ID B4YB46_MOUSE Unreviewed; 312 AA.
AC B4YB46; E9PVN2;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 127.
DE SubName: Full=Delta like non-canonical Notch ligand 1 {ECO:0000313|Ensembl:ENSMUSP00000105468.3};
DE SubName: Full=Dlk1 {ECO:0000313|EMBL:ACF20048.1};
GN Name=Dlk1 {ECO:0000313|Ensembl:ENSMUSP00000105468.3,
GN ECO:0000313|MGI:MGI:94900};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:ACF20048.1};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000105468.3, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000105468.3,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|EMBL:ACF20048.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Swiss Webster {ECO:0000313|EMBL:ACF20048.1};
RX PubMed=19194500; DOI=10.1371/journal.pone.0004352;
RA Hagan J.P., O'Neill B.L., Stewart C.L., Kozlov S.V., Croce C.M.;
RT "At least ten genes define the imprinted Dlk1-Dio3 cluster on mouse
RT chromosome 12qF1.";
RL PLoS ONE 4:E4352-E4352(2009).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000105468.3}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000105468.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; EU434915; ACF20048.1; -; mRNA.
DR RefSeq; NP_001177633.1; NM_001190704.1.
DR ProteomicsDB; 336587; -.
DR Antibodypedia; 27564; 664 antibodies from 40 providers.
DR DNASU; 13386; -.
DR Ensembl; ENSMUST00000109842.9; ENSMUSP00000105468.3; ENSMUSG00000040856.18.
DR GeneID; 13386; -.
DR UCSC; uc011yrz.1; mouse.
DR AGR; MGI:94900; -.
DR CTD; 8788; -.
DR MGI; MGI:94900; Dlk1.
DR VEuPathDB; HostDB:ENSMUSG00000040856; -.
DR GeneTree; ENSGT00940000154225; -.
DR OrthoDB; 5475408at2759; -.
DR BioGRID-ORCS; 13386; 1 hit in 78 CRISPR screens.
DR ChiTaRS; Dlk1; mouse.
DR Proteomes; UP000000589; Chromosome 12.
DR Bgee; ENSMUSG00000040856; Expressed in yolk sac and 123 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR PANTHER; PTHR24052; DELTA-RELATED; 1.
DR PANTHER; PTHR24052:SF8; NIMROD A, ISOFORM E; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF00008; EGF; 3.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 4.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|ProteomicsDB:B4YB46};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..312
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015087314"
FT TRANSMEM 236..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 22..55
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 88..125
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 127..168
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 172..208
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 45..54
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 115..124
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 158..167
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 198..207
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 312 AA; 33289 MW; 9A374DE185663CC4 CRC64;
MIATGALLRV LLLLLAFGHS TYGAECDPPC DPQYGFCEAD NVCRCHVGWE GPLCDKCVTA
PGCVNGVCKE PWQCICKDGW DGKFCEIDVR ACTSTPCANN GTCVDLEKGQ YECSCTPGFS
GKDCQHKAGP CVINGSPCQH GGACVDDEGQ ASHASCLCPP GFSGNFCEIV AATNSCTPNP
CENDGVCTDI GGDFRCRCPA GFVDKTCSRP VSNCASGPCQ NGGTCLQHTQ GQAICFTILG
VLTSLVVLGT VAIVFLNKCE TWVSNLRYNH MLRKKKNLLL QYNSGEELAV NIIFPEKIDM
TTFNKEAGDE EI
//
