ID B5LRM7_9ALPH Unreviewed; 333 AA.
AC B5LRM7;
DT 14-OCT-2008, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2008, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=UL2 {ECO:0000313|EMBL:ACH68575.1, ECO:0000313|EMBL:AFC61882.1};
DE SubName: Full=Uracil-DNA glycosylase {ECO:0000313|EMBL:AFD61623.1};
GN Name=UL2 {ECO:0000313|EMBL:AFC61882.1};
GN Synonyms=DEVCV63 {ECO:0000313|EMBL:AGA17853.1}, ORF63
GN {ECO:0000313|EMBL:AJG04930.1};
OS Anatid alphaherpesvirus 1.
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Mardivirus.
OX NCBI_TaxID=104388 {ECO:0000313|EMBL:ACH68575.1};
RN [1] {ECO:0000313|EMBL:ACH68575.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CHv {ECO:0000313|EMBL:ACH68575.1};
RA Cheng A.C., Wang M.S., Zhu D.K., Luo Q.H., Jia R.Y., Guo Y.F.;
RT "Discovery and Functional Identification of a Novel Duck enteritis virus
RT UL2 Gene.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AFD61623.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=N1 {ECO:0000313|EMBL:AFD61623.1};
RA Cheng A.C., Wang M.S., Chen X.Y., Zhu D.K., Jia R.Y., Yin X.Q., Luo Q.H.;
RT "Discovery and Functional Identification of Duck enteritis virus N1 strain
RT UL2 Gene.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AFE88884.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=LS {ECO:0000313|EMBL:AFE88886.1}, N2
RC {ECO:0000313|EMBL:AFE88884.1}, and N3 {ECO:0000313|EMBL:AFE88885.1};
RA Cheng A.C., Wang M.S., Yin X.Q., Chen X.Y., Zhu D.K., Jia R.Y.;
RT "Discovery and Functional Identification of Duck enteritis virus LS strain
RT UL2 Gene.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AFC61882.1, ECO:0000313|Proteomes:UP000135812}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHv {ECO:0000313|EMBL:AFC61882.1};
RX PubMed=22532531; DOI=10.1128/JVI.00529-12;
RA Wu Y., Cheng A., Wang M., Yang Q., Zhu D., Jia R., Chen S., Zhou Y.,
RA Wang X., Chen X.;
RT "Complete genomic sequence of chinese virulent duck enteritis virus.";
RL J. Virol. 86:5965-5965(2012).
RN [5] {ECO:0000313|EMBL:AGI78539.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=LH2011 {ECO:0000313|EMBL:AGI78539.1};
RA Wang J., Zhang C., Xu M., Hou J.;
RT "Analysis of sequences of LORF11, UL47, UL41, UL12, UL2 and US10 of a
RT virulent duck enteritis virus LH2011 isolated in China.";
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:AGA17853.1, ECO:0000313|Proteomes:UP000180937}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CV {ECO:0000313|EMBL:AGA17853.1};
RX PubMed=24287923; DOI=10.1007/s11262-013-1009-9;
RA Yang C., Li Q., Li J., Zhang G., Li H., Xia Y., Yang H., Yu K.;
RT "Comparative genomic sequence analysis between a standard challenge strain
RT and a vaccine strain of duck enteritis virus in China.";
RL Virus Genes 48:296-303(2014).
RN [7] {ECO:0000313|Proteomes:UP000098628}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Yang C., Li Q., Li J., Liu D., Li L., Li H., Xia Y., Yang H., Yu K.;
RT "Protective efficacy and genomic characteristics of a duck enteritis virus
RT attenuated by serial passage in chick embryo fibroblast.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:AJG04930.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CV p80 {ECO:0000313|EMBL:AJG04930.1};
RX PubMed=25392272; DOI=10.1007/s00705-014-2275-0;
RA Yang C., Li J., Li Q., Li L., Sun M., Li H., Xia Y., Yang H., Yu K.;
RT "Biological properties of a duck enteritis virus attenuated via serial
RT passaging in chick embryo fibroblasts.";
RL Arch. Virol. 160:267-274(2015).
