ID B5II71_9CYAN Unreviewed; 294 AA.
AC B5II71;
DT 14-OCT-2008, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2008, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE RecName: Full=S-formylglutathione hydrolase {ECO:0000256|RuleBase:RU363068};
DE EC=3.1.2.12 {ECO:0000256|RuleBase:RU363068};
GN Name=fghA {ECO:0000313|EMBL:EDY38735.1};
GN ORFNames=CPCC7001_1614 {ECO:0000313|EMBL:EDY38735.1};
OS Cyanobium sp. PCC 7001.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales;
OC Prochlorococcaceae; Cyanobium.
OX NCBI_TaxID=180281 {ECO:0000313|EMBL:EDY38735.1, ECO:0000313|Proteomes:UP000003950};
RN [1] {ECO:0000313|EMBL:EDY38735.1, ECO:0000313|Proteomes:UP000003950}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7001 {ECO:0000313|EMBL:EDY38735.1,
RC ECO:0000313|Proteomes:UP000003950};
RA Lily E., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G.,
RA Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Serine hydrolase involved in the detoxification of
CC formaldehyde. {ECO:0000256|RuleBase:RU363068}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + S-formylglutathione = formate + glutathione + H(+);
CC Xref=Rhea:RHEA:14961, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:15740, ChEBI:CHEBI:57688, ChEBI:CHEBI:57925; EC=3.1.2.12;
CC Evidence={ECO:0000256|ARBA:ARBA00000080,
CC ECO:0000256|RuleBase:RU363068};
CC -!- SIMILARITY: Belongs to the esterase D family.
CC {ECO:0000256|ARBA:ARBA00005622, ECO:0000256|RuleBase:RU363068}.
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DR EMBL; DS990556; EDY38735.1; -; Genomic_DNA.
DR RefSeq; WP_006910640.1; NZ_DS990556.1.
DR AlphaFoldDB; B5II71; -.
DR STRING; 180281.CPCC7001_1614; -.
DR ESTHER; 9chro-b5ii71; A85-EsteraseD-FGH.
DR eggNOG; COG0627; Bacteria.
DR HOGENOM; CLU_056472_0_1_3; -.
DR OrthoDB; 9777383at2; -.
DR Proteomes; UP000003950; Unassembled WGS sequence.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0018738; F:S-formylglutathione hydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0046294; P:formaldehyde catabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000801; Esterase-like.
DR InterPro; IPR014186; S-formylglutathione_hydrol.
DR NCBIfam; TIGR02821; fghA_ester_D; 1.
DR PANTHER; PTHR10061; S-FORMYLGLUTATHIONE HYDROLASE; 1.
DR PANTHER; PTHR10061:SF1; S-FORMYLGLUTATHIONE HYDROLASE YEIG; 1.
DR Pfam; PF00756; Esterase; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU363068, ECO:0000313|EMBL:EDY38735.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000003950};
KW Serine esterase {ECO:0000256|RuleBase:RU363068}.
FT ACT_SITE 151
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR614186-1"
FT ACT_SITE 235
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR614186-1"
FT ACT_SITE 268
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR614186-1"
SQ SEQUENCE 294 AA; 31518 MW; A84F72746EC76879 CRC64;
MSPLELLSDS RCFGGSQRRY RHQSRELACS MVFGVFLPPA ALQGAQVPAV YWLSGLTCTD
ENMAQKAGAQ RLAAELGLAL VLPDTSPRGA AVPDDPDGGW DFGHGAGFYV DATEAPWSRH
YRMHSYVVEE LPRLVEAELP LTPRRSICGH SMGGHGALVA ALRHPGRYGA VSAFAPIANP
SACPWGQKAF THLLGPDPAT WQGWDAAALL RAGHRALGPD GDTPLPILVD QGTADPFLQS
QLHPEALREA AAAAGQPLEL RLQEGYDHSY YGIASFIADH LAWHARALLG PLQP
//
