ID   B5HGU2_STRE2            Unreviewed;       387 AA.
AC   B5HGU2;
DT   14-OCT-2008, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 2.
DT   27-MAR-2024, entry version 47.
DE   RecName: Full=Acetoin utilization protein AcuC {ECO:0000256|ARBA:ARBA00020218};
GN   ORFNames=SSDG_04376 {ECO:0000313|EMBL:EDY66053.2};
OS   Streptomyces pristinaespiralis (strain ATCC 25486 / DSM 40338 / CBS 914.69
OS   / JCM 4507 / NBRC 13074 / NRRL 2958 / 5647).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=457429 {ECO:0000313|EMBL:EDY66053.2, ECO:0000313|Proteomes:UP000002805};
RN   [1] {ECO:0000313|Proteomes:UP000002805}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25486 / DSM 40338 / CBS 914.69 / JCM 4507 / NBRC 13074 /
RC   NRRL 2958 / 5647 {ECO:0000313|Proteomes:UP000002805};
RG   The Broad Institute Genome Sequencing Platform;
RA   Fischbach M., Ward D., Young S., Jaffe D., Gnerre S., Berlin A., Heiman D.,
RA   Hepburn T., Sykes S., Alvarado L., Kodira C.D., Straight P., Clardy J.,
RA   Hung D., Kolter R., Mekalanos J., Walker S., Walsh C.T., Lander E.,
RA   Galagan J., Nusbaum C., Birren B.;
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000002805}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25486 / DSM 40338 / CBS 914.69 / JCM 4507 / NBRC 13074 /
RC   NRRL 2958 / 5647 {ECO:0000313|Proteomes:UP000002805};
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Microbial Sequencing Center;
RA   Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA   Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA   Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA   Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA   Thomson T., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA   Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA   Haas B., Nusbaum C., Birren B.;
RT   "The genome sequence of Streptomyces pristinaespiralis strain ATCC 25486.";
RL   Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Ketone degradation; acetoin degradation.
CC       {ECO:0000256|ARBA:ARBA00005101}.
CC   -!- SIMILARITY: Belongs to the histone deacetylase family.
CC       {ECO:0000256|ARBA:ARBA00005947}.
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DR   EMBL; CM000950; EDY66053.2; -; Genomic_DNA.
DR   AlphaFoldDB; B5HGU2; -.
DR   eggNOG; COG0123; Bacteria.
DR   HOGENOM; CLU_007727_8_0_11; -.
DR   UniPathway; UPA00040; -.
DR   Proteomes; UP000002805; Chromosome.
DR   GO; GO:0045150; P:acetoin catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd09994; HDAC_AcuC_like; 1.
DR   Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR   InterPro; IPR003085; AcuC.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625:SF13; HISTONE DEACETYLASE HDAC1; 1.
DR   PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PRINTS; PR01272; ACUCPROTEIN.
DR   PRINTS; PR01270; HDASUPER.
DR   SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Acetoin catabolism {ECO:0000256|ARBA:ARBA00022627};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002805}.
FT   DOMAIN          17..312
FT                   /note="Histone deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF00850"
SQ   SEQUENCE   387 AA;  41367 MW;  44F0BBC5F05E6F48 CRC64;
     MLMWDEAVTG YDFGSGHPMD PVRLALTMGL VRAYGLDRAM RVVSARPAGA STLRLVHRQD
     YVDAVRAASA DPKAADQSYG LGTVDDPAFE GMHEASALIA GQSVGAAEAV WRGEAAHAVN
     FAGGLHHAMP GGASGFCIYN DASLAIARLL ELGAERVAYV DVDVHHGDGV QAAFWDDPRV
     LTVSLHEHPQ TLFPQTGRPE ETGAAGAAEG SAVNVALPAG TGDQGWLRAF HAVVPELLAD
     FRPQVLVTQH GADTHFEDPL AHLAVSLDAQ RAVQEACHTL AHEHVEGGRW VALGGGGYAV
     VDVVPRSWTH LVGIAAHQPV EPESVIPSSW RDEVYARTRQ LAPARMTDGR WPVAWRGWEE
     GYDPADRLDQ AVLATRRAVF PLRGLLA
//