ID   B5DQP9_DROPS            Unreviewed;       686 AA.
AC   B5DQP9; A0A6I8VJU0;
DT   14-OCT-2008, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2008, sequence version 1.
DT   27-MAR-2024, entry version 92.
DE   SubName: Full=Ras-GEF domain-containing family member 1B-B {ECO:0000313|RefSeq:XP_015042780.1};
GN   Name=LOC6900452 {ECO:0000313|RefSeq:XP_015042780.1};
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245 {ECO:0000313|Proteomes:UP000001819, ECO:0000313|RefSeq:XP_015042780.1};
RN   [1] {ECO:0000313|RefSeq:XP_015042780.1}
RP   IDENTIFICATION.
RC   STRAIN=MV2-25 {ECO:0000313|RefSeq:XP_015042780.1};
RC   TISSUE=Whole body {ECO:0000313|RefSeq:XP_015042780.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_002134845.1; XM_002134809.2.
DR   RefSeq; XP_015042780.1; XM_015187294.2.
DR   AlphaFoldDB; B5DQP9; -.
DR   EnsemblMetazoa; FBtr0276174; FBpp0274612; FBgn0244983.
DR   EnsemblMetazoa; FBtr0368448; FBpp0331215; FBgn0244983.
DR   GeneID; 6900452; -.
DR   KEGG; dpo:6900452; -.
DR   eggNOG; KOG3541; Eukaryota.
DR   HOGENOM; CLU_022907_1_0_1; -.
DR   InParanoid; B5DQP9; -.
DR   OMA; ISQTWEH; -.
DR   Proteomes; UP000001819; Chromosome X.
DR   Bgee; FBgn0244983; Expressed in insect adult head and 2 other cell types or tissues.
DR   ExpressionAtlas; B5DQP9; baseline.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113:SF356; FI05912P-RELATED; 1.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001819}.
SQ   SEQUENCE   686 AA;  75929 MW;  5F15F7493E2F660C CRC64;
     MSSSNGGINS ATNGRSGSTG SANISLNIKG TAAGGAAAAS TSATTTSITH KTLPDLKTQR
     SNSVCHSQET YSGNRRVAPT EKPPEKPLSY APAQSRATGK EPKEGHLVYC EGKLHSGPLK
     SLITHMVPTH EYYPDESFVF AFLLSARLFV RPHELLAQIS TTWEQQQGAG GGCDVVDDAG
     QVLNLSINSA SPLTQRKGAA AAAAIATATS SELEPKPQQR TSTQRSAQHC IRLLSEWIEI
     FPYDFRDERL MQQVRILARK CVYIDNSLGK QVSRILQLLV SRLTALEQYE EFLLTLTTEA
     SEREVVAVAS GQSQHHHNHH HHHLHNPFQT FLGSSHSHAN GVGGGGSASG TSNSSSSGNT
     SSSTSNSNST TPQPDEVFGI MDMCPSCAHL AHQLTAIELE RLSHIGPEEF VQAFAKDYPQ
     QQAKDGAGGG GAGKGSLNDM KKTRNLESYV QWFNRLSYLT ASEIVKYPKK KQRVRIIEYW
     IETARECFNI GNFNSLMAII AGLNLAPIGR LKKTWSKVQS AKFSVLEHQM DPTSNFNSYR
     STLKAAMWRS EGATEERERI IIPFFSLFVK DLYFLNEGCS NRLPNNHINF EKCSQLAKQV
     TEFNEWKKVT CPFEKLPNVI AYLQHSAVLN ENTLSMASFE CEPPENTEEK DRYKTVKAET
     KQQLLQQLQE QQHQQHQLHQ HHHQSQ
//