0000313|EMBL:ACG56781.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Y04AAS1 {ECO:0000313|EMBL:ACG56781.1};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Chertkov O., Kiss H., Brettin T.,
RA Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Mikhailova N., Resenback A.-L., Mead D.;
RL Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACG56781.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Y04AAS1 {ECO:0000313|EMBL:ACG56781.1};
RX PubMed=19136599; DOI=10.1128/JB.01645-08;
RA Reysenbach A.L., Hamamura N., Podar M., Griffiths E., Ferreira S.,
RA Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A.,
RA Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A.;
RT "Complete and draft genome sequences of six members of the Aquificales.";
RL J. Bacteriol. 191:1992-1993(2009).
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DR EMBL; CP001130; ACG56781.1; -; Genomic_DNA.
DR AlphaFoldDB; B4U6L3; -.
DR STRING; 380749.HY04AAS1_0089; -.
DR KEGG; hya:HY04AAS1_0089; -.
DR eggNOG; COG0365; Bacteria.
DR HOGENOM; CLU_000022_3_6_0; -.
DR OrthoDB; 9778383at2; -.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:InterPro.
DR GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR CDD; cd05966; ACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR011904; Ac_CoA_lig.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ACG56781.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 28..81
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 91..469
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 525..603
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 626 AA; 70175 MW; 5FD142263021063C CRC64;
MNDEVLLKVE EKINPPSRIL EEAHIKDYES IYKKSIENPD AFWAEAAQDI TWFKPFSKVL
EWNFPYAKWF LDGKLNASYN CLDRHIEEGL RNKVAYIGVN EDLEEKKITY GELLELVNRL
ANALKSLGLK KGDRVSIYMP NTVEAVASML ACARIGLIHQ VVFAGFSEGA LRTRVEDAGA
SAIITATYTK RRGKKVELLP TALEAIKGLD SIKHVICWDR DNAGLPEGVL GFYDIVKSQK
PECEPEHMDS EDPLFILYTS GTTGKPKGVI HTTGGYMVNV HFTTKNVFAL KPNDIYWCTA
DIGWITGHSY IVYGPLSVGV TSVIFEGAPD YKDPSTWWKI VEKYRVNKFY TAPTAVRLFM
KYGEQWPEAH DLSSLKILGS VGEPINPEAW HWYYEHIGHK NCAIVDTWWQ TETGTHMITT
LPGNPMKPGK AGKPLPGIEV AIVDKNGNPV PPNTVGYVVI KNPWPSMMRN CWGQPERYKK
YWTEIPGNVY NADDLGSIDE EGDIMIVGRA DDVLSVAGHR IGTMEVESAI VDHEAVAEAA
VIGKPDPIKG ERIKAFVILK QDYNPSEELK KSIQEHVKHV LGAIAYPEEI EFVDKLPKTR
SGKIMRRVLK AKELGLDIGD VSTLED
//
