ID   B5CRW7_9FIRM            Unreviewed;       661 AA.
AC   B5CRW7;
DT   14-OCT-2008, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2008, sequence version 1.
DT   27-MAR-2024, entry version 58.
DE   SubName: Full=Putative DNA-directed DNA polymerase {ECO:0000313|EMBL:EDY32055.1};
GN   ORFNames=RUMLAC_02218 {ECO:0000313|EMBL:EDY32055.1};
OS   [Ruminococcus] lactaris ATCC 29176.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Mediterraneibacter.
OX   NCBI_TaxID=471875 {ECO:0000313|EMBL:EDY32055.1, ECO:0000313|Proteomes:UP000003254};
RN   [1] {ECO:0000313|EMBL:EDY32055.1, ECO:0000313|Proteomes:UP000003254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29176 {ECO:0000313|EMBL:EDY32055.1,
RC   ECO:0000313|Proteomes:UP000003254};
RA   Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M., Liep D.,
RA   Gordon J.;
RT   "Draft genome sequence of Ruminococcus lactaris ATCC 29176.";
RL   Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EDY32055.1, ECO:0000313|Proteomes:UP000003254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29176 {ECO:0000313|EMBL:EDY32055.1,
RC   ECO:0000313|Proteomes:UP000003254};
RA   Fulton L., Clifton S., Fulton B., Xu J., Minx P., Pepin K.H., Johnson M.,
RA   Bhonagiri V., Nash W.E., Mardis E.R., Wilson R.K.;
RL   Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC       {ECO:0000256|ARBA:ARBA00007705}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EDY32055.1}.
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DR   EMBL; ABOU02000048; EDY32055.1; -; Genomic_DNA.
DR   AlphaFoldDB; B5CRW7; -.
DR   eggNOG; COG0749; Bacteria.
DR   HOGENOM; CLU_012044_0_0_9; -.
DR   Proteomes; UP000003254; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR   CDD; cd08642; DNA_pol_A_pol_I_A; 1.
DR   Gene3D; 3.30.70.370; -; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR002298; DNA_polymerase_A.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR   PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR   Pfam; PF00476; DNA_pol_A; 1.
DR   PRINTS; PR00868; DNAPOLI.
DR   SMART; SM00482; POLAc; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   3: Inferred from homology;
KW   DNA-directed DNA polymerase {ECO:0000313|EMBL:EDY32055.1};
KW   Nucleotidyltransferase {ECO:0000313|EMBL:EDY32055.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003254};
KW   Transferase {ECO:0000313|EMBL:EDY32055.1}.
FT   DOMAIN          385..627
FT                   /note="DNA-directed DNA polymerase family A palm"
FT                   /evidence="ECO:0000259|SMART:SM00482"
SQ   SEQUENCE   661 AA;  74465 MW;  082CB59AC373D21F CRC64;
     MMKELSIDLE TYSDIDISKC GAYKYAESNN FEILLFGVSV DNGPVVVYDL ASGDEIPAEI
     LAALSDENII KWAFNASFER VCLSNWLRKH HPEYFKTYNT QGDPVQNFLD PASWKCTMIW
     SAYMGLPLSL EGVGAVLKLQ DQKMKEGKDL IKYFCSPCKP TKVNGGRTRN LPEHAPDKWE
     TFKTYNRRDV EVELAIKQRL SKFPVPDSVW HEYHIDQEIN DSGIMLDMDV VENAIAFDER
     SKSALITAMK NITNLDNPNS VVQMKQWLSD NGVETESLGK KEVAGLIKET DGDISKALKL
     RLQLAKSSVK KYQAMQNAVC KDGRAHGMFQ FYGANRSGRW AGRLIQLQNL PQNHMSDLTE
     ARELVRTGDY DTLDMLYDDI PDTLSQLIRT AFIARPGYKF IVSDYSAIEA RVLAHLAGET
     WRSKVFAEGK DIYCASASQM FGVPVKKHGI NSHLRQKGKI AELALGYGGS VGALKSMGAL
     EMGLTEEELQ PLVDSWRSSN PMITAFWWNV DNAIKTAIKM HIPTEVNGIH FCYKSGMLLI
     KRPSGRVLSY VKPKIGENRF GGESVTYEGI GSTKKWERIE SYGPKFVENI VQAVSRDILC
     NAMKTLRHCF IVGHVHDELI IECSSGVDLN EICKQMGRSL DWMPGILLRA DGYETNFYKK
     E
//