ID B5H9Y9_STRE2 Unreviewed; 719 AA.
AC B5H9Y9;
DT 14-OCT-2008, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2008, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Peptidase {ECO:0000313|EMBL:EDY63650.1};
GN ORFNames=SSDG_01864 {ECO:0000313|EMBL:EDY63650.1};
OS Streptomyces pristinaespiralis (strain ATCC 25486 / DSM 40338 / CBS 914.69
OS / JCM 4507 / NBRC 13074 / NRRL 2958 / 5647).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=457429 {ECO:0000313|EMBL:EDY63650.1, ECO:0000313|Proteomes:UP000002805};
RN [1] {ECO:0000313|Proteomes:UP000002805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25486 / DSM 40338 / CBS 914.69 / JCM 4507 / NBRC 13074 /
RC NRRL 2958 / 5647 {ECO:0000313|Proteomes:UP000002805};
RG The Broad Institute Genome Sequencing Platform;
RA Fischbach M., Ward D., Young S., Jaffe D., Gnerre S., Berlin A., Heiman D.,
RA Hepburn T., Sykes S., Alvarado L., Kodira C.D., Straight P., Clardy J.,
RA Hung D., Kolter R., Mekalanos J., Walker S., Walsh C.T., Lander E.,
RA Galagan J., Nusbaum C., Birren B.;
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25486 / DSM 40338 / CBS 914.69 / JCM 4507 / NBRC 13074 /
RC NRRL 2958 / 5647 {ECO:0000313|Proteomes:UP000002805};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Microbial Sequencing Center;
RA Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA Thomson T., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Streptomyces pristinaespiralis strain ATCC 25486.";
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CM000950; EDY63650.1; -; Genomic_DNA.
DR RefSeq; WP_005312425.1; NZ_CM000950.1.
DR AlphaFoldDB; B5H9Y9; -.
DR ESTHER; strpr-b5h9y9; DPP4N_Peptidase_S9.
DR eggNOG; COG1506; Bacteria.
DR HOGENOM; CLU_006105_2_1_11; -.
DR Proteomes; UP000002805; Chromosome.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR011659; PD40.
DR InterPro; IPR002471; Pept_S9_AS.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002470; Peptidase_S9A.
DR InterPro; IPR002469; Peptidase_S9B_N.
DR PANTHER; PTHR11731:SF193; DIPEPTIDYL PEPTIDASE 9; 1.
DR PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR Pfam; PF00930; DPPIV_N; 1.
DR Pfam; PF07676; PD40; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR PRINTS; PR00862; PROLIGOPTASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000002805}.
FT DOMAIN 116..327
FT /note="Dipeptidylpeptidase IV N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00930"
FT DOMAIN 516..717
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 719 AA; 77130 MW; 4D5B69800AFAEF14 CRC64;
MTSTQPLSFP RQSARTQRFT LGAPRAFTVS PDGSRVVFLR SSSGTDRSGL LWVLDLEGHG
PPQERPAADP RELLGGIAEE LSAEERARRE RSREGSAGIV AYAVDRAVEL AAFTLSGRLF
TAELRAGTAR ELPTPGPVLD PRPSPDGRLV AYVAGGALRV TGAEGEEDRA LAEPEDEHTT
YGLAEFIAAE EMGRSRGFWW SPDSDRLLVA RADERDVRRW WIPDPAQPDQ EPSKVAYPAA
GTPNATVRLF FVALDGNRTE VTWDRERYPY LARVHWSAAG PPLLLVQSRD QRTQLYLAVD
PESGSTRTVH VDEDEAWLEL FSGVPAWAPE SSYEQGFGGG RLVRIADEGG ARVLAVGDRV
LTGAQLQLRA VLDIGESDVL VSAAAGADSA EPETGEIHVY RVNELGVERV SDGPGVHAAV
RGGGVTVLAS SRTDVSGALV QVLRDGKQVA VVASHAEEPV LRARPTLTEA GARRIPCAVL
LPSGHRDADG PLPVLMDPYG GPHGQRVLAA HNPYLTSQWF ADQGFAVVVA DGRGTPGRSP
GWEKAVVGDF TPTLDDQIEA LQSLAGSFPL DLDRVAIRGW SYGGYLAAMA VLRRPDVFHA
AVAGAPVTDW RLYDTHYTER YLGDPAAQSA AYAANSLVTD AGLTSAEGPA RPLMIVHGLA
DDNVVMAHTL RLSSALLAAG RAHEVLPLTG VTHMTPQEQI AENLLLLQVD FLKRSLGRA
//
