ID B4V5Y1_9ACTN Unreviewed; 649 AA.
AC B4V5Y1;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Succinate dehydrogenase {ECO:0000313|EMBL:AKL68885.1, ECO:0000313|EMBL:EDX23368.1};
DE EC=1.3.5.1 {ECO:0000313|EMBL:AKL68885.1};
GN Name=sdhA {ECO:0000313|EMBL:AKL68885.1};
GN ORFNames=M444_29530 {ECO:0000313|EMBL:AKL68885.1}, SSAG_03159
GN {ECO:0000313|EMBL:EDX23368.1};
OS Streptomyces sp. Mg1.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=465541 {ECO:0000313|EMBL:EDX23368.1, ECO:0000313|Proteomes:UP000005764};
RN [1] {ECO:0000313|EMBL:EDX23368.1, ECO:0000313|Proteomes:UP000005764}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mg1 {ECO:0000313|EMBL:EDX23368.1,
RC ECO:0000313|Proteomes:UP000005764};
RG The Broad Institute Genome Sequencing Platform;
RA Fischbach M., Ward D., Young S., Jaffe D., Gnerre S., Berlin A., Heiman D.,
RA Hepburn T., Sykes S., Mehta T., Alvarado L., Kodira C.D., Straight P.,
RA Clardy J., Hung D., Kolter R., Mekalanos J., Walker S., Walsh C.T.,
RA Lander E., Galagan J., Nusbaum C., Birren B.;
RT "Annotation of Streptomyces sp. Mg1.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AKL68885.1, ECO:0000313|Proteomes:UP000035653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mg1 {ECO:0000313|EMBL:AKL68885.1,
RC ECO:0000313|Proteomes:UP000035653};
RX PubMed=23908282;
RA Hoefler B.C., Konganti K., Straight P.D.;
RT "De Novo Assembly of the Streptomyces sp. Strain Mg1 Genome Using PacBio
RT Single-Molecule Sequencing.";
RL Genome Announc. 1:e00535-13(2013).
RN [3] {ECO:0000313|EMBL:AKL68885.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Mg1 {ECO:0000313|EMBL:AKL68885.1};
RA Hoefler B.C., Straight P.D.;
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP011664; AKL68885.1; -; Genomic_DNA.
DR EMBL; DS570399; EDX23368.1; -; Genomic_DNA.
DR RefSeq; WP_008740278.1; NZ_DS570399.1.
DR AlphaFoldDB; B4V5Y1; -.
DR STRING; 465541.M444_29530; -.
DR KEGG; strm:M444_29530; -.
DR PATRIC; fig|465541.12.peg.6240; -.
DR eggNOG; COG1053; Bacteria.
DR HOGENOM; CLU_014312_7_0_11; -.
DR OrthoDB; 9805351at2; -.
DR Proteomes; UP000005764; Unassembled WGS sequence.
DR Proteomes; UP000035653; Chromosome.
DR GO; GO:0102040; F:fumarate reductase (menaquinone); IEA:UniProtKB-EC.
DR GO; GO:0033765; F:steroid dehydrogenase activity, acting on the CH-CH group of donors; IEA:UniProt.
DR GO; GO:0008177; F:succinate dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 1.20.58.100; Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain; 1.
DR Gene3D; 3.90.700.10; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR InterPro; IPR003953; FAD-binding_2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR037099; Fum_R/Succ_DH_flav-like_C_sf.
DR InterPro; IPR015939; Fum_Rdtase/Succ_DH_flav-like_C.
DR InterPro; IPR030664; SdhA/FrdA/AprA.
DR InterPro; IPR011280; Succ_DH/Fum_Rdt_flav_su.
DR InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR NCBIfam; TIGR01811; sdhA_Bsu; 1.
DR PANTHER; PTHR11632; SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT; 1.
DR PANTHER; PTHR11632:SF53; SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT; 1.
DR Pfam; PF00890; FAD_binding_2; 1.
DR Pfam; PF02910; Succ_DH_flav_C; 1.
DR PRINTS; PR00368; FADPNR.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF46977; Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain; 1.
DR SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
PE 4: Predicted;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:AKL68885.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000035653}.
FT DOMAIN 47..452
FT /note="FAD-dependent oxidoreductase 2 FAD binding"
FT /evidence="ECO:0000259|Pfam:PF00890"
FT DOMAIN 514..648
FT /note="Fumarate reductase/succinate dehydrogenase
FT flavoprotein-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02910"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 341
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR630664-50"
SQ SEQUENCE 649 AA; 71723 MW; 589EF376C09ED715 CRC64;
MSEYANYTTG EPISDTKAPE GPIAERWDRR RFEAKLVNPA NRRKHTVIVV GTGLAGGAAG
ATLAEQGYHV VQFCYSDSPR RAHSIAAQGG INAAKNYRND GDSVHRLFYD TVKGGDFRAR
ESNVHRLAQI SVEIIDQCVA QGVPFAREYG GLLDTRSFGG VQVSRTFYAR GQTGQQLLLG
AYQALSRQIA AGNVEMHART EMLDLITVDG VARGIVARDL ITGSIETHYA DAVVLASGGY
GNVFYLSTNA MNSNATAIWR AHRRGAHFAN PCFTQIHPTC IPRTGDHQSK LTLMSESLRN
DGRIWVPKAK GDTRPAAEIP EAERDYYLER IYPSFGNLVP RDIASRAAKN VCDEGRGVGP
GGQGVYLDFA DAIRRMGRGQ VAEKYGNLFE MYERITAENP YEVPMRIYPA VHYTMGGLWV
DYDLQTTVPG LFAIGEANFS DHGANRLGAS ALMQGLGDGY FVLPSTINDY LARHPHQDSV
DDDHPEAAAA IRETRDCLAK LLAVDGDRTP DSFHREIGEL MWEYCGMART DAGLRKALAR
IPEIREEFWR RIKVPGSGAE FNQSLEKANR IVDYLELAEL MCLDALHRAE SCGGHFREES
QTPDGEAARR DEEFGYAAAW EYQGTGAAPV LHKEDLVFEY VHPTQRSYA
//
