ID   B5HKI4_STRE2            Unreviewed;       793 AA.
AC   B5HKI4;
DT   14-OCT-2008, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2008, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   SubName: Full=Xanthine dehydrogenase {ECO:0000313|EMBL:EDY67345.1};
GN   ORFNames=SSDG_05672 {ECO:0000313|EMBL:EDY67345.1};
OS   Streptomyces pristinaespiralis (strain ATCC 25486 / DSM 40338 / CBS 914.69
OS   / JCM 4507 / NBRC 13074 / NRRL 2958 / 5647).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=457429 {ECO:0000313|EMBL:EDY67345.1, ECO:0000313|Proteomes:UP000002805};
RN   [1] {ECO:0000313|Proteomes:UP000002805}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25486 / DSM 40338 / CBS 914.69 / JCM 4507 / NBRC 13074 /
RC   NRRL 2958 / 5647 {ECO:0000313|Proteomes:UP000002805};
RG   The Broad Institute Genome Sequencing Platform;
RA   Fischbach M., Ward D., Young S., Jaffe D., Gnerre S., Berlin A., Heiman D.,
RA   Hepburn T., Sykes S., Alvarado L., Kodira C.D., Straight P., Clardy J.,
RA   Hung D., Kolter R., Mekalanos J., Walker S., Walsh C.T., Lander E.,
RA   Galagan J., Nusbaum C., Birren B.;
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000002805}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25486 / DSM 40338 / CBS 914.69 / JCM 4507 / NBRC 13074 /
RC   NRRL 2958 / 5647 {ECO:0000313|Proteomes:UP000002805};
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Microbial Sequencing Center;
RA   Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA   Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA   Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA   Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA   Thomson T., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA   Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA   Haas B., Nusbaum C., Birren B.;
RT   "The genome sequence of Streptomyces pristinaespiralis strain ATCC 25486.";
RL   Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CM000950; EDY67345.1; -; Genomic_DNA.
DR   AlphaFoldDB; B5HKI4; -.
DR   eggNOG; COG1529; Bacteria.
DR   HOGENOM; CLU_001681_2_3_11; -.
DR   Proteomes; UP000002805; Chromosome.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 3.90.1170.50; Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead; 1.
DR   Gene3D; 3.30.365.10; Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain; 4.
DR   InterPro; IPR000674; Ald_Oxase/Xan_DH_a/b.
DR   InterPro; IPR036856; Ald_Oxase/Xan_DH_a/b_sf.
DR   InterPro; IPR016208; Ald_Oxase/xanthine_DH-like.
DR   InterPro; IPR008274; AldOxase/xan_DH_MoCoBD1.
DR   InterPro; IPR046867; AldOxase/xan_DH_MoCoBD2.
DR   InterPro; IPR037165; AldOxase/xan_DH_Mopterin-bd_sf.
DR   InterPro; IPR017609; Xanthine_dehydrogenase_dsu.
DR   NCBIfam; TIGR03196; pucD; 1.
DR   PANTHER; PTHR11908:SF132; ALDEHYDE OXIDASE 1-RELATED; 1.
DR   PANTHER; PTHR11908; XANTHINE DEHYDROGENASE; 1.
DR   Pfam; PF01315; Ald_Xan_dh_C; 1.
DR   Pfam; PF02738; MoCoBD_1; 1.
DR   Pfam; PF20256; MoCoBD_2; 1.
DR   SMART; SM01008; Ald_Xan_dh_C; 1.
DR   SUPFAM; SSF54665; CO dehydrogenase molybdoprotein N-domain-like; 1.
DR   SUPFAM; SSF56003; Molybdenum cofactor-binding domain; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002805}.
FT   DOMAIN          34..141
FT                   /note="Aldehyde oxidase/xanthine dehydrogenase a/b
FT                   hammerhead"
FT                   /evidence="ECO:0000259|SMART:SM01008"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   793 AA;  84459 MW;  48A9E2D4E6A3C756 CRC64;
     MTMATTGTPT NLTQKTKGGI GESTLRPDGT LKVTGEFAYS SDMWHEDMLW GQILRSTVAH
     AEIVSIDTSE ALAQAGVHAV LTYDDLPTDV RNYGLEIQDT PVLAHGVVRH HGEPVALVAA
     DHPETARRAA AKIKVEYKEL PVVTDEASAT APDAPLLHPG RDDHHAGHVP HPNIVHRQPI
     VRGDADEAAK RADVIVSGEY TFGMQDQAFL GPESGLAVPA EDGGVDLYVA TQWLHSDLRQ
     IAPVLGLPED KVRMTLSGVG GAFGGREDLS MQIHACLLAL RTGKPVKIVY NRFESFFGHV
     HRHPAKLWYE HGATRDGRIT HMKCRIVLDG GAYASASPAV VGNASSLSVG PYVIDDVDIE
     AIALYTNNPP CGAMRGFGAV QACFAYEAQM DKLAKALGMD PVELRQLNAM EQGTLLPTGQ
     PVDSPAPVAE LLRRVKARPL PPERQWESTE GADVRALPGG LSNTTHGEGV VRGVGYAVGI
     KNVGFSEGFD DYSTAKVRME VIAGEPVATV HTAMAEVGQG GVTVHAQIAR TELGVSQVTI
     SPADTQVGSA GSTSASRQTY VTGGAVKNSC ELVREKVLEI GRRKFGTYHP AWATAELLLE
     SGKVVTDGGE VLADLVDVLE DEAVEIEAEW RHRPTEAFDL RTGQGNGHVQ YSFAAHRAVV
     EVDTELGLVK VIELACAQDV GKALNPLSVI GQIQGGTTQG LGIAVMEEII VDPKTAKVRN
     PSFTDYLIPT ILDTPTIPVD VLELADDNAP YGLRGIGEAP TLSSTPAVLA AIRNATGLEL
     DRTPVRPEHL TGT
//