RN [9] {ECO:0000313|EMBL:ATB53131.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Yulin/2016/30D {ECO:0000313|EMBL:ATB53131.1}, and
RC Yulin/2016/60D {ECO:0000313|EMBL:ATB53132.1};
RA Xie L., Xie Z.;
RT "Sequences Analysis of UL2 gene of a virulent duck enteritis virus
RT Yulin/2016/30D isolated in China.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
RN [10] {ECO:0000313|EMBL:QCA48064.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FJ47 {ECO:0000313|EMBL:QCA48064.1};
RA Liu R.C., Huang Y.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the uracil-DNA glycosylase (UDG) superfamily.
CC UNG family. {ECO:0000256|ARBA:ARBA00008184}.
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DR EMBL; EU885419; ACH68575.1; -; Genomic_DNA.
DR EMBL; JQ647509; AFC61882.1; -; Genomic_DNA.
DR EMBL; JQ043216; AFD61623.1; -; Genomic_DNA.
DR EMBL; JQ248596; AFE88884.1; -; Genomic_DNA.
DR EMBL; JQ248597; AFE88885.1; -; Genomic_DNA.
DR EMBL; JQ248598; AFE88886.1; -; Genomic_DNA.
DR EMBL; JQ673560; AGA17853.1; -; Genomic_DNA.
DR EMBL; KC480262; AGI78539.1; -; Genomic_DNA.
DR EMBL; KJ549663; AJG04930.1; -; Genomic_DNA.
DR EMBL; KX925439; ATB53131.1; -; Genomic_DNA.
DR EMBL; KX925440; ATB53132.1; -; Genomic_DNA.
DR EMBL; MH778927; QCA48064.1; -; Genomic_DNA.
DR SMR; B5LRM7; -.
DR Proteomes; UP000098628; Genome.
DR Proteomes; UP000135812; Genome.
DR Proteomes; UP000180937; Genome.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004844; F:uracil DNA N-glycosylase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006284; P:base-excision repair; IEA:UniProtKB-UniRule.
DR CDD; cd10027; UDG-F1-like; 1.
DR Gene3D; 3.40.470.10; Uracil-DNA glycosylase-like domain; 1.
DR HAMAP; MF_00148; UDG; 1.
DR InterPro; IPR002043; UDG_fam1.
DR InterPro; IPR018085; Ura-DNA_Glyclase_AS.
DR InterPro; IPR005122; Uracil-DNA_glycosylase-like.
DR InterPro; IPR036895; Uracil-DNA_glycosylase-like_sf.
DR NCBIfam; TIGR00628; ung; 1.
DR PANTHER; PTHR11264; URACIL-DNA GLYCOSYLASE; 1.
DR PANTHER; PTHR11264:SF0; URACIL-DNA GLYCOSYLASE; 1.
DR Pfam; PF03167; UDG; 1.
DR SMART; SM00986; UDG; 1.
DR SMART; SM00987; UreE_C; 1.
DR SUPFAM; SSF52141; Uracil-DNA glycosylase-like; 1.
DR PROSITE; PS00130; U_DNA_GLYCOSYLASE; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Host nucleus {ECO:0000256|ARBA:ARBA00022562};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000135812}.
FT DOMAIN 157..316
FT /note="Uracil-DNA glycosylase-like"
FT /evidence="ECO:0000259|SMART:SM00986"
FT REGION 39..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 172
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10072"
SQ SEQUENCE 333 AA; 37295 MW; D1B563AD4EFBBABF CRC64;
MTEPATETRI CIASKTLRPA SVMHSIQTRD MAEDMTKVNP DTMADDRLPS PSQAPKRRRP
CGAPAGFVAC MREGGGIAQQ PQTSNSSGRG EVAPSWFNSP TEWEKLSGDY CIGDAWREVL
YQELQSEVGS RVLLEYERRC DIEEVLPPKN EIFTWTRYCA PSDVKVIIVG QDPYHQPGQA
HGLAFSVRRG IQIPPSLRNI LSAVRRSYPE TKIVDHGCLE AWAKAGVLLL NTTLTVRKGH
PGSHVDVGWS KIVKSVLQWL HDNKEGLVFM LWGVHAQEAF KPNCRKHCVL KYSHPSPLSR
KPFILCDHFK KANEYLEGRG VEPVDWQLPC GTV
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