ID B5X2U8_SALSA Unreviewed; 672 AA.
AC B5X2U8;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Thrombopoietin receptor {ECO:0000313|EMBL:ACI33629.1, ECO:0000313|RefSeq:XP_013978958.1};
GN Name=TPOR {ECO:0000313|EMBL:ACI33629.1};
GN Synonyms=LOC106560515 {ECO:0000313|RefSeq:XP_013978958.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|EMBL:ACI33629.1};
RN [1] {ECO:0000313|EMBL:ACI33629.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACI33629.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RA Leong J., von Schalburg K., Cooper G., Moore R., Holt R., Davidson W.S.,
RA Koop B.F.;
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACI33629.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACI33629.1};
RX PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA Koop B.F.;
RT "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT evolutionary pressures on a post-tetraploidization genome.";
RL BMC Genomics 11:279-279(2010).
RN [3] {ECO:0000313|EMBL:ACI33629.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACI33629.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:XP_013978958.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013978958.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BT045367; ACI33629.1; -; mRNA.
DR RefSeq; XP_013978958.1; XM_014123483.1.
DR GeneID; 106560515; -.
DR OrthoDB; 5297263at2759; -.
DR Proteomes; UP000087266; Chromosome ssa10.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR015152; Growth/epo_recpt_lig-bind.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR23037; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23037:SF42; CYTOKINE RECEPTOR COMMON SUBUNIT GAMMA ISOFORM X1-RELATED; 1.
DR Pfam; PF09067; EpoR_lig-bind; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR PROSITE; PS50853; FN3; 2.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:ACI33629.1, ECO:0000313|RefSeq:XP_013978958.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..477
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 161..261
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 358..453
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 537..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 672 AA; 75670 MW; 1AB391C4A7D52F7D CRC64;
MGHTCHLSVD VMDLHLTSRV LSVWLWIIAG WVNVLGHGIV DEAVPHLSKK DVLLLAGDAD
PKCFTRTQYD FTCFWEAPGN TAYDFFYRND NEEKEKRCKL TLQRTEKGEE EEEEKVLHVC
FFPCSDVFLF TLTHIRVVES SSNYTLFTRT ISVEDQGLLE PPVNVSLHPT GQAGQLQVAW
HASRDWKNNV HYGMRYSSQG LGERTELIRS MRSPIHSLVS LLPGEVVSVQ LRVKPNGYSE
TETSGHWSDW SVPITAMVPQ SAADISLLCH TSDLQNITCQ WNGQSYRDAT YTLNYKLGAS
KREGWRKCLQ NENTSYQCRF HGAESSEILV KLGTGPGSLK RTFYTEPFRL NNSIQTGPPG
RLRGQWEGGR LRLRWGTPLL ALSLHLMYQL RYQPQGEAVW KLVTLQVPEN STCLDIQTGS
QYFIQVRARP NASVYAGYWS DWSPPLTVDT PSDIGALFIL CIPLMMLILS VVFLSMFSRY
LSKLKRYLWP PVPKLDKVLH GFLTDINGQT WDPPFIIKQY SEETPACVVE IMSEREAPDG
GKLPRDSSLL LSPERGSAGG EEERLPTLAL ELSQDYVTLA TDDVIPCFRG NKYVYDGEVG
TESRSLGEDE VLQMRCHCSS NFPSSSSTTD ILNRSYMLLA EQPIEILDCQ GSSRAGKLYA
KLEGTNSANA NT
//
