ID B5HBY3_STRE2 Unreviewed; 993 AA.
AC B5HBY3;
DT 14-OCT-2008, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2008, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Transcriptional regulator {ECO:0000313|EMBL:EDY64344.1};
GN ORFNames=SSDG_02666 {ECO:0000313|EMBL:EDY64344.1};
OS Streptomyces pristinaespiralis (strain ATCC 25486 / DSM 40338 / CBS 914.69
OS / JCM 4507 / NBRC 13074 / NRRL 2958 / 5647).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=457429 {ECO:0000313|EMBL:EDY64344.1, ECO:0000313|Proteomes:UP000002805};
RN [1] {ECO:0000313|Proteomes:UP000002805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25486 / DSM 40338 / CBS 914.69 / JCM 4507 / NBRC 13074 /
RC NRRL 2958 / 5647 {ECO:0000313|Proteomes:UP000002805};
RG The Broad Institute Genome Sequencing Platform;
RA Fischbach M., Ward D., Young S., Jaffe D., Gnerre S., Berlin A., Heiman D.,
RA Hepburn T., Sykes S., Alvarado L., Kodira C.D., Straight P., Clardy J.,
RA Hung D., Kolter R., Mekalanos J., Walker S., Walsh C.T., Lander E.,
RA Galagan J., Nusbaum C., Birren B.;
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25486 / DSM 40338 / CBS 914.69 / JCM 4507 / NBRC 13074 /
RC NRRL 2958 / 5647 {ECO:0000313|Proteomes:UP000002805};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Microbial Sequencing Center;
RA Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA Thomson T., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Streptomyces pristinaespiralis strain ATCC 25486.";
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC {ECO:0000256|ARBA:ARBA00005820}.
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DR EMBL; CM000950; EDY64344.1; -; Genomic_DNA.
DR AlphaFoldDB; B5HBY3; -.
DR eggNOG; COG3629; Bacteria.
DR eggNOG; COG3903; Bacteria.
DR HOGENOM; CLU_004665_2_0_11; -.
DR Proteomes; UP000002805; Chromosome.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0098542; P:defense response to other organism; IEA:UniProt.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR005158; BTAD.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR35807:SF1; TRANSCRIPTIONAL REGULATOR REDD; 1.
DR PANTHER; PTHR35807; TRANSCRIPTIONAL REGULATOR REDD-RELATED; 1.
DR Pfam; PF03704; BTAD; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF13424; TPR_12; 2.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00382; AAA; 1.
DR SMART; SM01043; BTAD; 1.
DR SMART; SM00028; TPR; 6.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS51755; OMPR_PHOB; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU01091}; Reference proteome {ECO:0000313|Proteomes:UP000002805};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 27..128
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT DNA_BIND 27..128
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
SQ SEQUENCE 993 AA; 106719 MW; A2FFE7AD0AFEC875 CRC64;
MFDGTSTGTL FGVIRTPVRC AAVADCRGGA RMGDPTFGVL GSLQVRVDGV PVRLGGAKPR
AVLATLLLQP GGFVSLDLLT EVLWPGGAPR SAVANVRTYV RTLRRALSMA GAATDRLRTK
PAGYALDIGP GDLDMLLFEQ RLDRARTVRD QGDDAAALRA YEAALGLWRG GVLQDVPASV
VWDPAVTRLE GLRSAAVDEC LEVRLRLGDH APVIAGLRSR LHDDPLREDL WRMLVHALHD
SGRTAEARAA YAEAERIIAA ELGIEPSEPL RAMGEQVNGY AGRRRSPAPA PVCQLPMDVP
DFTGRADEVA EHERLLSTAG RQPVVAVLSG PPGSGKTTLA VHVAHRVRAA FPDGQLFVDL
GGTSDRPREP ADVLGEMLRG LGVIDSAVPG EPVERAALLR SRLAQRRFLI VLDDAVGSAQ
VRPLLPGTGG SAVLVSSRRR MPGLPAHHSA LGVMRRDDAR ALFGAVVGPD RLHAEAADVD
RVLAACGSLP LAVRIAGARL ANRPGWSVGT LADFLHDERG RLDQLRTGEL EVRASAELSY
RHLPGPAARV FRAFGRLADD AVAGWAVAVA TGHADEAARA LETLLDEHLV EVVGEDRLGQ
QRYRMHDLLR CYARELAEAE GHETRVRRQL RVVEALIGLA RSANAAMPTR FLGVLGEPAP
VTGPASGIAD RVRALPVEWF ESERRILVAA VDSATRLGRV LLAADLAIEL AGFFDMRGYY
GDWLRTHQLV LDAMPDPSDA RAAALLRNLG QLHLYQDRYA EALASFDRSR EIFAGLGHGS
GEAVAALGAG SVYRVVGDLD AALAAFTDAL DGFGEAGDRH GEAVARNAIA SVWLERKDPE
TAAGWLDGAL ELARDLGDRH REAQVRRRIA VLYELRGEPG VARAELERAL GIFDDLADTH
CAAYVQQSIG ELCLRQGDAG QASALLVGAL AVQQQLGDRR AEARVACLLG ELHHATGRKQ
TARRYFHRSL STWRRLDARD QAALVDAKLK SLR
//
