ID B5MCU4_HUMAN Unreviewed; 240 AA.
AC B5MCU4;
DT 14-OCT-2008, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2008, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=Lipid droplet-associated hydrolase {ECO:0000256|ARBA:ARBA00019242};
DE AltName: Full=Lipid droplet-associated serine hydrolase {ECO:0000256|ARBA:ARBA00031924};
GN Name=LDAH {ECO:0000313|Ensembl:ENSP00000384267.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000384267.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000384267.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [3] {ECO:0007829|PubMed:25944712}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
RN [4] {ECO:0000313|Ensembl:ENSP00000384267.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lipid droplet {ECO:0000256|ARBA:ARBA00004502}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. LDAH family.
CC {ECO:0000256|ARBA:ARBA00008300}.
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DR EMBL; AC012065; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC012361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; B5MCU4; -.
DR ESTHER; human-LDAH; LIDHydrolase.
DR MassIVE; B5MCU4; -.
DR MaxQB; B5MCU4; -.
DR PeptideAtlas; B5MCU4; -.
DR ProteomicsDB; 6105; -.
DR Antibodypedia; 27316; 172 antibodies from 17 providers.
DR Ensembl; ENST00000403006.6; ENSP00000384267.1; ENSG00000118961.15.
DR UCSC; uc061gzg.1; human.
DR HGNC; HGNC:26145; LDAH.
DR VEuPathDB; HostDB:ENSG00000118961; -.
DR GeneTree; ENSGT00390000009688; -.
DR ChiTaRS; LDAH; human.
DR Proteomes; UP000005640; Chromosome 2.
DR Bgee; ENSG00000118961; Expressed in adrenal tissue and 173 other cell types or tissues.
DR ExpressionAtlas; B5MCU4; baseline and differential.
DR GO; GO:0005811; C:lipid droplet; IEA:UniProtKB-SubCell.
DR GO; GO:0016298; F:lipase activity; IEA:InterPro.
DR GO; GO:0019915; P:lipid storage; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR019363; LDAH.
DR PANTHER; PTHR13390; LIPASE; 1.
DR PANTHER; PTHR13390:SF0; LIPID DROPLET-ASSOCIATED HYDROLASE; 1.
DR Pfam; PF10230; LIDHydrolase; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 1: Evidence at protein level;
KW Lipid droplet {ECO:0000256|ARBA:ARBA00022677};
KW Proteomics identification {ECO:0007829|EPD:B5MCU4,
KW ECO:0007829|MaxQB:B5MCU4};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
SQ SEQUENCE 240 AA; 28013 MW; BB7F8E99F1C5C77E CRC64;
MKLVLIGHSI GSYFTLQMLK RVPELPVIRA FLLFPTIERM SESPNGRIAT PLLCWFRYVL
YVTGYLLLKP CPETIKSLLI RRGLQVMNLE NEFSPLNILE PFCLANAAYL GGQEMMEVVK
RDDETIKEHL CKLTFYYGTI DPWCPKEYYE DIKKDFPEGD IRLCEKNIPH AFITHFNQEM
ADMIADSLKD DLSKIGNPSW HYHSLRTMRC PSAQILKPPD ERFGSDLLPT YWWKNQISRD
//
