ID B4WIE0_SYNS7 Unreviewed; 601 AA.
AC B4WIE0;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=GTP-binding protein LepA {ECO:0000313|EMBL:EDX86124.1};
GN ORFNames=S7335_3827 {ECO:0000313|EMBL:EDX86124.1};
OS Synechococcus sp. (strain ATCC 29403 / PCC 7335).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales; Synechococcaceae;
OC Synechococcus.
OX NCBI_TaxID=91464 {ECO:0000313|EMBL:EDX86124.1, ECO:0000313|Proteomes:UP000005766};
RN [1] {ECO:0000313|EMBL:EDX86124.1, ECO:0000313|Proteomes:UP000005766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29403 / PCC 7335 {ECO:0000313|Proteomes:UP000005766};
RA Tandeau de Marsac N., Ferriera S., Johnson J., Kravitz S., Beeson K.,
RA Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. LepA subfamily.
CC {ECO:0000256|ARBA:ARBA00005454}.
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DR EMBL; DS989904; EDX86124.1; -; Genomic_DNA.
DR RefSeq; WP_006455883.1; NZ_DS989904.1.
DR AlphaFoldDB; B4WIE0; -.
DR STRING; 91464.S7335_3827; -.
DR eggNOG; COG0481; Bacteria.
DR HOGENOM; CLU_009995_3_3_3; -.
DR OrthoDB; 580826at2; -.
DR Proteomes; UP000005766; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR CDD; cd03699; EF4_II; 1.
DR CDD; cd16260; EF4_III; 1.
DR CDD; cd01890; LepA; 1.
DR CDD; cd03709; lepA_C; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.2570; Elongation factor 4, C-terminal domain; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR HAMAP; MF_03138; GUFP; 1.
DR HAMAP; MF_00071; LepA; 1.
DR InterPro; IPR006297; EF-4.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027518; GUFP.
DR InterPro; IPR038363; LepA_C_sf.
DR InterPro; IPR013842; LepA_CTD.
DR InterPro; IPR035654; LepA_IV.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR NCBIfam; TIGR01393; lepA; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43512:SF4; TRANSLATION FACTOR GUF1 HOMOLOG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR43512; TRANSLATION FACTOR GUF1-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF06421; LepA_C; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SMART; SM00838; EFG_C; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00022519};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005766}.
FT DOMAIN 7..189
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 601 AA; 67144 MW; 82D41CA008A9F3F5 CRC64;
MTDVPVSRLR NFSIIAHIDH GKSTLADRLL QETGTVSARD MKAQFLDSMD IERERGITIK
LQAARMRYTA KDGEQYVLNL IDTPGHVDFT YEVSRSLAAC EGALLVVDAS QGVEAQTLAN
VYLAIENDLE VIPVLNKVDL PGADPERVKQ EIEEVVGLDC SNAVMASAKE GIGITEILES
ITYLVPSPAD NTQAPVRALI FDSYYDSYRG VIVYFRVMDG AIRSRDRIRL MASGKEYDID
ELGVLSPNQV PVDELHAGEV GYIAASIKSV EDARVGDTIT LVKTPAEEPL AGYIEAKPMV
FCGLFPTDSD QYEDLREALD KLRLNDAALQ YEPETSSAMG FGFRCGFLGL LHMEIVQERL
EREYNLDLIT TAPSVIYRVY TVQGEVIEVD NPSLLPEPQY REKIEEPYVK VDIITPEEFV
GTLMELCQTR RGDFQDMKYL TPGRTTLVYE LPLAEVVTDF FDQMKSRSRG YASMEYQLIG
YRENNLVKLD VKINGDTVDP LAAIVHRDKA YYVGRALTEK LKELIPRHQF KIPVQASIGS
RIIASESIPA LRKDVLAKCY GGDISRKKKL LKKQAKGKKR LKSIGTVDVP QEAFMAVLKL
T
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