ID B5X1H6_SALSA Unreviewed; 433 AA.
AC B5X1H6;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=N-acylneuraminate cytidylyltransferase {ECO:0000256|ARBA:ARBA00012491};
DE EC=2.7.7.43 {ECO:0000256|ARBA:ARBA00012491};
GN Name=NEUA {ECO:0000313|EMBL:ACI33157.1};
GN Synonyms=neua {ECO:0000313|RefSeq:NP_001133396.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|EMBL:ACI33157.1};
RN [1] {ECO:0000313|EMBL:ACI33157.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACI33157.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RA Leong J., von Schalburg K., Cooper G., Moore R., Holt R., Davidson W.S.,
RA Koop B.F.;
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACI33157.1, ECO:0000313|RefSeq:NP_001133396.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACI33157.1};
RX PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA Koop B.F.;
RT "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT evolutionary pressures on a post-tetraploidization genome.";
RL BMC Genomics 11:279-279(2010).
RN [3] {ECO:0000313|EMBL:ACI33157.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACI33157.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:NP_001133396.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an N-acylneuraminate + CTP = a CMP-N-acyl-beta-neuraminate +
CC diphosphate; Xref=Rhea:RHEA:11344, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:37563, ChEBI:CHEBI:60073, ChEBI:CHEBI:68671; EC=2.7.7.43;
CC Evidence={ECO:0000256|ARBA:ARBA00001862};
CC -!- PATHWAY: Amino-sugar metabolism; N-acetylneuraminate metabolism.
CC {ECO:0000256|ARBA:ARBA00005141}.
CC -!- SIMILARITY: Belongs to the CMP-NeuNAc synthase family.
CC {ECO:0000256|ARBA:ARBA00010726}.
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DR EMBL; BT044895; ACI33157.1; -; mRNA.
DR RefSeq; NP_001133396.1; NM_001139924.1.
DR STRING; 8030.ENSSSAP00000051954; -.
DR PaxDb; 8030-ENSSSAP00000051954; -.
DR GeneID; 100194895; -.
DR KEGG; sasa:100194895; -.
DR CTD; 100194895; -.
DR OrthoDB; 5486419at2759; -.
DR UniPathway; UPA00628; -.
DR Proteomes; UP000087266; Chromosome ssa17.
DR GO; GO:0005634; C:nucleus; ISS:AgBase.
DR GO; GO:0008781; F:N-acylneuraminate cytidylyltransferase activity; ISS:AgBase.
DR GO; GO:0006054; P:N-acetylneuraminate metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd02513; CMP-NeuAc_Synthase; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR003329; Cytidylyl_trans.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR21485; HAD SUPERFAMILY MEMBERS CMAS AND KDSC; 1.
DR PANTHER; PTHR21485:SF3; N-ACYLNEURAMINATE CYTIDYLYLTRANSFERASE; 1.
DR Pfam; PF02348; CTP_transf_3; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 2: Evidence at transcript level;
KW Nucleotidyltransferase {ECO:0000313|EMBL:ACI33157.1,
KW ECO:0000313|RefSeq:NP_001133396.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transferase {ECO:0000313|EMBL:ACI33157.1}.
SQ SEQUENCE 433 AA; 48264 MW; A995452A9226B94E CRC64;
MAAAKKRTRS GIEDVRDRKA KVIKDSGEKR HIAALILARG GSKGIPLKNI KMLAGVPLIG
WVLRAAVDSK QFDSVWVSTD HDDIEKVAKA WGAQVHRRSP EVSKDSSSSL DTIQEFVRLN
PEVDVICHIQ ATSPCLHPFH LKEALEVITK QGFTSVFSVV RQHHFRWQEV KKGGSVATQP
LNLDPSNRPR RQDWDGELCE NGSFYFSTRA LIEEGVLQGG KWAYYEMLPE YSVDIDVDID
WPVAEQRVLR FGYFGLDKPE VVRLLLCKVS GCLTDGRVLI SVSGEEMVSV NTRDTMGIRM
LQREGVEVIL ISSSEDPVTK ALADKLSQRT GCEVRQLGKD IQGEVKAMMD DKDLDWKEVA
YMGNDAPDVD CLNLAGLSAV PRDAPVVAIN AAKYSCHSAA GRGAVREFSE HILLLKKKAK
SQMEQDRIHR NTF
//
