ID B4V619_9ACTN Unreviewed; 534 AA.
AC B4V619;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE SubName: Full=Choline dehydrogenase {ECO:0000313|EMBL:EDX23406.1};
DE SubName: Full=Glucose-methanol-choline oxidoreductase {ECO:0000313|EMBL:AKL65274.1};
GN ORFNames=M444_07610 {ECO:0000313|EMBL:AKL65274.1}, SSAG_03197
GN {ECO:0000313|EMBL:EDX23406.1};
OS Streptomyces sp. Mg1.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=465541 {ECO:0000313|EMBL:EDX23406.1, ECO:0000313|Proteomes:UP000005764};
RN [1] {ECO:0000313|EMBL:EDX23406.1, ECO:0000313|Proteomes:UP000005764}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mg1 {ECO:0000313|EMBL:EDX23406.1,
RC ECO:0000313|Proteomes:UP000005764};
RG The Broad Institute Genome Sequencing Platform;
RA Fischbach M., Ward D., Young S., Jaffe D., Gnerre S., Berlin A., Heiman D.,
RA Hepburn T., Sykes S., Mehta T., Alvarado L., Kodira C.D., Straight P.,
RA Clardy J., Hung D., Kolter R., Mekalanos J., Walker S., Walsh C.T.,
RA Lander E., Galagan J., Nusbaum C., Birren B.;
RT "Annotation of Streptomyces sp. Mg1.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AKL65274.1, ECO:0000313|Proteomes:UP000035653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mg1 {ECO:0000313|EMBL:AKL65274.1,
RC ECO:0000313|Proteomes:UP000035653};
RX PubMed=23908282;
RA Hoefler B.C., Konganti K., Straight P.D.;
RT "De Novo Assembly of the Streptomyces sp. Strain Mg1 Genome Using PacBio
RT Single-Molecule Sequencing.";
RL Genome Announc. 1:e00535-13(2013).
RN [3] {ECO:0000313|EMBL:AKL65274.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Mg1 {ECO:0000313|EMBL:AKL65274.1};
RA Hoefler B.C., Straight P.D.;
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
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DR EMBL; CP011664; AKL65274.1; -; Genomic_DNA.
DR EMBL; DS570400; EDX23406.1; -; Genomic_DNA.
DR RefSeq; WP_008740368.1; NZ_DS570400.1.
DR AlphaFoldDB; B4V619; -.
DR STRING; 465541.M444_07610; -.
DR KEGG; strm:M444_07610; -.
DR PATRIC; fig|465541.12.peg.1724; -.
DR eggNOG; COG2303; Bacteria.
DR HOGENOM; CLU_002865_7_2_11; -.
DR OrthoDB; 9785276at2; -.
DR Proteomes; UP000005764; Unassembled WGS sequence.
DR Proteomes; UP000035653; Chromosome.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.30.560.10; Glucose Oxidase, domain 3; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR11552:SF147; CHOLINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 2.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Reference proteome {ECO:0000313|Proteomes:UP000035653}.
FT DOMAIN 280..294
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00624"
FT REGION 137..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 534 AA; 57533 MW; 1929A9BF5834B4CB CRC64;
MAVNGTDEYD YVIVGSGTAG SILANRLSED PDVSVLVLEA GGSRIPPEVD DPSSWYKLLG
GPVDWGYTSV PQPGLDGRRT YEPRGKAPGG SSNLYIMMHI RGHASDFDNW AYQGAAGWAY
EDVLPYFALL EGQEDATAAT TGTRGPQRIT HAGRHGPNPV SRAFIDAAVE LGHEEIEDFN
TDGPRRGLFG TGWHHIDVAD GRRQGTLAAY LEPALERSNL TLRTSAQTTR LLFDGDTCTG
VEYAQLAPPA GFPGRTVGDT AGEPGQHTVR ARREVIVAAG AIESPKLLLL SGIGQPAQLR
EHGIELTAAL PGVGENFHNH VLTGLMAEVT QELPPPAQNL SESALFLSSR PGLPAPDLQI
AFVHVPFDVI VGQDHPNTVS ILPGVVRPVS RGWIRLASAD PLAHPLIHPN YLGDRWDLER
MVQGVKTARE LFATSAFSPW YKQELQPGPG HVTDDELRTF VKQKSESYHH QSGSCRMGVD
DLSVVDPELR VHGVRNLRVV DASVMPAVPS GNCHTAIAMI AERAADFLRG TSRA
//
