ID   B5ACE2_PVT92            Unreviewed;      1606 AA.
AC   B5ACE2;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   08-NOV-2023, entry version 94.
DE   SubName: Full=Replicase {ECO:0000313|EMBL:ACF39932.1};
OS   Potato virus T (isolate Chenopodium amaranticolor/Peru/-/1992) (PVT).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Tymovirales; Betaflexiviridae; Trivirinae; Tepovirus; Potato virus T.
OX   NCBI_TaxID=1289386 {ECO:0000313|EMBL:ACF39932.1, ECO:0000313|Proteomes:UP000011262};
OH   NCBI_TaxID=50475; Oxalis tuberosa (Oca).
OH   NCBI_TaxID=50514; Solanum demissum (Wild potato).
OH   NCBI_TaxID=4113; Solanum tuberosum (Potato).
OH   NCBI_TaxID=147035; Tropaeolum tuberosum.
OH   NCBI_TaxID=108055; Ullucus tuberosus (Olluco).
RN   [1] {ECO:0000313|EMBL:ACF39932.1, ECO:0000313|Proteomes:UP000011262}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate Chenopodium amaranticolor/Peru/-/1992
RC   {ECO:0000313|Proteomes:UP000011262};
RA   Russo M., Rubino L., Martelli G.P.;
RT   "Sequence analysis of the Potato virus T genome.";
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; EU835937; ACF39932.1; -; Genomic_RNA.
DR   RefSeq; YP_002019748.1; NC_011062.1.
DR   GeneID; 10987370; -.
DR   KEGG; vg:10987370; -.
DR   Proteomes; UP000011262; Segment.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008174; F:mRNA methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027351; (+)RNA_virus_helicase_core_dom.
DR   InterPro; IPR002588; Alphavirus-like_MT_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001788; RNA-dep_RNA_pol_alsuvir.
DR   InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR   Pfam; PF00978; RdRP_2; 1.
DR   Pfam; PF01443; Viral_helicase1; 1.
DR   Pfam; PF01660; Vmethyltransf; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51743; ALPHAVIRUS_MT; 1.
DR   PROSITE; PS51657; PSRV_HELICASE; 1.
DR   PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011262};
KW   RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT   DOMAIN          63..232
FT                   /note="Alphavirus-like MT"
FT                   /evidence="ECO:0000259|PROSITE:PS51743"
FT   DOMAIN          768..1069
FT                   /note="(+)RNA virus helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51657"
FT   DOMAIN          1362..1469
FT                   /note="RdRp catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50507"
FT   REGION          574..597
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1606 AA;  184826 MW;  4B7E66D47F3C3A33 CRC64;
     MSFSFRTPAE LFVQSLPKEY AEACFKSHAA NFQIRSDKGV GLFDFACSSV VKERLTKAGI
     PVSAFCNQEH SHPASKMIEN HLLYNILPNY LNLKNYTAIS IKDSKVRKLL KNGVDSLETF
     NRLFSCKDAL RYVDPETCDM DKFIARVHHS TRIFLFDELH YWSMNSLSDF LDRSNVKELL
     ATIVFPIEIL LGSKRSLNPE LYEFEISRGK LHFFPDGCTS ESYSQPKDCD ILKVNRIVTK
     TGKIFSVELI HTIGANHMVM IKEGSFDVDS ERFFDRSSAL TTSLLMPTRA GKALRIRRKF
     LLRLIIYLFS LKKPDHHSAI AKIRQSSDDS IFCDEIMLAD HVGKIFEKLD PASPFGVKGV
     FDLLTSIFKD IFLLDGLFNW SDRRKSEKFV EFMRALDYQT NKVVTCTFSG GVMRSGFLAE
     FFLDNDCEAS EGLDEVISRF DTFFDPKKEY SAHALRVNIK DRTPNPYGPM KARTPSVVLH
     REYITKVEFS SKAKKVNVLK ERLTGEVSFE EARLQRMRYS DSQFVAGLAP KLRYVKMLTW
     KKDQKLFSEF PSEESNEVEM EDAFELRKGR TLKRGTKERD EDGANSEECE QLDSEDDVGS
     FDYEETKADS YEIDFEAILN RVNSGGLRGV CLLDALAKIT GTKREITLSI LLGRDGTWAD
     WFLKDKGATF DDVFKAVSDL DLNCTICTKE GSFNAHVNRN YKHNFLYLFD EHVSLERPKV
     MLFEQVRHQK IDFLGAFEKC PGAGKFRYEA LAERGSLLAS ALKDNLTGVI SSKFNWDPKC
     EFVDIEKEIL VVAGFAGSGK TRGICQIVKS MFNNKKTLVL SPRKNLADDW VKNLANLHRP
     SHVKVMTFEA GLRRVQKSSL IVIDELSLMP NGYLDMLINM NEEATFITLF DPLQARYHAK
     SDVLRVSPEN DVDRIKVPKY LFFSKRMSSE LDFFDVRCSS DQKKWELHGK QYREPAALFR
     DIKGQEFTIL SPSFETAREM SKYADIKDGC KSMTFGESQG LTVNKAVIVV DQDLVATSVL
     HWIVALTRSR QGFVILVHKV FDMKTLIQPV QNSIIGLVLR GVKVQENIFI NTAGKCLSEA
     EIVEELETFK RTEEDEDLLE GDPWLKGQLF LCQSVELDEV TPEEPLRHES PPRTHLPLPV
     EGLTPLLMSN VKAREDREFI TPSGWSKQFR DDKENVDWRN VSYADAFETI YPKHEASDDI
     TLWAAIQKRI VMADPFRNAM KLQKVEPISA EIFNEMNKIL LLNPHVSVDR DQVYKEFLRK
     RLNKSKKLIE SHSERSSDDW PIDHFFLFMK SQLCTKFEKR FVDAKAGQTL ACFSHKLLTR
     FGPAFREFEK KFTANLPPSW YIHTMKNFDQ LNNWVINYVD QEEGTESDYE AFDRSQDAII
     LGLEIECLKL FGWDQDLIDD YRKLKLRMGC RWGAIAIMRF TGEFGTFFFN TIANIAFTCL
     RYNITRDTVI AFAGDDMYAS GKLEIRKDRE DLLAHLTLKA KVQFTEKPMF CGWYIKKMGI
     VKEPRLVLER WLIAERKKVI DQCFINYSIE VSYGYRLGEY LWEYFDNLED FQAIVRLVIK
     KKKQLPPAIR RIFETSNGVD FSGEVQETMG GEGEHHGSCG LWCNLH
//