ID B5QTD1_PIG Unreviewed; 223 AA.
AC B5QTD1; A0A5G2QPR1;
DT 04-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 04-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE SubName: Full=B-cell antigen receptor complex-associated protein alpha chain isoform 1 {ECO:0000313|EMBL:HDA69111.1};
DE SubName: Full=CD79-alpha protein {ECO:0000313|EMBL:CAP45900.1};
DE SubName: Full=CD79a molecule {ECO:0000313|Ensembl:ENSSSCP00000066885.2};
GN Name=CD79A {ECO:0000313|Ensembl:ENSSSCP00000066885.2,
GN ECO:0000313|VGNC:VGNC:86429};
GN Synonyms=CD79-alpha {ECO:0000313|EMBL:CAP45900.1};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|EMBL:CAP45900.1};
RN [1] {ECO:0000313|EMBL:CAP45900.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Splenocyte {ECO:0000313|EMBL:CAP45900.1};
RA Lee S.;
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAP45900.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Splenocyte {ECO:0000313|EMBL:CAP45900.1};
RX PubMed=18584878; DOI=10.1016/j.vetimm.2008.05.014;
RA Lee S.J., Kim S.J., Park C.G., Park J., Kim J.H., Chun T.;
RT "Molecular cloning and expression analysis of pig CD79alpha.";
RL Vet. Immunol. Immunopathol. 125:368-374(2008).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000066885.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000066885.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:HDA69111.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [5] {ECO:0000313|Ensembl:ENSSSCP00000066885.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AM915272; CAP45900.1; -; mRNA.
DR EMBL; DQIR01113635; HDA69111.1; -; Transcribed_RNA.
DR RefSeq; NP_001129434.1; NM_001135962.1.
DR PaxDb; 9823-ENSSSCP00000003295; -.
DR Ensembl; ENSSSCT00000076652.2; ENSSSCP00000066885.2; ENSSSCG00000033684.3.
DR GeneID; 100190992; -.
DR KEGG; ssc:100190992; -.
DR CTD; 973; -.
DR VGNC; VGNC:86429; CD79A.
DR eggNOG; ENOG502S1DI; Eukaryota.
DR GeneTree; ENSGT00940000154363; -.
DR HOGENOM; CLU_106774_0_0_1; -.
DR OMA; RWQNEKF; -.
DR OrthoDB; 5361630at2759; -.
DR TreeFam; TF336032; -.
DR Proteomes; UP000008227; Chromosome 6.
DR Bgee; ENSSSCG00000033684; Expressed in blood and 41 other cell types or tissues.
DR GO; GO:0019815; C:B cell receptor complex; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0050853; P:B cell receptor signaling pathway; IEA:InterPro.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR039695; CD79a/CD79b.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR003110; Phos_immunorcpt_sig_ITAM.
DR PANTHER; PTHR14334; B-CELL ANTIGEN RECEPTOR COMPLEX-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR14334:SF1; B-CELL ANTIGEN RECEPTOR COMPLEX-ASSOCIATED PROTEIN ALPHA CHAIN; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF02189; ITAM; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00077; ITAM; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51055; ITAM_1; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:HDA69111.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..223
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014567744"
FT TRANSMEM 141..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 11..107
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 223 AA; 24795 MW; 7BB3367842D1BE8D CRC64;
MPGGRRALQT PPATIFLLLI SAAALGPCCQ ALWVDWGPPS VTVSVGDKVS LPCRHNSNST
NITWWRVPQG NSTWPPVMDL SELGPKGELI IQQVNKSHRG MYRCEVNEGQ RIQRSCGTYL
RVRDPLPRPF LDMGEGTKNN IITAEGIILL ICAVVPGTLL LFRKRWQNVK FGADVQDDYD
DENLYEGLNL DDCSMYEDIS RGLQGTYQDV GSLHIGDVQL EKP
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