ID   B4WK28_SYNS7            Unreviewed;       461 AA.
AC   B4WK28;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   24-JAN-2024, entry version 52.
DE   RecName: Full=isochorismate synthase {ECO:0000256|ARBA:ARBA00012824};
DE            EC=5.4.4.2 {ECO:0000256|ARBA:ARBA00012824};
DE   AltName: Full=Isochorismate mutase {ECO:0000256|ARBA:ARBA00041564};
GN   ORFNames=S7335_5209 {ECO:0000313|EMBL:EDX87499.1};
OS   Synechococcus sp. (strain ATCC 29403 / PCC 7335).
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales; Synechococcaceae;
OC   Synechococcus.
OX   NCBI_TaxID=91464 {ECO:0000313|EMBL:EDX87499.1, ECO:0000313|Proteomes:UP000005766};
RN   [1] {ECO:0000313|EMBL:EDX87499.1, ECO:0000313|Proteomes:UP000005766}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29403 / PCC 7335 {ECO:0000313|Proteomes:UP000005766};
RA   Tandeau de Marsac N., Ferriera S., Johnson J., Kravitz S., Beeson K.,
RA   Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL   Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=chorismate = isochorismate; Xref=Rhea:RHEA:18985,
CC         ChEBI:CHEBI:29748, ChEBI:CHEBI:29780; EC=5.4.4.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00000799};
CC   -!- SIMILARITY: Belongs to the isochorismate synthase family.
CC       {ECO:0000256|ARBA:ARBA00005297}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS989904; EDX87499.1; -; Genomic_DNA.
DR   RefSeq; WP_006457317.1; NZ_DS989904.1.
DR   AlphaFoldDB; B4WK28; -.
DR   STRING; 91464.S7335_5209; -.
DR   eggNOG; COG1169; Bacteria.
DR   HOGENOM; CLU_006493_8_6_3; -.
DR   Proteomes; UP000005766; Unassembled WGS sequence.
DR   GO; GO:0008909; F:isochorismate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR   InterPro; IPR005801; ADC_synthase.
DR   InterPro; IPR015890; Chorismate_C.
DR   InterPro; IPR004561; IsoChor_synthase.
DR   NCBIfam; TIGR00543; isochor_syn; 1.
DR   PANTHER; PTHR42839; ISOCHORISMATE SYNTHASE ENTC; 1.
DR   PANTHER; PTHR42839:SF2; ISOCHORISMATE SYNTHASE ENTC; 1.
DR   Pfam; PF00425; Chorismate_bind; 1.
DR   SUPFAM; SSF56322; ADC synthase; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:EDX87499.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005766}.
FT   DOMAIN          230..443
FT                   /note="Chorismate-utilising enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00425"
SQ   SEQUENCE   461 AA;  50521 MW;  CE432D91B7C93AFA CRC64;
     MKNTAQKIFP NQPQSQSQSQ LNSATALLEA SDHETSFFLA TPHQTMLAQG IRDILPAQKG
     ALAYPDLPKQ AVALFDRQSQ RGLSKLPLVG AIPFDDSANV HLFMPDRLHR AGPLRNDRNM
     SVAPKPKASA SNACRLQMLP EPASYMEGVE QALEYIQQSE LLKIVLSRSL ELSFAQMPHL
     GELLNGLARS NRYGYTYLVN LARCQQSAPK QSFISEKQLA SEKTLAPEKQ SAFVKQLDSK
     NTHSFLQHSR HHLVGASPEL LVRRRGMQVE ANPLAGSAPR SGDPIIDQQR AEALMNSDKD
     RREHAVVVEA MAEALRPFCH DLAVPPTPDI LQTDSMIHLS TYLQGTLKNS ETCALSLALA
     LHPTPAICGA PTQCAYSAIH AIEPFARRYF TGLVGWVDSQ GDGEWAVTIR CGEAEGRHLR
     LYAGAGIVAG STAAKELAET SAKFRTMLKA LDLEHLLEAR L
//