ID   B4VVC4_9CYAN            Unreviewed;       704 AA.
AC   B4VVC4;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   RecName: Full=DNA polymerase I {ECO:0000256|ARBA:ARBA00020311};
GN   ORFNames=MC7420_4231 {ECO:0000313|EMBL:EDX74246.1};
OS   Coleofasciculus chthonoplastes PCC 7420.
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Coleofasciculales;
OC   Coleofasciculaceae; Coleofasciculus.
OX   NCBI_TaxID=118168 {ECO:0000313|EMBL:EDX74246.1, ECO:0000313|Proteomes:UP000003835};
RN   [1] {ECO:0000313|EMBL:EDX74246.1, ECO:0000313|Proteomes:UP000003835}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7420 {ECO:0000313|EMBL:EDX74246.1,
RC   ECO:0000313|Proteomes:UP000003835};
RA   Tandeau de Marsac N., Ferriera S., Johnson J., Kravitz S., Beeson K.,
RA   Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL   Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC       {ECO:0000256|ARBA:ARBA00007705}.
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DR   EMBL; DS989854; EDX74246.1; -; Genomic_DNA.
DR   RefSeq; WP_006102551.1; NZ_DS989854.1.
DR   AlphaFoldDB; B4VVC4; -.
DR   STRING; 118168.MC7420_4231; -.
DR   eggNOG; COG0749; Bacteria.
DR   HOGENOM; CLU_391680_0_0_3; -.
DR   OrthoDB; 500893at2; -.
DR   Proteomes; UP000003835; Unassembled WGS sequence.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR   Gene3D; 3.30.70.370; -; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR002298; DNA_polymerase_A.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR   PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR   Pfam; PF00476; DNA_pol_A; 1.
DR   Pfam; PF01612; DNA_pol_A_exo1; 1.
DR   SMART; SM00474; 35EXOc; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   3: Inferred from homology;
KW   Exonuclease {ECO:0000313|EMBL:EDX74246.1};
KW   Hydrolase {ECO:0000313|EMBL:EDX74246.1};
KW   Nuclease {ECO:0000313|EMBL:EDX74246.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003835}.
FT   DOMAIN          20..225
FT                   /note="3'-5' exonuclease"
FT                   /evidence="ECO:0000259|SMART:SM00474"
FT   REGION          363..382
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   704 AA;  79617 MW;  51603CC89D6BF6CA CRC64;
     MTQFYQYKLN LFPEASRQDN IIGLENQGLN QAIGLFQQSP RFGFDLETFS RASTPAIAPE
     TGEIRLIQIA IEQPAVQVIV IDLGWTAKER SRIHQKLESL GFWTTLQERL ANPQVEVVGH
     SLDFEQRWML AKYNFPIRNL RDTKLMSQVY WAGLDPWLLK QHGKPHSLES VCLRLGISID
     KSRQTSDWGW GDLGNGQLSN NQFNYAANDA SITIKVHDLL EPRLKEIGVW TSYLIECAAS
     PAFAQMSHYG MPVDEGVLAD VTVAYEAAYQ SLVEQLGGTF SECLPHLYSP KKLIALINRR
     FRVTLKSANV DDLSKLWGIP EVRLISVIKT TKTYVDYLHS IQAQVRNGFV RGKYTQINRK
     GFGRSSCSEP NLQNPPSPTT FPPELTPYNL PPIRSVFRTH SGCIGVWCDA SKLHARVATQ
     ASLDPELIAR FNSPHGDIFC TIAEKLSQLE GMGSDWTEEN IRRWTLDKHH ANYAQASRLR
     AMSKSVHYGS QNLQGWRTLQ KTIRTKSGIV LSDESAKNSI KAWRQTYKVL ASFQHSIVEK
     ANHDLPSVLG MHLIQSRSKF GLGYVRCLTG RGVFLPKWRQ NVEDGREPKI EGKWKKFNGL
     YSTLVSVKSP DANAAYWTMC EADIIKTFLA YCVAAFDAYP EWEAWVGNCC HDEADIFGKE
     EFGVEIASAV QMAMERAMRI VIKDIPVSED ECPERLLGNC WTDK
//