ID MUTL_ALIFM Reviewed; 661 AA.
AC B5FBR6;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=VFMJ11_2438;
OS Aliivibrio fischeri (strain MJ11) (Vibrio fischeri).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Aliivibrio.
OX NCBI_TaxID=388396;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MJ11;
RA Mandel M.J., Stabb E.V., Ruby E.G., Ferriera S., Johnson J., Kravitz S.,
RA Beeson K., Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RT "Complete sequence of Vibrio fischeri strain MJ11.";
RL Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; CP001139; ACH65712.1; -; Genomic_DNA.
DR RefSeq; WP_012533237.1; NC_011184.1.
DR AlphaFoldDB; B5FBR6; -.
DR SMR; B5FBR6; -.
DR GeneID; 77253570; -.
DR KEGG; vfm:VFMJ11_2438; -.
DR HOGENOM; CLU_004131_5_1_6; -.
DR Proteomes; UP000001857; Chromosome I.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03482; MutL_Trans_MutL; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair.
FT CHAIN 1..661
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_1000096699"
FT REGION 367..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 661 AA; 74145 MW; 23AAA8AB08731285 CRC64;
MPIQILPARL ANQIAAGEVV ERPASVVKEL VENSIDAGAT RIDIDIEKGG SKLIRIRDNG
SGIPKDELTL ALSRHATSKI TSLDDLEAIV SLGFRGEALA SISSVSRLTL TSRTVAQEEA
WSAYAEGREM NVKLKPAAHP IGTTIDVVDL FFNTPARRKF LRADKTEFTH IDELLKRIAL
SRLDVTINLR HNGKMVRQYR AAQTKPQIEK RLAAVCGANF LQHALEVELE HGELKFHGWI
SSPEGARAQG DIQYCYVNGR MMKDKLINHA IRQGYESSLP ANQYAAYILF IEINPHDVDV
NVHPAKHEVR FHQARLVHDF IYQAIFGALQ QGASLSNVVC NDQPLVEEQV IENKESYFPP
MKEYVRQPQQ SHYPKSEQLR VAVESTPSYP NKAPLDSWIP KSSTGNSSSK PSALPRSFHN
NDKPAEKALS NYNELLTTQS RVQRESSSQV NEQSLTFSTT QQIERVAPQV THVSKNDITL
GKVLSVVEST FALLQQGKQL QLLNLRYAEF VKTYGQLSSV NVEPLKPQPL LIPLSVGIDE
SICNNLSNYA SLLKSLGIDL KVKNRTNIIV MAVCQPIRQQ NLQQLIPNLL RYLEQINPSL
EQVIKWLSHQ IQHDEVSYTT AQAIQLVMEL EQLWGGKLND FYPKLLKDID ITQVIQAFSH
E
//
