ID B5HE50_STRE2 Unreviewed; 997 AA.
AC B5HE50;
DT 14-OCT-2008, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2008, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Large, multifunctional secreted protein {ECO:0000313|EMBL:EDY65111.1};
GN ORFNames=SSDG_03434 {ECO:0000313|EMBL:EDY65111.1};
OS Streptomyces pristinaespiralis (strain ATCC 25486 / DSM 40338 / CBS 914.69
OS / JCM 4507 / NBRC 13074 / NRRL 2958 / 5647).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=457429 {ECO:0000313|EMBL:EDY65111.1, ECO:0000313|Proteomes:UP000002805};
RN [1] {ECO:0000313|Proteomes:UP000002805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25486 / DSM 40338 / CBS 914.69 / JCM 4507 / NBRC 13074 /
RC NRRL 2958 / 5647 {ECO:0000313|Proteomes:UP000002805};
RG The Broad Institute Genome Sequencing Platform;
RA Fischbach M., Ward D., Young S., Jaffe D., Gnerre S., Berlin A., Heiman D.,
RA Hepburn T., Sykes S., Alvarado L., Kodira C.D., Straight P., Clardy J.,
RA Hung D., Kolter R., Mekalanos J., Walker S., Walsh C.T., Lander E.,
RA Galagan J., Nusbaum C., Birren B.;
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25486 / DSM 40338 / CBS 914.69 / JCM 4507 / NBRC 13074 /
RC NRRL 2958 / 5647 {ECO:0000313|Proteomes:UP000002805};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Microbial Sequencing Center;
RA Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA Thomson T., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Streptomyces pristinaespiralis strain ATCC 25486.";
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CM000950; EDY65111.1; -; Genomic_DNA.
DR RefSeq; WP_005307885.1; NZ_CM000950.1.
DR AlphaFoldDB; B5HE50; -.
DR eggNOG; COG2133; Bacteria.
DR HOGENOM; CLU_302417_0_0_11; -.
DR Proteomes; UP000002805; Chromosome.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR CDD; cd04083; CBM35_Lmo2446-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR Gene3D; 3.90.182.10; Toxin - Anthrax Protective Antigen;domain 1; 1.
DR InterPro; IPR010496; 3-keto-disaccharide_hydrolase.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR006584; Cellulose-bd_IV.
DR InterPro; IPR005084; CMB_fam6.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR037524; PA14/GLEYA.
DR InterPro; IPR011658; PA14_dom.
DR PANTHER; PTHR33546; LARGE, MULTIFUNCTIONAL SECRETED PROTEIN-RELATED; 1.
DR PANTHER; PTHR33546:SF1; LARGE, MULTIFUNCTIONAL SECRETED PROTEIN-RELATED; 1.
DR Pfam; PF06439; 3keto-disac_hyd; 1.
DR Pfam; PF16990; CBM_35; 1.
DR Pfam; PF07691; PA14; 1.
DR SMART; SM00606; CBD_IV; 1.
DR SMART; SM00758; PA14; 1.
DR SUPFAM; SSF56988; Anthrax protective antigen; 1.
DR SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS51175; CBM6; 1.
DR PROSITE; PS51820; PA14; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002805};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..997
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002834636"
FT DOMAIN 43..186
FT /note="PA14"
FT /evidence="ECO:0000259|PROSITE:PS51820"
FT DOMAIN 675..803
FT /note="CBM6"
FT /evidence="ECO:0000259|PROSITE:PS51175"
FT REGION 201..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 997 AA; 107253 MW; CA314B555BAFD6BC CRC64;
MNPRLRQRLR RRTTGLVAAS FLAGCLISPP ASAAAGAAED LPPQEPGVTL RVFDIQLPMS
KICSIKPGQT PNVDKLMPTI DWSSTDDFGV GDNFVSQVIG NIDVPQDGSY TFRLTSDDGS
RLLIDERPVI DHDGLHGAEP KDGTVTLTAG HHALRIDHFD RTGGQQVTLA WRPPGASDFS
VVPNSVLSTD AGVVRVTAPG RKECESGTDS PGDGLPLTGV HPGYDLTDLR PAGFEPQITG
MDWLPDGRLA VTTWGGTDNT AGEVYLLGNV THDTGPDKVT VKKVASGLKE PMGIKAVDGK
IYVSQKHELT ELSDVDGDDV IDERRTVATW PFGGNFHEFA FGLLYRKGFF YLNLSVAINY
GGATTDPQPA RNRGTTVKVN AKTGEVSYVA GGLRTPNGIG WGPGGDIFVT DNQGGWLPAS
KLVRIKQDRF FNHFTNPDGP FDANPVSKPV LWLPQNEIAN SPSTPLHLTT GPYAGQLLFG
DVTYGGLQRA YLEKVKGQDQ GAVFRHTQGL EAGVNRISQG PDGAIYAGGL GAGGNWGQEG
KLTHGLQKLT PNGDDVFDIL AMRAKRNGFE LEYTQPLSQA TADKLAAGYQ VEQWRYVPTP
QYGGPKVDEE KLAVQSAALS ADRKKVTLVI PGLKPDRVVH VRSPRPFSSA SGEALWSTEA
WYTLNAMPGR QPEVTLYEAE EARLAGGAGT DTEHAGHSGS GFVDGYGTEG ASTTFDVNVE
EAGTYDVGLR YANGPHPFTG TKTVSVYVNG TRTGQTQLLS TGEWNKWSTR TEQLPLRAGA
NTISYRYDSG DTGHVNLDMI TVHPHGSRVV LFDGADRSAW QQTDGRTAQW PLTDGAMEVC
CGDIRTKQAF GDFKLHTEFW LPVLPPDVTG QDRANSGVYL QDRYEIQVLD SYGAPPAVDG
AAAIYQRKAA DVNAAKPPGT WQTYDITFRA ARFDEAGRKT QDARVTVVWN GVTVHDDVAV
AGPTGAGAPE GPTAGPIRLQ DHGSKVRYRN IWIEPLS
//
