ID B4V3X5_9ACTN Unreviewed; 496 AA.
AC B4V3X5;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Amidohydrolase {ECO:0000313|EMBL:AKL66163.1};
DE SubName: Full=Aminopeptidase {ECO:0000313|EMBL:EDX22662.1};
GN ORFNames=M444_12925 {ECO:0000313|EMBL:AKL66163.1}, SSAG_02453
GN {ECO:0000313|EMBL:EDX22662.1};
OS Streptomyces sp. Mg1.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=465541 {ECO:0000313|EMBL:EDX22662.1, ECO:0000313|Proteomes:UP000005764};
RN [1] {ECO:0000313|EMBL:EDX22662.1, ECO:0000313|Proteomes:UP000005764}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mg1 {ECO:0000313|EMBL:EDX22662.1,
RC ECO:0000313|Proteomes:UP000005764};
RG The Broad Institute Genome Sequencing Platform;
RA Fischbach M., Ward D., Young S., Jaffe D., Gnerre S., Berlin A., Heiman D.,
RA Hepburn T., Sykes S., Mehta T., Alvarado L., Kodira C.D., Straight P.,
RA Clardy J., Hung D., Kolter R., Mekalanos J., Walker S., Walsh C.T.,
RA Lander E., Galagan J., Nusbaum C., Birren B.;
RT "Annotation of Streptomyces sp. Mg1.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AKL66163.1, ECO:0000313|Proteomes:UP000035653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mg1 {ECO:0000313|EMBL:AKL66163.1,
RC ECO:0000313|Proteomes:UP000035653};
RX PubMed=23908282;
RA Hoefler B.C., Konganti K., Straight P.D.;
RT "De Novo Assembly of the Streptomyces sp. Strain Mg1 Genome Using PacBio
RT Single-Molecule Sequencing.";
RL Genome Announc. 1:e00535-13(2013).
RN [3] {ECO:0000313|EMBL:AKL66163.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Mg1 {ECO:0000313|EMBL:AKL66163.1};
RA Hoefler B.C., Straight P.D.;
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28A subfamily.
CC {ECO:0000256|ARBA:ARBA00005957}.
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DR EMBL; CP011664; AKL66163.1; -; Genomic_DNA.
DR EMBL; DS570393; EDX22662.1; -; Genomic_DNA.
DR RefSeq; WP_008739033.1; NZ_DS570393.1.
DR AlphaFoldDB; B4V3X5; -.
DR STRING; 465541.M444_12925; -.
DR KEGG; strm:M444_12925; -.
DR PATRIC; fig|465541.12.peg.2814; -.
DR eggNOG; COG2234; Bacteria.
DR HOGENOM; CLU_024336_0_2_11; -.
DR OrthoDB; 345880at2; -.
DR Proteomes; UP000005764; Unassembled WGS sequence.
DR Proteomes; UP000035653; Chromosome.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008235; F:metalloexopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd03876; M28_SGAP_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR045175; M28_fam.
DR InterPro; IPR041756; M28_SGAP-like.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR006311; TAT_signal.
DR PANTHER; PTHR12147; METALLOPEPTIDASE M28 FAMILY MEMBER; 1.
DR PANTHER; PTHR12147:SF55; PEPTIDE HYDROLASE; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS51318; TAT; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000256|ARBA:ARBA00022438,
KW ECO:0000313|EMBL:EDX22662.1}; Hydrolase {ECO:0000313|EMBL:AKL66163.1};
KW Protease {ECO:0000256|ARBA:ARBA00022438, ECO:0000313|EMBL:EDX22662.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000035653};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..37
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 38..496
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014085221"
FT DOMAIN 145..234
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 260..483
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
SQ SEQUENCE 496 AA; 51444 MW; 59DFAF0220A59240 CRC64;
MRAIRHRRRS IPALAALAAA AVAAPVLLTA APAAAHAHDQ RGGELARELV EEVTARGAYR
HLARFQRIAD ANGGNRAAGT PGHLASAAYV HDTLKKAGYE VSYQDFDIYE AHTKTEKTTV
LGAEPRELAT AAFTFTPSTP AAGLTAPLAL ARVDETPGCT ADDYPAGAFT GKIALVKRGS
CTFVEKQNAA AAAGAAGVIV YNHSGTTPVR GGFSSPAEGL IPSAGITLAE GEALAAAAAG
GEVRVRLDLE QEHVRKTTRN VIAQTKGGRA DRVVTAGAHL DSVPEGPGIN DNGSGSAGLL
EVALKFADEG ANKKGKGPAN KVRFAWWSAE ELGLLGSEHY VAQLSARQRK DIALYLNFDM
IASPNPVQFV YDGDDSDKTG EGAGPAGSAQ IEALINGFLD KKGKPHEGSD FDGRSDYGPF
IANGIPAGGT FTGAEGIKTA EQAKRYGGTA GAAYDPNYHG AGDDLKNLDL KAFDTNLDVI
AHAVGTYAHD LRSLGK
//
