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Database: UniProt
Entry: B5MDW0_HUMAN
LinkDB: B5MDW0_HUMAN
Original site: B5MDW0_HUMAN 
ID   B5MDW0_HUMAN            Unreviewed;       455 AA.
AC   B5MDW0;
DT   14-OCT-2008, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2008, sequence version 1.
DT   16-OCT-2019, entry version 92.
DE   SubName: Full=Erythroblast transformation-specific transcription factor ERG variant 10 {ECO:0000313|EMBL:AJT59682.1};
DE   SubName: Full=Transcriptional regulator ERG {ECO:0000313|Ensembl:ENSP00000381877};
GN   Name=ERG {ECO:0000313|EMBL:AJT59682.1,
GN   ECO:0000313|Ensembl:ENSP00000381877};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000381877, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000381877, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10830953; DOI=10.1038/35012518;
RG   Chromosome 21 mapping and sequencing consortium;
RA   Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T.,
RA   Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y.,
RA   Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K.,
RA   Polley A., Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D.,
RA   Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W.,
RA   Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S.,
RA   Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E.,
RA   Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P.,
RA   Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H.,
RA   Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E.,
RA   Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F.,
RA   Lehrach H., Reinhardt R., Yaspo M.-L.;
RT   "The DNA sequence of human chromosome 21.";
RL   Nature 405:311-319(2000).
RN   [2] {ECO:0000313|Ensembl:ENSP00000381877}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:AJT59682.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Hollenhorst P.C., Selvaraj N., Kedage V.;
RT   "Homo sapiens v-ets avian erythroblastosis virus E26 oncogene homolog
RT   (ERG), new transcript variant identified.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000213|PubMed:28112733}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=28112733;
RA   Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA   Nielsen M.L.;
RT   "Site-specific mapping of the human SUMO proteome reveals co-
RT   modification with phosphorylation.";
RL   Nat. Struct. Mol. Biol. 24:325-336(2017).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019,
CC       ECO:0000256|SAAS:SAAS00594387}.
CC   -!- SIMILARITY: Belongs to the ETS family.
CC       {ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594391}.
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DR   EMBL; AP001035; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP001036; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP001037; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP001422; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP001423; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP001426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF457287; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF510558; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KP100545; AJT59682.1; -; mRNA.
DR   RefSeq; NP_001317954.1; NM_001331025.1.
DR   SMR; B5MDW0; -.
DR   MaxQB; B5MDW0; -.
DR   PRIDE; B5MDW0; -.
DR   ProteomicsDB; 6201; -.
DR   Ensembl; ENST00000398905; ENSP00000381877; ENSG00000157554.
DR   GeneID; 2078; -.
DR   UCSC; uc062acd.1; human.
DR   CTD; 2078; -.
DR   HGNC; HGNC:3446; ERG.
DR   OpenTargets; ENSG00000157554; -.
DR   GeneTree; ENSGT00940000160662; -.
DR   HOGENOM; HOG000290658; -.
DR   OrthoDB; 1113327at2759; -.
DR   ChiTaRS; ERG; human.
DR   GenomeRNAi; 2078; -.
DR   Proteomes; UP000005640; Chromosome 21.
DR   Bgee; ENSG00000157554; Expressed in 197 organ(s), highest expression level in tendon of biceps brachii.
DR   ExpressionAtlas; B5MDW0; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   DNA-binding {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594397};
KW   Nucleus {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594400};
KW   Proteomics identification {ECO:0000213|MaxQB:B5MDW0,
KW   ECO:0000213|PeptideAtlas:B5MDW0, ECO:0000213|ProteomicsDB:B5MDW0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   DOMAIN      113    199       PNT. {ECO:0000259|PROSITE:PS51433}.
FT   DOMAIN      287    367       ETS. {ECO:0000259|PROSITE:PS50061}.
FT   REGION       34     56       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION       72     92       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      217    278       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    239    261       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   455 AA;  51261 MW;  DCC10774F9DA32F7 CRC64;
     MASTIKEALS VVSEDQSLFE CAYGTPHLAK TEMTASSSSD YGQTSKMSPR VPQQDWLSQP
     PARVTIKMEC NPSQVNGSRN SPDECSVAKG GKMVGSPDTV GMNYGSYMEE KHMPPPNMTT
     NERRVIVPAD PTLWSTDHVR QWLEWAVKEY GLPDVNILLF QNIDGKELCK MTKDDFQRLT
     PSYNADILLS HLHYLRETPL PHLTSDDVDK ALQNSPRLMH ARNTDLPYEP PRRSAWTGHG
     HPTPQSKAAQ PSPSTVPKTE DQRPQLDPYQ ILGPTSSRLA NPGSGQIQLW QFLLELLSDS
     SNSSCITWEG TNGEFKMTDP DEVARRWGER KSKPNMNYDK LSRALRYYYD KNIMTKVHGK
     RYAYKFDFHG IAQALQPHPP ESSLYKYPSD LPYMGSYHAH PQKMNFVAPH PPALPVTSSS
     FFAAPNPYWN SPTGGIYPNT RLPTSHMPSH LGTYY
//
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